Dnase2b deoxyribonuclease II beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnase2bprovided by MGI
Official Full Name: deoxyribonuclease II betaprovided by MGI
Primary source: MGI:MGI:1913283
See related: Ensembl:ENSMUSG00000028185 AllianceGenome:MGI:1913283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlad; DnaseIIb
Summary: Enables DNA endonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Located in cytoplasm and extracellular region. Is expressed in ganglia; medulla oblongata basal plate mantle layer; and ventral grey horn. Used to study cataract. Orthologous to human DNASE2B (deoxyribonuclease 2 beta). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in liver E18 (RPKM 1.3), liver adult (RPKM 0.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H2; 3 72.0 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (146275488..146322815, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (146569733..146617060, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data identify DNase 2 as the predominant DNase on the mammalian skin surface and indicate that its activity is primarily targeted to exogenous DNA.
Title: DNase 2 is the main DNA-degrading enzyme of the stratum corneum.
DNase II-like acid DNase is synthesized as a precursor with a signal sequence, and is localized to lysosomes. DNase II-like acid DNase mRNA was found in cortical fiber cells but not epithelial cells
Title: Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens.
gene lie head-to-head with the urate oxidase gene
Title: Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase.
The DLAD-/- mice develop cataracts of the nucleus lentis, and their response to light on electroretinograms is severely reduced; these results indicate that DLAD is responsible for the degradation of nuclear DNA during lens cell differentiation
Title: Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

UOX (e-PCR)
- UniSTS:264969

43.MMHAP31FLG4.seq (e-PCR)
- UniSTS:124499

AI526873 (e-PCR)
- UniSTS:164229

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables deoxyribonuclease II activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyribonuclease II activity	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease II activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: deoxyribonuclease-2-beta

Names: DNase II beta; DNase II-like acid DNase; DNase2-like acid DNase; deoxyribonuclease DLAD; endonuclease DLAD

NP_001398343.1

EC 3.1.22.1

NP_001398344.1

EC 3.1.22.1

NP_064341.3

EC 3.1.22.1

XP_011238473.1

EC 3.1.22.1

XP_011238474.1

EC 3.1.22.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411414.1 → NP_001398343.1 deoxyribonuclease-2-beta precursor

Status: VALIDATED

Source sequence(s)

AC141632

UniProtKB/Swiss-Prot

Q8C589, Q9QY48

Related

ENSMUSP00000029836.5, ENSMUST00000029836.9
NM_001411415.1 → NP_001398344.1 deoxyribonuclease-2-beta precursor

Status: VALIDATED

Source sequence(s)

AC141632

UniProtKB/Swiss-Prot

Q8C589, Q9QY48
NM_019957.5 → NP_064341.3 deoxyribonuclease-2-beta precursor

Status: VALIDATED

Source sequence(s)

AC141632

Consensus CDS

CCDS17904.1

UniProtKB/Swiss-Prot

Q8C589, Q9QY48

Related

ENSMUSP00000142872.2, ENSMUST00000200633.2

Conserved Domains (1) summary

pfam03265
Location:29 → 342

DNase_II; Deoxyribonuclease II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

146275488..146322815 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240172.2 → XP_011238474.1 deoxyribonuclease-2-beta isoform X1

UniProtKB/Swiss-Prot

Q8C589, Q9QY48

Conserved Domains (1) summary

pfam03265
Location:29 → 342

DNase_II; Deoxyribonuclease II
XM_011240171.2 → XP_011238473.1 deoxyribonuclease-2-beta isoform X1

UniProtKB/Swiss-Prot

Q8C589, Q9QY48

Conserved Domains (1) summary

pfam03265
Location:29 → 342

DNase_II; Deoxyribonuclease II