Mipep mitochondrial intermediate peptidase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mipepprovided by MGI
Official Full Name: mitochondrial intermediate peptidaseprovided by MGI
Primary source: MGI:MGI:1917728
See related: Ensembl:ENSMUSG00000021993 AllianceGenome:MGI:1917728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MIP; 5730405E07Rik
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in heart and tibialis anterior. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 31. Orthologous to human MIPEP (mitochondrial intermediate peptidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 35.6), adrenal adult (RPKM 9.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 31.95 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (61022011..61142930)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (60784562..60905481)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MIPEP may contribute to the maintenance of mitochondrial quality during caloric restriction (CR) via activation of SIRT3. This novel mechanism of SIRT3 activation through MIPEP facilitates the elucidation of additional molecular pathways of CR.
Title: Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing involved in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial intermediate peptidase

NP_081712.2

EC 3.4.24.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027436.3 → NP_081712.2 mitochondrial intermediate peptidase precursor

See identical proteins and their annotated locations for NP_081712.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the functional protein.

Source sequence(s)

AI606287, AK017491, BE995975, CA460475

Consensus CDS

CCDS49517.1

UniProtKB/Swiss-Prot

A6H611, Q2YD79, Q3UJJ3, Q80VA3

Related

ENSMUSP00000069840.8, ENSMUST00000063562.9

Conserved Domains (2) summary

cd06457
Location:62 → 695

M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)

COG0339
Location:71 → 691

Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

RNA

NR_040642.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an additional exon in the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC122477, AC151835

Related

ENSMUST00000225506.2