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    Nod2 nucleotide-binding oligomerization domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 257632, updated on 14-Jan-2025

    Summary

    Official Symbol
    Nod2provided by MGI
    Official Full Name
    nucleotide-binding oligomerization domain containing 2provided by MGI
    Primary source
    MGI:MGI:2429397
    See related
    Ensembl:ENSMUSG00000055994 AllianceGenome:MGI:2429397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik
    Summary
    Enables muramyl dipeptide binding activity and pattern recognition receptor activity. Involved in several processes, including host-mediated regulation of intestinal microbiota composition; positive regulation of metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of MAPK cascade; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Predicted to be extrinsic component of plasma membrane. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); familial Mediterranean fever; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in lung adult (RPKM 1.5), spleen adult (RPKM 1.3) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nod2 in Genome Data Viewer
    Location:
    8 C3; 8 43.51 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (89373943..89415103)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88647315..88688474)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene naked cuticle 1 Neighboring gene STARR-positive B cell enhancer ABC_E10516 Neighboring gene STARR-seq mESC enhancer starr_22236 Neighboring gene STARR-seq mESC enhancer starr_22237 Neighboring gene STARR-positive B cell enhancer ABC_E2869 Neighboring gene sorting nexin 20 Neighboring gene STARR-positive B cell enhancer ABC_E3791 Neighboring gene STARR-positive B cell enhancer ABC_E6672 Neighboring gene STARR-positive B cell enhancer ABC_E108 Neighboring gene CYLD lysine 63 deubiquitinase Neighboring gene ribosomal protein S7 pseudogene Neighboring gene nucleophosmin 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (12)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables ADP binding  
    enables ATP binding  
    enables CARD domain binding  
    enables CARD domain binding  
    enables Hsp70 protein binding  
    enables Hsp70 protein binding  
    enables Hsp90 protein binding  
    enables Hsp90 protein binding  
    enables actin binding  
    enables actin binding  
    enables enzyme binding  
    enables enzyme binding  
    enables muramyl dipeptide binding PubMed 
    enables muramyl dipeptide binding PubMed 
    enables muramyl dipeptide binding  
    enables muramyl dipeptide binding  
    enables pattern recognition receptor activity PubMed 
    enables pattern recognition receptor activity PubMed 
    enables pattern recognition receptor activity  
    enables pattern recognition receptor activity  
    enables peptidoglycan binding  
    enables peptidoglycan binding  
    enables peptidoglycan binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables ubiquitin binding  
    enables ubiquitin binding  
    Items 1 - 25 of 30
    Items 1 - 25 of 170
    Process Evidence Code Pubs
    acts_upstream_of ERK1 and ERK2 cascade PubMed 
    acts_upstream_of JNK cascade PubMed 
    acts_upstream_of MAPK cascade PubMed 
    acts_upstream_of_or_within activation of immune response PubMed 
    involved_in adaptive immune response  
    involved_in antibacterial innate immune response  
    involved_in antibacterial innate immune response  
    acts_upstream_of biosynthetic process of antibacterial peptides active against Gram-positive bacteria PubMed 
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to muramyl dipeptide  
    involved_in cellular response to muramyl dipeptide  
    involved_in cellular response to organic cyclic compound  
    acts_upstream_of_or_within cellular response to peptidoglycan PubMed 
    involved_in defense response PubMed 
    acts_upstream_of_or_within defense response to Gram-positive bacterium PubMed 
    acts_upstream_of_or_within defense response to Gram-positive bacterium PubMed 
    involved_in defense response to bacterium  
    involved_in defense response to bacterium PubMed 
    involved_in defense response to bacterium  
    involved_in defense response to bacterium  
    involved_in detection of bacterium  
    involved_in detection of bacterium  
    involved_in detection of biotic stimulus PubMed 
    acts_upstream_of_or_within detection of muramyl dipeptide  
    involved_in detection of muramyl dipeptide  
    involved_in detection of muramyl dipeptide  
    acts_upstream_of establishment of localization in cell PubMed 
    involved_in host-mediated regulation of intestinal microbiota composition PubMed 
    acts_upstream_of_or_within immunoglobulin production involved in immunoglobulin-mediated immune response PubMed 
    involved_in inflammatory response PubMed 
    involved_in innate immune response  
    involved_in innate immune response  
    acts_upstream_of_or_within innate immune response in mucosa PubMed 
    acts_upstream_of interleukin-12 production PubMed 
    acts_upstream_of interleukin-12 production PubMed 
    acts_upstream_of interleukin-18 production PubMed 
    acts_upstream_of interleukin-2 production PubMed 
    acts_upstream_of interleukin-6 production PubMed 
    acts_upstream_of interleukin-6 production PubMed 
    acts_upstream_of interleukin-6 production PubMed 
    involved_in intestinal stem cell homeostasis PubMed 
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    acts_upstream_of macrophage cytokine production PubMed 
    acts_upstream_of macrophage cytokine production PubMed 
    acts_upstream_of macrophage cytokine production PubMed 
    acts_upstream_of_or_within macrophage inflammatory protein-1 alpha production PubMed 
    involved_in maintenance of gastrointestinal epithelium  
    involved_in maintenance of gastrointestinal epithelium  
    acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity PubMed 
    acts_upstream_of_or_within negative regulation of T cell mediated immunity PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-12 production PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-12 production PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-18 production PubMed 
    acts_upstream_of_or_within negative regulation of interleukin-2 production PubMed 
    involved_in negative regulation of macrophage apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of macrophage cytokine production PubMed 
    acts_upstream_of_or_within negative regulation of macrophage cytokine production PubMed 
