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    LINC01234 long intergenic non-protein coding RNA 1234 [ Homo sapiens (human) ]

    Gene ID: 100506465, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01234provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1234provided by HGNC
    Primary source
    HGNC:HGNC:49757
    See related
    Ensembl:ENSG00000249550 AllianceGenome:HGNC:49757
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MBOP; LCAL84; onco-lncRNA-32
    Expression
    Biased expression in brain (RPKM 1.1) and testis (RPKM 0.5) See more
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    Genomic context

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    See LINC01234 in Genome Data Viewer
    Location:
    12q24.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (113744577..113773683, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (113720398..113749505, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (114182382..114211488, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114079299-114079817 Neighboring gene uncharacterized LOC105369991 Neighboring gene VISTA enhancer hs1571 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114132877-114133376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114140827-114141326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114206803-114207314 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114215183-114215682 Neighboring gene NANOG hESC enhancer GRCh37_chr12:114222326-114222862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114243165-114243665 Neighboring gene dynein light chain LC8-type 1 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114255753-114256680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114256681-114257606 Neighboring gene RNA binding motif protein 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114294867-114295368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:114295369-114295868 Neighboring gene uncharacterized LOC124903025 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:114300792-114301991

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Silencing LINC01234 represses pancreatic cancer progression by inhibiting the malignant phenotypes of pancreatic cancer cells. Song Y, et al. Immunobiology, 2022 Nov. PMID 36343541
    2. Oncogenic roles of LINC01234 in various forms of human cancer. Kong M, et al. Biomed Pharmacother, 2022 Oct. PMID 36030582
    3. LINC01234 Accelerates the Progression of Breast Cancer via the miR-525-5p/Cold Shock Domain-Containing E1 Axis. Yu J, et al. Dis Markers, 2022. PMID 35923244, Free PMC Article
    4. Oncopeptide MBOP Encoded by LINC01234 Promotes Colorectal Cancer through MAPK Signaling Pathway. Tang C, et al. Cancers (Basel), 2022 May 9. PMID 35565466, Free PMC Article
    5. LINC01234 aggravates cell growth and migration of triple-negative breast cancer by activating the Wnt pathway. Xiao F, et al. Environ Toxicol, 2021 Oct. PMID 34173712

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC01234 promoted malignant behaviors of breast cancer cells via hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway.
      Title: LINC01234 promoted malignant behaviors of breast cancer cells via hsa-miR-30c-2-3p/CCT4/mTOR signaling pathway.
    2. The Role of the LINC01234/miR-433-3p/GRB2 ceRNA Network in NSCLC Cell Malignant Proliferation.
      Title: The Role of the LINC01234/miR-433-3p/GRB2 ceRNA Network in NSCLC Cell Malignant Proliferation.
    3. Silencing LINC01234 represses pancreatic cancer progression by inhibiting the malignant phenotypes of pancreatic cancer cells.
      Title: Silencing LINC01234 represses pancreatic cancer progression by inhibiting the malignant phenotypes of pancreatic cancer cells.
    4. Oncogenic roles of LINC01234 in various forms of human cancer.
      Title: Oncogenic roles of LINC01234 in various forms of human cancer.
    5. LINC01234 Accelerates the Progression of Breast Cancer via the miR-525-5p/Cold Shock Domain-Containing E1 Axis.
      Title: LINC01234 Accelerates the Progression of Breast Cancer via the miR-525-5p/Cold Shock Domain-Containing E1 Axis.
    6. LINC01234 aggravates cell growth and migration of triple-negative breast cancer by activating the Wnt pathway.
      Title: LINC01234 aggravates cell growth and migration of triple-negative breast cancer by activating the Wnt pathway.
    7. Long noncoding RNA LINC01234 promoted cell proliferation and invasion via miR-1284/TRAF6 axis in colorectal cancer.
      Title: Long noncoding RNA LINC01234 promoted cell proliferation and invasion via miR-1284/TRAF6 axis in colorectal cancer.
    8. Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis.
      Title: Integrative Analysis of NSCLC Identifies LINC01234 as an Oncogenic lncRNA that Interacts with HNRNPA2B1 and Regulates miR-106b Biogenesis.
    9. Function and regulation annotation of up-regulated long non-coding RNA LINC01234 in gastric cancer.
      Title: Function and regulation annotation of up-regulated long non-coding RNA LINC01234 in gastric cancer.
    10. Up-regulated LINC01234 promotes non-small-cell lung cancer cell metastasis by activating VAV3 and repressing BTG2 expression.
      Title: Up-regulated LINC01234 promotes non-small-cell lung cancer cell metastasis by activating VAV3 and repressing BTG2 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • MEK1-binding oncopeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110025.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon compared to variant 1.
      Source sequence(s)
      AC009731
      Related
      ENST00000547963.1

    2. NR_110026.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC009731

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      113744577..113773683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      113720398..113749505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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