MAFG MAF bZIP transcription factor G [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAFGprovided by HGNC
Official Full Name: MAF bZIP transcription factor Gprovided by HGNC
Primary source: HGNC:HGNC:6781
See related: Ensembl:ENSG00000197063 MIM:602020; AllianceGenome:HGNC:6781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hMAF
Summary: Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
Expression: Ubiquitous expression in bone marrow (RPKM 12.5), brain (RPKM 8.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (81918270..81931244, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (82785430..82798403, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (79876146..79885611, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
Title: MAFG-AS1/MAFG positive feedback loop contributes to cisplatin resistance in bladder urothelial carcinoma through antagonistic ferroptosis.
LncRNA MAFG-AS1 Upregulates Polo-Like Kinase-1 by Sponging miR-505 to Promote Gastric Adenocarcinoma Cell Proliferation.
Title: LncRNA MAFG-AS1 Upregulates Polo-Like Kinase-1 by Sponging miR-505 to Promote Gastric Adenocarcinoma Cell Proliferation.
The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation.
Title: The small protein MafG plays a critical role in MC3T3-E1 cell apoptosis induced by simulated microgravity and radiation.
High-expression of LncRNA MAFG-AS1 is associated with the prognostic of patients with colorectal cancer.
Title: High-expression of LncRNA MAFG-AS1 is associated with the prognostic of patients with colorectal cancer.
MAFG-lncRNA controlled hepatic glucose metabolism in health and metabolic disease.
Title: A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.
identification of astrocytes in EAE and multiple sclerosis that were characterized by decreased expression of NRF2 and increased expression of MAFG, which cooperates with MAT2alpha to promote DNA methylation and represses antioxidant and anti-inflammatory transcriptional programs
Title: MAFG-driven astrocytes promote CNS inflammation.
LncRNA MAFG-AS1 boosts the proliferation of lung adenocarcinoma cells via regulating miR-744-5p/MAFG axis
Title: LncRNA MAFG-AS1 boosts the proliferation of lung adenocarcinoma cells via regulating miR-744-5p/MAFG axis.
Over-expression of MAFG-AS1 significantly decreased the level of miR-339-5p in NSCLC cell. Moreover, the matrix metalloproteinase 15 (MMP15) was identified to be a target of miR-339-5p.
Title: LncRNA MAFG-AS1 facilitates the migration and invasion of NSCLC cell via sponging miR-339-5p from MMP15.
musculoaponeurotic fibrosarcoma oncogene family, protein G (MAFG) modulates the redox response and confers cell protection against free radicals generated after platinum administration thus also being a promising therapeutic target in non-small-cell lung cancer drug therapy
Title: MAFG is a potential therapeutic target to restore chemosensitivity in cisplatin-resistant cancer cells by increasing reactive oxygen species.
Expression of MAFG increases in cells and tissues with cholestasis, as well as in human cholangiocarcinoma and hepatocellular carcinoma specimens; high expression levels correlate with tumor progression and reduced survival time.
Title: Mechanisms of MAFG Dysregulation in Cholestatic Liver Injury and Development of Liver Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MAFG__7350 (e-PCR)
- UniSTS:467758

D17S2144 (e-PCR)
- UniSTS:24747

D17S1450E (e-PCR)
- UniSTS:150490

RH78412 (e-PCR)
- UniSTS:69620

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adult behavior	IEA Inferred from Electronic Annotation more info
involved_in in utero embryonic development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of epidermal cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: transcription factor MafG

Names: basic leucine zipper transcription factor MafG; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002359.4 → NP_002350.1 transcription factor MafG

See identical proteins and their annotated locations for NP_002350.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AA775797, AC145207, BC103722, DR156847

Consensus CDS

CCDS11793.1

UniProtKB/Swiss-Prot

O15525

Related

ENSP00000350369.4, ENST00000357736.9

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
NM_032711.4 → NP_116100.2 transcription factor MafG

See identical proteins and their annotated locations for NP_116100.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AA775797, AC145207, BC012327, BC103722

Consensus CDS

CCDS11793.1

UniProtKB/Swiss-Prot

O15525

Related

ENSP00000376173.3, ENST00000392366.7

Conserved Domains (1) summary

cd14717
Location:46 → 115

bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

81918270..81931244 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047436070.1 → XP_047292026.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525
XM_047436071.1 → XP_047292027.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525
XM_047436072.1 → XP_047292028.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525
XM_047436068.1 → XP_047292024.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525
XM_047436069.1 → XP_047292025.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

82785430..82798403 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054316128.1 → XP_054172103.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525
XM_054316129.1 → XP_054172104.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525
XM_054316130.1 → XP_054172105.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525
XM_054316126.1 → XP_054172101.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525
XM_054316127.1 → XP_054172102.1 transcription factor MafG isoform X1

UniProtKB/Swiss-Prot

O15525