ZWINT ZW10 interacting kinetochore protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZWINTprovided by HGNC
Official Full Name: ZW10 interacting kinetochore proteinprovided by HGNC
Primary source: HGNC:HGNC:13195
See related: Ensembl:ENSG00000122952 MIM:609177; AllianceGenome:HGNC:13195
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIP30; ZWINT1; KNTC2AP; HZwint-1
Summary: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in bone marrow (RPKM 17.2), testis (RPKM 16.4) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q21.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (56357227..56361273, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (57207567..57211612, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (58116988..58121034, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.
Title: ZWINT promotes the proliferation, migration, and invasion of cervical cancer cells by regulating the p53/p21 signaling pathway.
Genome-wide association analysis of cognitive function in Danish long-lived individuals.
Title: Genome-wide association analysis of cognitive function in Danish long-lived individuals.
Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.
Title: Anaphase-promoting complex/cyclosome-Cdc-20 promotes Zwint-1 degradation.
ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.
Title: ZWINT: A potential therapeutic biomarker in patients with glioblastoma correlates with cell proliferation and invasion.
upregulated in prostate cancer tissues
Title: Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis.
results suggested ZWINT as a potential gene associated with lung cancer cell proliferation
Title: ZWINT is the next potential target for lung cancer therapy.
ZW10 interactor was frequently decreased in hepatocellular carcinoma.
Title: Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery.
Our results provide the first evidence that Zwint-1 is required to correct erroneous kinetochore-microtubule attachment and regulate spindle checkpoint function during meiosis.
Title: Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.
the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation
Title: Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.
These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase
Title: Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of localization in cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
involved_in homologous chromosome orientation in meiotic metaphase I	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid segregation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of meiosis I spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Knl1/Spc105 complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
is_active_in nuclear body	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
part_of outer kinetochore	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: outer kinetochore KNL1 complex subunit ZWINT

Names: SNAP25 interacting protein of 30 kDa; ZW10 interactor, kinetochore protein; human ZW10 interacting protein-1; zwint-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033939.1 RefSeqGene

Range

5015..9047

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001005413.1 → NP_001005413.1 outer kinetochore KNL1 complex subunit ZWINT isoform b

See identical proteins and their annotated locations for NP_001005413.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

BC016357, BC020979, BG615304, BM724168

Consensus CDS

CCDS31205.1

UniProtKB/TrEMBL

B4DP12

Related

ENSP00000354921.6, ENST00000361148.6

Conserved Domains (1) summary

pfam15556
Location:29 → 230

Zwint; ZW10 interactor
NM_007057.4 → NP_008988.2 outer kinetochore KNL1 complex subunit ZWINT isoform a

See identical proteins and their annotated locations for NP_008988.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the predominant transcript and differs in the 3' UTR compared to variant 2. Variants 1 and 2 both encode isoform a.

Source sequence(s)

AC010996, BC000411, BC016357, BC020979, BG615304

Consensus CDS

CCDS7249.1

UniProtKB/Swiss-Prot

A6NNV6, O95229, Q0D2I3, Q9BWD0

UniProtKB/TrEMBL

B4DP12

Related

ENSP00000363055.3, ENST00000373944.8

Conserved Domains (1) summary

pfam15556
Location:29 → 277

Zwint; ZW10 interactor
NM_032997.3 → NP_127490.1 outer kinetochore KNL1 complex subunit ZWINT isoform a

See identical proteins and their annotated locations for NP_127490.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.

Source sequence(s)

BC000411, BC016357, BC020979, BG615304

Consensus CDS

CCDS7249.1

UniProtKB/Swiss-Prot

A6NNV6, O95229, Q0D2I3, Q9BWD0

UniProtKB/TrEMBL

B4DP12

Related

ENSP00000378801.1, ENST00000395405.5

Conserved Domains (1) summary

pfam15556
Location:29 → 277

Zwint; ZW10 interactor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

56357227..56361273 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

RNA

XR_428692.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

57207567..57211612 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

RNA

XR_008488158.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001005414.1: Suppressed sequence

Description

NM_001005414.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.