Atp11c ATPase, class VI, type 11C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp11cprovided by MGI
Official Full Name: ATPase, class VI, type 11Cprovided by MGI
Primary source: MGI:MGI:1859661
See related: Ensembl:ENSMUSG00000062949 AllianceGenome:MGI:1859661
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ig; A330005H02Rik
Summary: Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Involved in phospholipid translocation; positive regulation of B cell differentiation; and pre-B cell differentiation. Predicted to be located in early endosome membrane; endoplasmic reticulum membrane; and recycling endosome membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Is expressed in choroid invagination; cortical plate; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia. Orthologous to human ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E14 (RPKM 7.2), whole brain E14.5 (RPKM 6.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A6; X 33.5 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (59268643..59450041, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (60223283..60404853, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation.
Title: ATP11C promotes the differentiation of pre-B cells into immature B cells but does not affect their IL-7-dependent proliferation.
The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane.
Title: The cytoplasmic C-terminal region of the ATP11C variant determines its localization at the polarized plasma membrane.
ATP11A and ATP11C in precursor B cells are essential for rapidly internalizing PtdSer from the cell surface to prevent the cells' engulfment by macrophages.
Title: Phospholipid flippases enable precursor B cells to flee engulfment by macrophages.
essential for basolateral membrane localization of multiple bile salt transport proteins in central hepatocytes
Title: Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice.
a mutation in ATP11C resulted in diminished flippase activity in immune cells, suggesting ATP11C is a flippase that selectively transports phosphatidylserine and phosphatidylethanolamine from the outer leaflet of the plasma membrane to the inner leaflet.
Title: ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes.
an essential role for ATP11C in erythrocyte morphology and survival and provide a new candidate for the rare inherited blood disorder stomatocytosis with uncompensated anemia.
Title: Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span.
Mutation of the X-linked gene Atp11c, which encodes a paralogous P4-type ATPase, precludes B-cell development in the adult bone marrow, but also causes hyperbilirubinemia.
Title: X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C.
A defect is ATP11C results inlower B-cell phosphatidylserine flippase activity and disrupts B-cell development and antibody production and also causes hepatocellular carcinoma.
Title: ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes.
ATP11C is redundant during B cell development in the fetal liver but essential in the context of adult bone marrow where it is required for optiml responses to IL-7 and sustained expression of Ebf1.
Title: The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (4) 1 citation
Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-51b11 (e-PCR)
- UniSTS:257897

AI315324 (e-PCR)
- UniSTS:160883

px-56b4 (e-PCR)
- UniSTS:257928

px-7g6 (e-PCR)
- UniSTS:258200

NoName (e-PCR)
- UniSTS:238030

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled intramembrane lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine flippase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine flippase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine flippase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine floppase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid translocation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of phospholipid-translocating ATPase complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipid-transporting ATPase 11C

Names: Atpase 11c, p type; P4-ATPase flippase complex alpha subunit ATP11C; probable phospholipid-transporting ATPase 11C

NP_001001798.1

EC 7.6.2.1

NP_001032952.1

EC 7.6.2.1

NP_001345931.1

EC 7.6.2.1

XP_006528153.1

EC 7.6.2.1

XP_006528154.1

EC 7.6.2.1

XP_006528156.1

EC 7.6.2.1

XP_006528158.1

EC 7.6.2.1

XP_006528159.1

EC 7.6.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001798.3 → NP_001001798.1 phospholipid-transporting ATPase 11C isoform b

Status: VALIDATED

Source sequence(s)

BC106087, BY017646, CO042050, CU682339

Consensus CDS

CCDS40987.1

UniProtKB/TrEMBL

E9QKK8, F6Q8D3

Related

ENSMUSP00000033480.7, ENSMUST00000033480.13

Conserved Domains (8) summary

TIGR01652
Location:40 → 1088

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:97 → 182

E1-E2_ATPase; E1-E2 ATPase

pfam04547
Location:260 → 374

Anoctamin; Calcium-activated chloride channel

pfam13246
Location:468 → 572

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:37 → 90

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:842 → 1089

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl14615
Location:555 → 674

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

cl21460
Location:811 → 840

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001037863.2 → NP_001032952.1 phospholipid-transporting ATPase 11C isoform a

See identical proteins and their annotated locations for NP_001032952.1

Status: VALIDATED

Source sequence(s)

BC106087, BY017646, CO042050, CU682339

Consensus CDS

CCDS40988.1

UniProtKB/Swiss-Prot

Q3KQR4, Q9QZW0

UniProtKB/TrEMBL

F6Q8D3

Related

ENSMUSP00000099066.3, ENSMUST00000101527.3

Conserved Domains (2) summary

cd02073
Location:42 → 974

P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

pfam02322
Location:993 → 1083

Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
NM_001359002.1 → NP_001345931.1 phospholipid-transporting ATPase 11C isoform c

Status: VALIDATED

Source sequence(s)

AL670778, BX284683, CO042050, CU682339

UniProtKB/TrEMBL

F6Q8D3

Conserved Domains (1) summary

cd02073
Location:42 → 974

P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

59268643..59450041 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006528091.5 → XP_006528154.1 phospholipid-transporting ATPase 11C isoform X1

See identical proteins and their annotated locations for XP_006528154.1

UniProtKB/Swiss-Prot

Q3KQR4, Q9QZW0

UniProtKB/TrEMBL

F6Q8D3

Conserved Domains (2) summary

cd02073
Location:42 → 974

P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

pfam02322
Location:993 → 1083

Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
XM_006528090.5 → XP_006528153.1 phospholipid-transporting ATPase 11C isoform X1

See identical proteins and their annotated locations for XP_006528153.1

UniProtKB/Swiss-Prot

Q3KQR4, Q9QZW0

UniProtKB/TrEMBL

F6Q8D3

Conserved Domains (2) summary

cd02073
Location:42 → 974

P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

pfam02322
Location:993 → 1083

Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
XM_006528095.4 → XP_006528158.1 phospholipid-transporting ATPase 11C isoform X3

See identical proteins and their annotated locations for XP_006528158.1

UniProtKB/TrEMBL

F6Q8D3

Conserved Domains (2) summary

cd02073
Location:42 → 974

P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

pfam02322
Location:993 → 1083

Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II
XM_006528093.3 → XP_006528156.1 phospholipid-transporting ATPase 11C isoform X2

See identical proteins and their annotated locations for XP_006528156.1

UniProtKB/TrEMBL

F6Q8D3

Conserved Domains (1) summary

cd02073
Location:42 → 974

P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
XM_006528096.3 → XP_006528159.1 phospholipid-transporting ATPase 11C isoform X3

See identical proteins and their annotated locations for XP_006528159.1

UniProtKB/TrEMBL

F6Q8D3

Conserved Domains (2) summary

cd02073
Location:42 → 974

P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

pfam02322
Location:993 → 1083

Cyt_bd_oxida_II; Cytochrome bd terminal oxidase subunit II