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    Arl5c ADP-ribosylation factor-like 5C [ Mus musculus (house mouse) ]

    Gene ID: 217151, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arl5cprovided by MGI
    Official Full Name
    ADP-ribosylation factor-like 5Cprovided by MGI
    Primary source
    MGI:MGI:3028577
    See related
    Ensembl:ENSMUSG00000038352 AllianceGenome:MGI:3028577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arl12
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Is expressed in ileum; immune system; male reproductive gland or organ; and midbrain. Orthologous to human ARL5C (ARF like GTPase 5C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 71.3), spleen adult (RPKM 13.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Arl5c in Genome Data Viewer
    Location:
    11 D; 11 61.47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97880404..97887109, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97989575..97996285, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene plexin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3012 Neighboring gene STARR-positive B cell enhancer ABC_E5273 Neighboring gene nuclear encoded tRNA cysteine 55 (anticodon GCA) Neighboring gene nuclear encoded tRNA cysteine 54 (anticodon GCA) Neighboring gene STARR-positive B cell enhancer ABC_E10711 Neighboring gene STARR-positive B cell enhancer ABC_E5274 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97861691-97862052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97864016-97864125 Neighboring gene STARR-positive B cell enhancer ABC_E11491 Neighboring gene calcium channel, voltage-dependent, beta 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E3013 Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene STARR-positive B cell enhancer ABC_E9372

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Clone Names

    • MGC73657

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 5C
    Names
    ADP-ribosylation factor-like 12
    ADP-ribosylation factor-like 5C protein
    ADP-ribosylation factor-like protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207231.1 → NP_997114.1  ADP-ribosylation factor-like protein 5C

      See identical proteins and their annotated locations for NP_997114.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      BC065791
      Consensus CDS
      CCDS25334.1
      UniProtKB/Swiss-Prot
      Q3TBK5, Q6P068
      Related
      ENSMUSP00000037214.10, ENSMUST00000042971.16
      Conserved Domains (2) summary
      cd04153
      Location:3 → 172
      Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases
      COG1100
      Location:18 → 138
      Gem1; GTPase SAR1 family domain [General function prediction only]

    RNA

    1. NR_152188.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC065791

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97880404..97887109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248941.4 → XP_011247243.1  ADP-ribosylation factor-like protein 5C isoform X4

      UniProtKB/TrEMBL
      A2A541
      Conserved Domains (1) summary
      cl38936
      Location:3 → 86
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_011248939.4 → XP_011247241.1  ADP-ribosylation factor-like protein 5C isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:3 → 120
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_036156589.1 → XP_036012482.1  ADP-ribosylation factor-like protein 5C isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:3 → 144
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_030245868.2 → XP_030101728.1  ADP-ribosylation factor-like protein 5C isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:3 → 86
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P068.1 GenPept UniProtKB/Swiss-Prot:Q6P068

    Gene LinkOut

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