Zfhx2 zinc finger homeobox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfhx2provided by MGI
Official Full Name: zinc finger homeobox 2provided by MGI
Primary source: MGI:MGI:2686934
See related: Ensembl:ENSMUSG00000040721 AllianceGenome:MGI:2686934
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZFH-5
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of sensory perception of pain. Acts upstream of or within adult behavior. Located in nucleus. Is expressed in several structures, including gut; male reproductive system; musculature; nervous system; and urinary system. Used to study Marsili syndrome. Human ortholog(s) of this gene implicated in Marsili syndrome. Orthologous to human ZFHX2 (zinc finger homeobox 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in cerebellum adult (RPKM 11.4), CNS E14 (RPKM 7.0) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.05 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55297722..55329875, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55060268..55092381, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homozygous Zfhx2-deficient mice showed several behavioral abnormalities, namely, hyperactivity, enhanced depression-like behaviors, and an aberrantly altered anxiety-like phenotype
Title: Behavioral abnormalities observed in Zfhx2-deficient mice.
Results report features of zfh-5 isolated from the mouse brain; in addition to the mRNA, the antisense strand of zfh-5 is also expressed in the developing brain, in a manner complementary to the expression of zfh-5 mRNA.
Title: Novel transcription factor zfh-5 is negatively regulated by its own antisense RNA in mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU049322 (e-PCR)
- UniSTS:145770

D1S3688 (e-PCR)
- UniSTS:474266

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger homeobox protein 2

Names: zinc finger homeodomain protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039198.1 → NP_001034287.1 zinc finger homeobox protein 2

Status: PROVISIONAL

Source sequence(s)

AB190186

Consensus CDS

CCDS27107.1

UniProtKB/Swiss-Prot

Q2MHN3, Q5DU04, Q80VJ9

Related

ENSMUSP00000045156.9, ENSMUST00000036328.9

Conserved Domains (7) summary

cd00086
Location:1852 → 1910

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

sd00017
Location:1187 → 1209

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:2443 → 2486

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00046
Location:2062 → 2114

Homeobox; Homeobox domain

pfam13909
Location:501 → 525

zf-H2C2_5; C2H2-type zinc-finger domain

cl26464
Location:2186 → 2300

Atrophin-1; Atrophin-1 family

cl27820
Location:1818 → 1944

Abdominal-A; Homeobox protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

55297722..55329875 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316015.3 → XP_017171504.1 zinc finger homeobox protein 2 isoform X3

Conserved Domains (6) summary

PHA03247
Location:2156 → 2270

PHA03247; large tegument protein UL36; Provisional

COG5576
Location:1788 → 1914

COG5576; Homeodomain-containing transcription factor [Transcription]

sd00017
Location:1157 → 1179

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:2413 → 2456

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00046
Location:2032 → 2085

Homeobox; Homeobox domain

pfam13909
Location:501 → 525

zf-H2C2_5; C2H2-type zinc-finger domain
XM_030247796.2 → XP_030103656.1 zinc finger homeobox protein 2 isoform X2

Conserved Domains (6) summary

PHA03247
Location:2166 → 2280

PHA03247; large tegument protein UL36; Provisional

COG5576
Location:1798 → 1924

COG5576; Homeodomain-containing transcription factor [Transcription]

sd00017
Location:1167 → 1189

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:2423 → 2466

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00046
Location:2042 → 2095

Homeobox; Homeobox domain

pfam13909
Location:501 → 525

zf-H2C2_5; C2H2-type zinc-finger domain
XM_011245060.4 → XP_011243362.3 zinc finger homeobox protein 2 isoform X1

Conserved Domains (6) summary

PHA03247
Location:2196 → 2310

PHA03247; large tegument protein UL36; Provisional

COG5576
Location:1828 → 1954

COG5576; Homeodomain-containing transcription factor [Transcription]

sd00017
Location:1197 → 1219

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00020
Location:2453 → 2496

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00046
Location:2072 → 2125

Homeobox; Homeobox domain

pfam13909
Location:501 → 525

zf-H2C2_5; C2H2-type zinc-finger domain