Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Magi2provided by MGI
Official Full Name: membrane associated guanylate kinase, WW and PDZ domain containing 2provided by MGI
Primary source: MGI:MGI:1354953
See related: Ensembl:ENSMUSG00000040003 AllianceGenome:MGI:1354953
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AIP-1; Acvri1; Magi-2; S-SCAM; Acvrip1; Acvrinp1; mKIAA0705
Summary: Enables SMAD binding activity and type II activin receptor binding activity. Involved in several processes, including SMAD protein signal transduction; neuroligin clustering involved in postsynaptic membrane assembly; and positive regulation of synaptic vesicle clustering. Acts upstream of or within signal transduction. Located in several cellular components, including centriole; ciliary base; and photoreceptor inner segment. Is expressed in several structures, including branchial arch; genitourinary system; limb; nervous system; and vibrissa. Used to study schizophrenia. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 7.1), frontal lobe adult (RPKM 6.2) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 8.6 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (19431787..20909790)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (19219387..20704792)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease through communication with TGF-beta-Smad3/nephrin pathway.
Title: MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease through communication with TGF-β-Smad3/nephrin pathway.
S-SCAM inhibits Axin-dependent synaptic function of GSK3beta in a sex-dependent manner.
Title: S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner.
In summary,MAGI-2 and Fyn protect dendrin fromNedd4-2-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI-2 in podocytes results in FSGS.
Title: Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes.
Magi2 is an essential component of the slit diaphragm complex that is required for nephrin localization and foot process formation.
Title: Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.
MAGI-2 has a critical role in maintaining the functional structure of the slit diaphragm and this molecule has an essential role in the functioning of the kidney filtration barrier.
Title: MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney.
We showed the expression patterns of MAGI-2 in detail in adult mice. Significant Venus expression was detected in various regions of the brain, also detected in glomeruli of the kidney. We found the novel expression of MAGI-2 in the testis.
Title: Generation of Venus reporter knock-in mice revealed MAGI-2 expression patterns in adult mice.
MAGI-2 is required for the integrity of the kidney filter and podocyte survival.
Title: MAGI-2 scaffold protein is critical for kidney barrier function.
elevation of S-SCAM expression in the excitatory neurons of forebrain was sufficient to induce an schizophrenia-like phenotype in mice.
Title: S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model.
In Usher syndrome 1G, mutations in SANS eliminate Magi2 binding and thereby deregulate endocytosis, lead to defective ciliary transport modules and ultimately disrupt photoreceptor cell function inducing retinal degeneration.
Title: Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis.
ARIP1 and ARIP2 are co-expressed in some nerve cells and their biological activities are distinct.
Title: Co-expression of activin receptor-interacting protein 1 and 2 in mouse nerve cells.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU022528 (e-PCR)
- UniSTS:167445

AU022721 (e-PCR)
- UniSTS:167447

AA850692 (e-PCR)
- UniSTS:250426

D5Mit250 (e-PCR), detects polymorphism
- UniSTS:130385

NoName (e-PCR)
- UniSTS:235134

D5Mit295 (e-PCR), detects polymorphism
- UniSTS:130433

AU023683 (e-PCR)
- UniSTS:179141

NoName (e-PCR)
- UniSTS:225240

RH115309 (e-PCR)
- UniSTS:142555

D5Mit147 (e-PCR), detects polymorphism
- UniSTS:130273

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables activin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-1 adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables beta-1 adrenergic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor complex adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor complex adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor complex adaptor activity	NAS Non-traceable Author Statement more info	PubMed
enables structural constituent of postsynaptic density	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynaptic specialization	ISO Inferred from Sequence Orthology more info
enables type II activin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type II activin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuroligin clustering involved in postsynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in podocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic vesicle clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in ciliary base	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extrinsic component of postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in slit diaphragm	ISO Inferred from Sequence Orthology more info
located_in slit diaphragm	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Names: activin receptor interacting protein 1; atrophin-1-interacting protein 1; membrane-associated guanylate kinase inverted 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170745.1 → NP_001164216.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 3

See identical proteins and their annotated locations for NP_001164216.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK147530, BG297092

Consensus CDS

CCDS51425.1

UniProtKB/TrEMBL

Q80TU0

Related

ENSMUSP00000099094.4, ENSMUST00000101558.10

Conserved Domains (6) summary

smart00228
Location:597 → 683

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:961 → 1041

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:140 → 169

WW; WW domain

pfam16663
Location:34 → 95

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:518 → 592

MAGI_u5; Unstructured region on MAGI

cl17190
Location:1 → 127

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
NM_001170746.1 → NP_001164217.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_001164217.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC113596, AC121774, AC125138, AC132570, AC157608, AC158141, AC161494, AC161802

Consensus CDS

CCDS51424.1

UniProtKB/Swiss-Prot

Q3UH81, Q6GT88, Q8BYT1, Q8CA85, Q9WVQ1

UniProtKB/TrEMBL

Q80TU0

Related

ENSMUSP00000085872.4, ENSMUST00000088516.10

Conserved Domains (6) summary

smart00072
Location:118 → 290

GuKc; Guanylate kinase homologues

smart00228
Location:774 → 860

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:304 → 334

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:1138 → 1218

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:349 → 378

WW; WW domain

pfam16666
Location:681 → 755

MAGI_u5; Unstructured region on MAGI
NM_015823.3 → NP_056638.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_056638.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC157608, AK147530, BC059005

