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    Adam26b a disintegrin and metallopeptidase domain 26B [ Mus musculus (house mouse) ]

    Gene ID: 382007, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adam26bprovided by MGI
    Official Full Name
    a disintegrin and metallopeptidase domain 26Bprovided by MGI
    Primary source
    MGI:MGI:3588304
    See related
    Ensembl:ENSMUSG00000063900 AllianceGenome:MGI:3588304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be active in external side of plasma membrane and sperm head plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 5.3) See more
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    Genomic context

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    See Adam26b in Genome Data Viewer
    Location:
    8 A4; 8 23.99 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (43972901..43981174, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (43519864..43528137, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21325 Neighboring gene STARR-seq mESC enhancer starr_21328 Neighboring gene zinc finger protein 42 Neighboring gene STARR-seq mESC enhancer starr_21332 Neighboring gene predicted gene, 53410 Neighboring gene STARR-seq mESC enhancer starr_21334 Neighboring gene ADAM metallopeptidase domain 26A Neighboring gene STARR-seq mESC enhancer starr_21335 Neighboring gene STARR-seq mESC enhancer starr_21336 Neighboring gene a disintegrin and metallopeptidase domain 26B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization and comparative genomic analysis of intronless Adams with testicular gene expression. Choi I, et al. Genomics, 2004 Apr. PMID 15028286
    2. Positive selection in the adhesion domain of Mus sperm Adam genes through gene duplications and function-driven gene complex formations. Grayson P, et al. BMC Evol Biol, 2013 Sep 30. PMID 24079728, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm head plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    a disintegrin and metalloprotease domain 26b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009547.2 → NP_001009547.1  a disintegrin and metalloprotease domain 26b precursor

      See identical proteins and their annotated locations for NP_001009547.1

      Status: VALIDATED

      Source sequence(s)
      AC134907, AK015931
      Consensus CDS
      CCDS22268.1
      UniProtKB/TrEMBL
      Q6IMH6
      Related
      ENSMUSP00000079032.4, ENSMUST00000080135.5
      Conserved Domains (5) summary
      smart00608
      Location:477 → 613
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:195 → 383
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:401 → 474
      Disintegrin; Disintegrin
      pfam01421
      Location:195 → 385
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:39 → 144
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      43972901..43981174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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