Eif4e2 eukaryotic translation initiation factor 4E member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif4e2provided by MGI
Official Full Name: eukaryotic translation initiation factor 4E member 2provided by MGI
Primary source: MGI:MGI:1914440
See related: Ensembl:ENSMUSG00000026254 AllianceGenome:MGI:1914440
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eif4el3; D0H0S6743E; 2700069E09Rik
Summary: Predicted to enable RNA cap binding activity; translation initiation factor activity; and ubiquitin protein ligase binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in P-body. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including brain; early conceptus; intestine; lung; and oocyte. Orthologous to human EIF4E2 (eukaryotic translation initiation factor 4E family member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in testis adult (RPKM 12.5), placenta adult (RPKM 6.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 44.08 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87141633..87168210)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (87213911..87240488)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.
Title: Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP.
The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.
Title: The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.
microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.
Title: microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP.
DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with Eif4e2. In turn, this causes Eif4e2 recruitment to the mRNA cap, where it is known to compete with eIF4E.
Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
Data show that Prep1 and 4EHP co-localize in the cytosol of growing mouse oocytes, and that Prep1 binds the Hoxb4 3'UTR to inhibit its translation.[4EHP]
Title: Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Eif4e2 (e-PCR), detects polymorphism
- UniSTS:532885

AI036339 (e-PCR)
- UniSTS:163257

AV129531 (e-PCR)
- UniSTS:178431

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA cap binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translational initiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E type 2

Names: eIF-4E type 2; eIF4E type 2; eIF4E-2; eIF4E-like protein 4E-LP; eukaryotic translation initiation factor 4E like 3; mRNA cap-binding protein type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039169.1 → NP_001034258.1 eukaryotic translation initiation factor 4E type 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC102611, AK017221

Consensus CDS

CCDS15131.1

UniProtKB/TrEMBL

D3Z730, Q0P688

Related

ENSMUSP00000108857.4, ENSMUST00000113231.4

Conserved Domains (1) summary

pfam01652
Location:50 → 208

IF4E; Eukaryotic initiation factor 4E
NM_001039170.1 → NP_001034259.1 eukaryotic translation initiation factor 4E type 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC102611, AK032965

Consensus CDS

CCDS35652.1

UniProtKB/Swiss-Prot

O88503, Q3UCK2, Q8BMB3

UniProtKB/TrEMBL

Q3UUT0

Related

ENSMUSP00000108859.2, ENSMUST00000113233.8

Conserved Domains (1) summary

pfam01652
Location:55 → 213

IF4E; Eukaryotic initiation factor 4E
NM_001347083.1 → NP_001334012.1 eukaryotic translation initiation factor 4E type 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC102611

Consensus CDS

CCDS83571.1

UniProtKB/TrEMBL

D3Z729, Q3UUT0

Related

ENSMUSP00000108861.2, ENSMUST00000113235.8

Conserved Domains (1) summary

pfam01652
Location:55 → 213

IF4E; Eukaryotic initiation factor 4E
NM_023314.3 → NP_075803.2 eukaryotic translation initiation factor 4E type 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 3'-most exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC102611, AK032965, AK076067

Consensus CDS

CCDS15130.1

UniProtKB/TrEMBL

G3X9H1, Q9D334

Related

ENSMUSP00000075699.6, ENSMUST00000076362.12

Conserved Domains (1) summary

pfam01652
Location:55 → 213

IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

87141633..87168210

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165581.1 → XP_036021474.1 eukaryotic translation initiation factor 4E type 2 isoform X1

UniProtKB/TrEMBL

Q9D334

Conserved Domains (1) summary

pfam01652
Location:55 → 214

IF4E; Eukaryotic initiation factor 4E
XM_036165586.1 → XP_036021479.1 eukaryotic translation initiation factor 4E type 2 isoform X3

UniProtKB/TrEMBL

Q9D334

Conserved Domains (1) summary

pfam01652
Location:55 → 214

IF4E; Eukaryotic initiation factor 4E
XM_006529674.4 → XP_006529737.1 eukaryotic translation initiation factor 4E type 2 isoform X7

UniProtKB/TrEMBL

D3YUV9, Q80ZJ3

Related

ENSMUSP00000053403.8, ENSMUST00000050876.14

Conserved Domains (1) summary

pfam01652
Location:55 → 214

IF4E; Eukaryotic initiation factor 4E
XM_030254746.1 → XP_030110606.1 eukaryotic translation initiation factor 4E type 2 isoform X5

UniProtKB/TrEMBL

Q9D334

Conserved Domains (1) summary

pfam01652
Location:50 → 209

IF4E; Eukaryotic initiation factor 4E
XM_030254745.1 → XP_030110605.1 eukaryotic translation initiation factor 4E type 2 isoform X4

UniProtKB/TrEMBL

D3Z730

Conserved Domains (1) summary

pfam01652
Location:50 → 209

IF4E; Eukaryotic initiation factor 4E
XM_036165583.1 → XP_036021476.1 eukaryotic translation initiation factor 4E type 2 isoform X2

UniProtKB/TrEMBL

Q9D334

Conserved Domains (1) summary

pfam01652
Location:50 → 209

IF4E; Eukaryotic initiation factor 4E
XM_036165589.1 → XP_036021482.1 eukaryotic translation initiation factor 4E type 2 isoform X6

UniProtKB/TrEMBL

D3Z730

Conserved Domains (1) summary

pfam01652
Location:50 → 209

IF4E; Eukaryotic initiation factor 4E