Consensus CDS

CCDS39019.1

UniProtKB/TrEMBL

Q80TU0

Related

ENSMUSP00000110922.3, ENSMUST00000115267.7

Conserved Domains (6) summary

smart00228
Location:611 → 697

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:975 → 1055

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:140 → 169

WW; WW domain

pfam16663
Location:34 → 95

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:518 → 592

MAGI_u5; Unstructured region on MAGI

cl17190
Location:1 → 127

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

19431787..20909790

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535751.5 → XP_006535814.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7

See identical proteins and their annotated locations for XP_006535814.1

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (5) summary

smart00228
Location:774 → 860

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1138 → 1218

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:303 → 332

WW; WW domain

pfam16666
Location:681 → 755

MAGI_u5; Unstructured region on MAGI

cl17190
Location:118 → 290

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006535747.5 → XP_006535810.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X4

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (5) summary

smart00228
Location:774 → 860

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1138 → 1218

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:303 → 332

WW; WW domain

pfam16666
Location:681 → 755

MAGI_u5; Unstructured region on MAGI

cl17190
Location:118 → 290

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006535743.5 → XP_006535806.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JE00, Q80TU0

Related

ENSMUSP00000142576.2, ENSMUST00000197354.5

Conserved Domains (7) summary

smart00228
Location:774 → 860

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:1255 → 1407

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:1138 → 1218

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:303 → 332

WW; WW domain

pfam16663
Location:1245 → 1285

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:681 → 755

MAGI_u5; Unstructured region on MAGI

cl17190
Location:118 → 290

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006535748.5 → XP_006535811.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X5

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (5) summary

smart00072
Location:118 → 290

GuKc; Guanylate kinase homologues

smart00228
Location:760 → 846

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:1124 → 1204

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:303 → 332

WW; WW domain

pfam16666
Location:681 → 755

MAGI_u5; Unstructured region on MAGI
XM_006535745.5 → XP_006535808.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

A0A0G2JEG6, Q80TU0

Related

ENSMUSP00000142764.2, ENSMUST00000197443.5

Conserved Domains (7) summary

smart00228
Location:760 → 846

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:1241 → 1393

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:1124 → 1204

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:303 → 332

WW; WW domain

pfam16663
Location:1231 → 1271

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:681 → 755

MAGI_u5; Unstructured region on MAGI

cl17190
Location:118 → 290

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006535744.5 → XP_006535807.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (6) summary

smart00228
Location:772 → 858

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:1253 → 1405

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:1136 → 1216

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:303 → 332

WW; WW domain

pfam16663
Location:1243 → 1283

MAGI_u1; Unstructured region on MAGI

cl17190
Location:118 → 290

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_036165261.1 → XP_036021154.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (8) summary

smart00456
Location:186 → 217

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:611 → 697

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:1092 → 1244

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:975 → 1055

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:140 → 169

WW; WW domain

pfam16663
Location:34 → 95

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:523 → 594

MAGI_u5; Unstructured region on MAGI

cl17190
Location:1 → 127

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_006535750.5 → XP_006535813.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6

See identical proteins and their annotated locations for XP_006535813.1

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (8) summary

smart00456
Location:186 → 217

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:611 → 697

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:1092 → 1244

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:975 → 1055

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:140 → 169

WW; WW domain

pfam16663
Location:34 → 95

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:523 → 594

MAGI_u5; Unstructured region on MAGI

cl17190
Location:1 → 127

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_036165262.1 → XP_036021155.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X9

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (7) summary

smart00456
Location:127 → 158

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:552 → 638

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:1033 → 1185

PHA03307; transcriptional regulator ICP4; Provisional

COG5104
Location:53 → 126

PRP40; Splicing factor [RNA processing and modification]

cd00992
Location:916 → 996

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:81 → 110

WW; WW domain

pfam16666
Location:464 → 535

MAGI_u5; Unstructured region on MAGI
XM_006535749.5 → XP_006535812.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6

See identical proteins and their annotated locations for XP_006535812.1

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (8) summary

smart00456
Location:186 → 217

WW; Domain with 2 conserved Trp (W) residues

smart00228
Location:611 → 697

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:1092 → 1244

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:975 → 1055

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:140 → 169

WW; WW domain

pfam16663
Location:34 → 95

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:523 → 594

MAGI_u5; Unstructured region on MAGI

cl17190
Location:1 → 127

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_017320968.3 → XP_017176457.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X8

UniProtKB/TrEMBL

Q80TU0

Conserved Domains (7) summary

smart00228
Location:597 → 683

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:1078 → 1230

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:961 → 1041

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:140 → 169

WW; WW domain

pfam16663
Location:34 → 95

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:518 → 592

MAGI_u5; Unstructured region on MAGI

cl17190
Location:1 → 127

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_030254656.2 → XP_030110516.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X11

UniProtKB/TrEMBL

A0A140LHL1

Conserved Domains (4) summary

smart00228
Location:382 → 468

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:863 → 1015

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:746 → 826

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16663
Location:853 → 893

MAGI_u1; Unstructured region on MAGI
XM_006535752.5 → XP_006535815.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X10

UniProtKB/TrEMBL

A0A140LHL1

Related

ENSMUSP00000146769.2, ENSMUST00000197553.5

Conserved Domains (5) summary

smart00228
Location:384 → 470

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:865 → 1017

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:748 → 828

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16663
Location:855 → 895

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:291 → 365

MAGI_u5; Unstructured region on MAGI
XM_030254657.2 → XP_030110517.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X12

UniProtKB/TrEMBL

A0A140LHL1

Conserved Domains (5) summary

smart00228
Location:370 → 456

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

PHA03307
Location:851 → 1003

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:734 → 814

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16663
Location:841 → 881

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:291 → 365

MAGI_u5; Unstructured region on MAGI