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    PAX8-AS1 PAX8 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 654433, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PAX8-AS1provided by HGNC
    Official Full Name
    PAX8 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:49271
    See related
    Ensembl:ENSG00000189223 AllianceGenome:HGNC:49271
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in thyroid (RPKM 22.6), adrenal (RPKM 9.3) and 19 other tissues See more
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    Genomic context

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    See PAX8-AS1 in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113235527..113267023)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113662091..113693574)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113993104..114024600)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16412 Neighboring gene interleukin 1 receptor antagonist Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11879 Neighboring gene Sharpr-MPRA regulatory region 7144 Neighboring gene uncharacterized LOC124907872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:113929890-113930390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:113930391-113930891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16415 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16417 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 2961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11881 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:113998497-113999696 Neighboring gene paired box 8 Neighboring gene PAX8 promoter region Neighboring gene uncharacterized LOC105373567 Neighboring gene long intergenic non-protein coding RNA 2966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:114099097-114099596 Neighboring gene uncharacterized LOC124906070

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Baicalein inhibits breast cancer growth via activating a novel isoform of the long noncoding RNA PAX8-AS1-N. Yu X, et al. J Cell Biochem, 2018 Aug. PMID 29693272
    2. Long non-coding RNA PAX8-AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia. Bahari G, et al. Biomed Rep, 2018 Feb. PMID 29435279, Free PMC Article
    3. Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism. Elsayed OM, et al. Sci Rep, 2023 Jan 2. PMID 36593237, Free PMC Article
    4. Association between PAX8AS1 (rs4848320 C > T, rs1110839 G > T, and rs6726151 T > G) and MEG3 (rs7158663) gene polymorphisms and non-Hodgkin lymphoma risk. Mirzazadeh S, et al. Nucleosides Nucleotides Nucleic Acids, 2022. PMID 35938744
    5. PAX8/PAX8-AS1 DNA methylation levels are associated with objective sleep duration in persons with unexplained hypersomnolence using a deep phenotyping approach. Plante DT, et al. Sleep, 2021 Oct 11. PMID 34145460

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism.
      Title: Association of LncRNA-PAX8-AS1 and LAIR-2 polymorphisms along with their expression with clinical and subclinical hypothyroidism.
    2. Association between PAX8AS1 (rs4848320 C > T, rs1110839 G > T, and rs6726151 T > G) and MEG3 (rs7158663) gene polymorphisms and non-Hodgkin lymphoma risk.
      Title: Association between PAX8AS1 (rs4848320 C > T, rs1110839 G > T, and rs6726151 T > G) and MEG3 (rs7158663) gene polymorphisms and non-Hodgkin lymphoma risk.
    3. PAX8/PAX8-AS1 DNA methylation levels are associated with objective sleep duration in persons with unexplained hypersomnolence using a deep phenotyping approach.
      Title: PAX8/PAX8-AS1 DNA methylation levels are associated with objective sleep duration in persons with unexplained hypersomnolence using a deep phenotyping approach.
    4. Inhibition of lncRNA-PAX8-AS1-N directly associated with VEGF/TGF-beta1/8-OhdG enhances podocyte apoptosis in diabetic nephropathy.
      Title: Inhibition of lncRNA-PAX8-AS1-N directly associated with VEGF/TGF-β1/8-OhdG enhances podocyte apoptosis in diabetic nephropathy.
    5. Expression levels of PAX8AS1:28 and PAX8 were lower in papillary thyroid carcinoma (PTC) tissue and PTC cells than those in healthy tissue and cells. Expression level of MYC was higher in PTC cells than that in normal cells. PAX8AS1:28 silencing reduced the expression level of PAX8 and promoted tumor cell growth, while PAX8AS1:28 overexpression increased the expression level of PAX8 and inhibited tumor cell growth.
      Title: MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8‑AS1:28.
    6. results demonstrated that PAX8-AS1-N activation mediated the anti-cancer effects of baicalein via regulating miR-17-5p, and suggested that baicalein and enhancing PAX8-AS1-N would be potential therapeutic strategies against breast cancer.
      Title: Baicalein inhibits breast cancer growth via activating a novel isoform of the long noncoding RNA PAX8-AS1-N.
    7. Study suggested that PAX8 eQTLs SNPs (rs4848320 and rs1110839) located in lncRNA PAX8-AS1 might predict decreased risk of cervical cancer.
      Title: Expression quantitative trait loci in long non-coding RNA PAX8-AS1 are associated with decreased risk of cervical cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Clone Names

    • FLJ17200, FLJ31793, FLJ44467, DKFZp547P134, DKFZp686E10196

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015377.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      BC036699, BF056746
      Related
      ENST00000436293.6

    2. NR_047570.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several segments and has an alternate terminal exon compared to variant 1.
      Source sequence(s)
      AK056052, AK130275, AY007128, CA416382, DA573927

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      113235527..113267023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      113662091..113693574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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