    acts_upstream_of_or_within negative regulation of toll-like receptor 2 signaling pathway PubMed 
    acts_upstream_of_or_within negative regulation of tumor necrosis factor production PubMed 
    acts_upstream_of_or_within negative regulation of type II interferon production PubMed 
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway PubMed 
    acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway PubMed 
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway PubMed 
    acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway  
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway  
    involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway  
    involved_in pattern recognition receptor signaling pathway  
    acts_upstream_of peptidyl-tyrosine phosphorylation PubMed 
    acts_upstream_of phagocytosis PubMed 
    involved_in positive regulation of B cell activation  
    involved_in positive regulation of B cell activation  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade PubMed 
    acts_upstream_of_or_within positive regulation of JNK cascade PubMed 
    acts_upstream_of_or_within positive regulation of JNK cascade PubMed 
    involved_in positive regulation of MAPK cascade PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade PubMed 
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity PubMed 
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of Notch signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of antibacterial peptide biosynthetic process PubMed 
    involved_in positive regulation of autophagy PubMed 
    acts_upstream_of_or_within positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cytokine production involved in immune response  
    involved_in positive regulation of cytokine production involved in immune response  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of dendritic cell antigen processing and presentation PubMed 
    involved_in positive regulation of dendritic cell cytokine production  
    involved_in positive regulation of dendritic cell cytokine production  
    involved_in positive regulation of epithelial cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin PubMed 
    involved_in positive regulation of innate immune response PubMed 
    acts_upstream_of_or_within positive regulation of innate immune response PubMed 
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-1 beta production  
    acts_upstream_of positive regulation of interleukin-10 production PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-12 production PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-12 production PubMed 
    involved_in positive regulation of interleukin-17 production  
    involved_in positive regulation of interleukin-17 production  
    acts_upstream_of_or_within positive regulation of interleukin-6 production PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of interleukin-8 production  
    acts_upstream_of_or_within positive regulation of macrophage cytokine production PubMed 
    acts_upstream_of_or_within positive regulation of macrophage cytokine production PubMed 
    acts_upstream_of_or_within positive regulation of macrophage cytokine production PubMed 
    involved_in positive regulation of mitophagy PubMed 
    involved_in positive regulation of monocyte chemotactic protein-1 production PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation PubMed 
    acts_upstream_of_or_within positive regulation of phagocytosis PubMed 
    involved_in positive regulation of protein K63-linked ubiquitination  
    involved_in positive regulation of protein K63-linked ubiquitination  
    involved_in positive regulation of protein ubiquitination PubMed 
    acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade PubMed 
    acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production PubMed 
    acts_upstream_of_or_within positive regulation of tumor necrosis factor production PubMed 
    involved_in positive regulation of tumor necrosis factor production  
    involved_in positive regulation of type 2 immune response  
    involved_in positive regulation of type 2 immune response  
    acts_upstream_of_or_within positive regulation of xenophagy PubMed 
    involved_in regulation of appetite PubMed 
    acts_upstream_of_or_within regulation of inflammatory response PubMed 
    acts_upstream_of_or_within regulation of neutrophil chemotaxis PubMed 
    involved_in response to endoplasmic reticulum stress PubMed 
    acts_upstream_of_or_within response to exogenous dsRNA PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide PubMed 
    involved_in response to muramyl dipeptide  
    acts_upstream_of_or_within response to muramyl dipeptide PubMed 
    involved_in response to muramyl dipeptide PubMed 
    acts_upstream_of_or_within response to muramyl dipeptide PubMed 
    involved_in response to muramyl dipeptide PubMed 
    involved_in response to muramyl dipeptide  
    involved_in response to muramyl dipeptide  
    involved_in response to nutrient  
    acts_upstream_of_or_within response to peptidoglycan PubMed 
    acts_upstream_of_or_within response to peptidoglycan PubMed 
    involved_in signal transduction PubMed 
    acts_upstream_of stress-activated MAPK cascade PubMed 
    involved_in temperature homeostasis PubMed 
    acts_upstream_of toll-like receptor 2 signaling pathway PubMed 
    acts_upstream_of tumor necrosis factor production PubMed 
    acts_upstream_of tumor necrosis factor production PubMed 
    acts_upstream_of tumor necrosis factor production PubMed 
    acts_upstream_of type II interferon production PubMed 
    acts_upstream_of xenophagy PubMed 
    Items 1 - 25 of 170
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in cell surface  
    located_in cell surface  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoskeleton  
    located_in cytoskeleton  
    is_active_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in extrinsic component of plasma membrane  
    is_active_in extrinsic component of plasma membrane  
    located_in mitochondrion  
    located_in phagocytic vesicle  
    located_in phagocytic vesicle  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in vesicle  
    located_in vesicle  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    nucleotide-binding oligomerization domain-containing protein 2
    Names
    caspase recruitment domain family, member 15
    caspase recruitment domain-containing protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145857.2NP_665856.2  nucleotide-binding oligomerization domain-containing protein 2

