Slc20a1 solute carrier family 20, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc20a1provided by MGI
Official Full Name: solute carrier family 20, member 1provided by MGI
Primary source: MGI:MGI:108392
See related: Ensembl:ENSMUSG00000027397 AllianceGenome:MGI:108392
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glvr1; Glvr-1
Summary: Predicted to enable high-affinity phosphate:sodium symporter activity. Acts upstream of or within biomineral tissue development. Located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; submandibular gland primordium; and yolk sac. Orthologous to human SLC20A1 (solute carrier family 20 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in colon adult (RPKM 22.0), frontal lobe adult (RPKM 18.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 62.79 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (129038662..129053535)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (129198773..129211615)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sodium-dependent phosphate transporter PiT1/SLC20A1 as the receptor for the endogenous retroviral envelope syncytin-B involved in mouse placenta formation.
Title: Sodium-dependent phosphate transporter PiT1/SLC20A1 as the receptor for the endogenous retroviral envelope syncytin-B involved in mouse placenta formation.
Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.
Title: Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofiber function and survival.
Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing.
Title: Novel function of PiT1/SLC20A1 in LPS-related inflammation and wound healing.
data thus reveal a novel, Pi-transport independent function of PiT1, as a critical modulator of ER homeostasis and chondrocyte survival during endochondral ossification.
Title: PiT1/Slc20a1 Is Required for Endoplasmic Reticulum Homeostasis, Chondrocyte Survival, and Skeletal Development.
These data support the involvement of phosphate transporter 1, hereafter referred to as Pi T-1, in the initiation of skeletal mineralization and provide compelling evidence that PHOSPHO1 function is involved in MV biogenesis
Title: Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice.
propose the novel idea that PiT-1 is central to the regulation of endocytosis and autophagy in the yolk sac visceral endoderm
Title: Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm.
Pi uptake-dependent and -independent functions of PiT-1 are important for vascular smooth muscle cell processes mediating vascular calcification.
Title: Phosphate uptake-independent signaling functions of the type III sodium-dependent phosphate transporter, PiT-1, in vascular smooth muscle cells.
Mechanistically, PiT-1 and PiT-2 seem to serve redundant roles in phosphate-induced calcification of vascular smooth muscle cells.
Title: Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.
Data indicate that mice lacking SLC20A1 (PiT1) develop a profound underproduction anemia characterized by mild macrocytosis, dyserythropoiesis, increased apoptosis, and a near complete block in terminal erythroid differentiation.
Title: Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development.
Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a1.
Title: Incisor enamel formation is impaired in transgenic rats overexpressing the type III NaPi transporter Slc20a1.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M73696 (e-PCR)
- UniSTS:124977

Slc10a1 (e-PCR), detects polymorphism
- UniSTS:528184

Slc10a1 (e-PCR), detects polymorphism
- UniSTS:528185

AI607883 (e-PCR)
- UniSTS:185496

Slc20a1 (e-PCR), detects polymorphism
- UniSTS:547018

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables high-affinity phosphate:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables high-affinity phosphate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:phosphate symporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biomineral tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-dependent phosphate transporter 1

Names: gibbon ape leukemia virus receptor 1; leukemia virus receptor 1 homolog; phosphate transporter 1; piT-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159593.2 → NP_001153065.1 sodium-dependent phosphate transporter 1 isoform 2

See identical proteins and their annotated locations for NP_001153065.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL772347

UniProtKB/Swiss-Prot

Q61609

Related

ENSMUST00000141285.2

Conserved Domains (2) summary

COG0306
Location:25 → 214

PitA; Phosphate/sulfate permease [Inorganic ion transport and metabolism]

pfam01384
Location:46 → 148

PHO4; Phosphate transporter family
NM_001355252.1 → NP_001342181.1 sodium-dependent phosphate transporter 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL772347

Conserved Domains (1) summary

pfam01384
Location:247 → 392

PHO4; Phosphate transporter family
NM_015747.3 → NP_056562.1 sodium-dependent phosphate transporter 1 isoform 1

See identical proteins and their annotated locations for NP_056562.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL772347

Consensus CDS

CCDS16722.1

UniProtKB/Swiss-Prot

A2AKR9, Q3U244, Q61609, Q8CBJ1, Q91YQ9, Q9QVW6

Related

ENSMUSP00000028880.4, ENSMUST00000028880.10

Conserved Domains (1) summary

pfam01384
Location:509 → 667

PHO4; Phosphate transporter family

RNA

NR_185225.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL772347
NR_185226.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL772347

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

129038662..129053535

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159901.1 → XP_036015794.1 sodium-dependent phosphate transporter 1 isoform X1

UniProtKB/Swiss-Prot

A2AKR9, Q3U244, Q61609, Q8CBJ1, Q91YQ9, Q9QVW6

Conserved Domains (1) summary

pfam01384
Location:509 → 667

PHO4; Phosphate transporter family