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    NRBP1 nuclear receptor binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 29959, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NRBP1provided by HGNC
    Official Full Name
    nuclear receptor binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:7993
    See related
    Ensembl:ENSG00000115216 MIM:606010; AllianceGenome:HGNC:7993
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MADM; NRBP; BCON3; MUDPNP
    Summary
    Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in endomembrane system. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in esophagus (RPKM 41.1), testis (RPKM 38.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NRBP1 in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27427790..27442259)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27470161..27484612)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27650657..27665126)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27601343-27602213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11297 Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1G Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27618171-27618672 Neighboring gene ferritin heavy chain 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11300 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11302 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27665383-27665925 Neighboring gene keratinocyte associated protein 3 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27676057-27677256 Neighboring gene intraflagellar transport 172 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27681686-27682885 Neighboring gene RNA, U6 small nuclear 986, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. NRBP1 promotes malignant phenotypes of glioblastoma by regulating PI3K/Akt activation. Zhang A, et al. Cancer Med, 2024 Aug. PMID 39149873, Free PMC Article
    2. The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer. Yang X, et al. Oncogene, 2023 Mar. PMID 36693952, Free PMC Article
    3. [A nurse with the drug addicts]. Martinez P. Rev Infirm, 1976 Jul-Sep. PMID 1048605
    4. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. Hooper JD, et al. Genomics, 2000 May 15. PMID 10843813
    5. High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth. Ruiz C, et al. Prostate, 2012 Nov. PMID 22473923

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NRBP1 promotes malignant phenotypes of glioblastoma by regulating PI3K/Akt activation.
      Title: NRBP1 promotes malignant phenotypes of glioblastoma by regulating PI3K/Akt activation.
    2. The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis.
      Title: The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis.
    3. The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
      Title: The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
    4. Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis.
      Title: Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis.
    5. CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1.
      Title: CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1.
    6. NRBP1-Containing CRL2/CRL4A Regulates Amyloid beta Production by Targeting BRI2 and BRI3 for Degradation.
      Title: NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation.
    7. THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.
      Title: THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.
    8. Overexpression of NRBP1 triggers the activation of caspase-dependent intrinsic apoptosis, which promotes colorectal cancer cell apoptosis and inhibits cell proliferation and colony formation. High NRBP1 expression levels are associated with longer overall survival and disease-free survival.
      Title: Nuclear receptor binding protein 1 correlates with better prognosis and induces caspase-dependent intrinsic apoptosis through the JNK signalling pathway in colorectal cancer.
    9. Study have identified a gout risk gene, NRBP1,and demonstrated that increased NRBP1 expression in gout patients may be regulated through methylation-dependent binding of TFAP2A to the B1 region, a 72 bp upstream of NRBP1 transcription start site.
      Title: DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding.
    10. The present study deals with the molecular modeling of the viral protein (NS3 of DENV1-4), the host protein (NRBP) and their interactions through protein-protein docking study.
      Title: Insight into structural organization and protein-protein interaction of non structural 3 (NS3) proteins from dengue serotypes.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of nuclear receptor binding protein 1 (NRBP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NRBP1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27109, FLJ35541

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    nuclear receptor-binding protein
    Names
    multiple domain putative nuclear protein
    myeloid leukemia factor 1 adaptor molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321357.2 → NP_001308286.1  nuclear receptor-binding protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC074117, AK122664, BC001221
      Consensus CDS
      CCDS1753.1
      UniProtKB/Swiss-Prot
      B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
      UniProtKB/TrEMBL
      B4DW31
      Related
      ENSP00000233557.3, ENST00000233557.7
      Conserved Domains (1) summary
      cd14034
      Location:60 → 334
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

    2. NM_001321358.2 → NP_001308287.1  nuclear receptor-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      Consensus CDS
      CCDS82433.1
      UniProtKB/TrEMBL
      B4DW31, F8W6G1
      Conserved Domains (1) summary
      cd14034
      Location:60 → 342
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

    3. NM_001321359.2 → NP_001308288.1  nuclear receptor-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      Consensus CDS
      CCDS82433.1
      UniProtKB/TrEMBL
      B4DW31, F8W6G1
      Related
      ENSP00000369192.3, ENST00000379863.7
      Conserved Domains (1) summary
      cd14034
      Location:60 → 342
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

    4. NM_001321361.2 → NP_001308290.1  nuclear receptor-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      UniProtKB/TrEMBL
      B4DW31
      Conserved Domains (2) summary
      smart00220
      Location:83 → 332
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14034
      Location:60 → 341
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

    5. NM_001321362.2 → NP_001308291.1  nuclear receptor-binding protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      UniProtKB/TrEMBL
      B4DW31
      Conserved Domains (1) summary
      cd14034
      Location:60 → 333
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

    6. NM_001321363.2 → NP_001308292.1  nuclear receptor-binding protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC074117, BC001221
      UniProtKB/TrEMBL
      B4DW31
      Conserved Domains (1) summary
      cl21453
      Location:60 → 302
      PKc_like; Protein Kinases, catalytic domain

    7. NM_013392.4 → NP_037524.1  nuclear receptor-binding protein isoform 1

      See identical proteins and their annotated locations for NP_037524.1

      Status: VALIDATED

      Source sequence(s)
      BC001221, BQ949042
      Consensus CDS
      CCDS1753.1
      UniProtKB/Swiss-Prot
      B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
      UniProtKB/TrEMBL
      B4DW31
      Related
      ENSP00000369181.3, ENST00000379852.8
      Conserved Domains (1) summary
      cd14034
      Location:60 → 334
      PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27427790..27442259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444036.1 → XP_047299992.1  nuclear receptor-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
      UniProtKB/TrEMBL
      B4DW31

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27470161..27484612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341567.1 → XP_054197542.1  nuclear receptor-binding protein isoform X1

      UniProtKB/Swiss-Prot
      B3KV40, D6W558, Q53FZ5, Q96SU3, Q9UHY1
      UniProtKB/TrEMBL
      B4DW31
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UHY1.1 GenPept UniProtKB/Swiss-Prot:Q9UHY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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