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    4930451I11Rik RIKEN cDNA 4930451I11 gene [ Mus musculus (house mouse) ]

    Gene ID: 78118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    4930451I11Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 4930451I11 geneprovided by MGI
    Primary source
    MGI:MGI:1925368
    See related
    Ensembl:ENSMUSG00000045989 AllianceGenome:MGI:1925368
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fimp
    Summary
    Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in extracellular region and plasma membrane. Orthologous to human C16orf92 (chromosome 16 open reading frame 92). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 30.6) See more
    Orthologs
    human all
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    Genomic context

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    See 4930451I11Rik in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126429640..126430712, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126830468..126831540, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10476 Neighboring gene predicted gene, 57854 Neighboring gene aldolase A, fructose-bisphosphate Neighboring gene TLC domain containing 3B Neighboring gene double C2, alpha Neighboring gene INO80 complex subunit E Neighboring gene STARR-positive B cell enhancer ABC_E8843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134005673-134005856 Neighboring gene HIRA interacting protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of the initial methionine codon of the Tmem95 gene causes subfertility, but not complete infertility, in male mice. Inoue N, et al. Biol Reprod, 2022 Mar 19. PMID 34982145
    2. Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice. Fujihara Y, et al. Proc Natl Acad Sci U S A, 2020 Apr 28. PMID 32295885, Free PMC Article
    3. Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Matsumura T, et al. Front Cell Dev Biol, 2021. PMID 35096839, Free PMC Article
    4. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fertilization-influencing membrane protein
    Names
    uncharacterized protein C16orf92 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183131.3 → NP_898954.2  fertilization-influencing membrane protein precursor

      Status: PROVISIONAL

      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS52402.1
      UniProtKB/Swiss-Prot
      E9Q9R3, Q8CEL4
      Related
      ENSMUSP00000049614.4, ENSMUST00000061695.5
      Conserved Domains (1) summary
      pfam17672
      Location:24 → 111
      DUF5589; Family of unknown function (DUF5589)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126429640..126430712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508347.3 → XP_006508410.1  fertilization-influencing membrane protein isoform X1

      Conserved Domains (1) summary
      pfam17672
      Location:24 → 105
      DUF5589; Family of unknown function (DUF5589)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q9R3.1 GenPept UniProtKB/Swiss-Prot:E9Q9R3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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