      See identical proteins and their annotated locations for NP_665856.2

      Status: VALIDATED

      Source sequence(s)
      AC156937
      Consensus CDS
      CCDS52632.1
      UniProtKB/TrEMBL
      Q80SY8, Q80SY9, Q80SZ8
      Related
      ENSMUSP00000113773.2, ENSMUST00000118370.8
      Conserved Domains (4) summary
      cd00116
      Location:753980
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:768789
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      89373943..89415103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248390.3XP_011246692.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011246692.1

      UniProtKB/TrEMBL
      Q80SZ8
      Conserved Domains (6) summary
      sd00033
      Location:768789
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      pfam17776
      Location:576730
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:518574
      NOD2_WH; NOD2 winged helix domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl39015
      Location:753981
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    2. XM_036154050.1XP_036009943.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      Q80SZ8
      Conserved Domains (6) summary
      sd00033
      Location:762780
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      pfam17776
      Location:576730
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:518574
      NOD2_WH; NOD2 winged helix domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl39015
      Location:753979
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    3. XM_006531029.5XP_006531092.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      Q80SZ8
      Conserved Domains (6) summary
      sd00033
      Location:762780
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      pfam17776
      Location:576730
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:518574
      NOD2_WH; NOD2 winged helix domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl39015
      Location:753934
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    4. XM_036154051.1XP_036009944.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      Q3V2V8
      Related
      ENSMUST00000124091.2
      Conserved Domains (4) summary
      pfam05729
      Location:266436
      NACHT; NACHT domain
      pfam17776
      Location:576730
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:518574
      NOD2_WH; NOD2 winged helix domain
      cl14633
      Location:787
      DD; Death Domain Superfamily of protein-protein interaction domains
    5. XM_006531028.4XP_006531091.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531091.1

      UniProtKB/TrEMBL
      Q80SZ8
      Conserved Domains (6) summary
      sd00033
      Location:768789
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:266436
      NACHT; NACHT domain
      pfam17776
      Location:576730
      NLRC4_HD2; NLRC4 helical domain HD2
      pfam17779
      Location:518574
      NOD2_WH; NOD2 winged helix domain
      cl14633
      Location:107186
      DD; Death Domain Superfamily of protein-protein interaction domains
      cl39015
      Location:753981
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
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