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    Uros uroporphyrinogen III synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309070, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Urosprovided by RGD
    Official Full Name
    uroporphyrinogen III synthaseprovided by RGD
    Primary source
    RGD:1310396
    See related
    EnsemblRapid:ENSRNOG00000017810 AllianceGenome:RGD:1310396
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables folic acid binding activity. Contributes to uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to arsenic-containing substance; response to platinum ion; and uroporphyrinogen III biosynthetic process. Predicted to be active in cytosol. Used to study cutaneous porphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 79.8), Muscle (RPKM 45.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Uros in Genome Data Viewer
    Location:
    1q41
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (197920827..197943183, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (188490832..188513659, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (205755766..205778170, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene erythroid differentiation regulatory factor 1 Neighboring gene matrix metallopeptidase 21 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of his-tagged rat uroporphyrinogen III synthase wild-type and variant enzymes. Li N, et al. Protein J, 2007 Dec. PMID 17763925
    2. Alterations in renal heme biosynthesis during metal nephrotoxicity. Oskarsson A, et al. Ann N Y Acad Sci, 1987. PMID 3327431
    3. Biosynthesis of uroporphyrinogens. Interaction among 2-(aminomethyl)bilanes and the enzymatic system. Sburlati A, et al. Biochemistry, 1983 Aug 16. PMID 6604545
    4. Irgasan DP 300 (5-chloro-2-(2,4-dichlorophenoxy)-phenol) induces cytochrome P450s and inhibits haem biosynthesis in rat hepatocytes cultured on Matrigel. Jinno H, et al. Xenobiotica, 1997 Jul. PMID 9253145
    5. Point mutations in the uroporphyrinogen III synthase gene in congenital erythropoietic porphyria (Günther's disease). Deybach JC, et al. Blood, 1990 May 1. PMID 2331520

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables folic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to uroporphyrinogen-III synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uroporphyrinogen-III synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amine stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to arsenic-containing substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in heme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme B biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme O biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within porphyrin-containing compound biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to platinum ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in uroporphyrinogen III biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uroporphyrinogen III biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uroporphyrinogen III biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uroporphyrinogen-III synthase
    Names
    urogen III synthase
    uroporphyrinogen III co-synthase
    NP_001012068.1
    XP_008758113.1
    XP_017444718.1
    XP_063119843.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012068.1 → NP_001012068.1  uroporphyrinogen-III synthase

      See identical proteins and their annotated locations for NP_001012068.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083730
      UniProtKB/TrEMBL
      F7ET42, Q5XIF2
      Conserved Domains (1) summary
      cd06578
      Location:3 → 255
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      197920827..197943183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263773.1 → XP_063119843.1  uroporphyrinogen-III synthase isoform X2

      UniProtKB/TrEMBL
      F7ET42, Q5XIF2

    2. XM_017589229.3 → XP_017444718.1  uroporphyrinogen-III synthase isoform X1

      Conserved Domains (1) summary
      cd06578
      Location:3 → 263
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

    3. XM_008759891.3 → XP_008758113.1  uroporphyrinogen-III synthase isoform X1

      See identical proteins and their annotated locations for XP_008758113.1

      Related
      ENSRNOP00000024278.4, ENSRNOT00000024279.6
      Conserved Domains (1) summary
      cd06578
      Location:3 → 263
      HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...
    Nucleotide Protein Strain
    Heading Accession and Version

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