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    CXCR6 C-X-C motif chemokine receptor 6 [ Homo sapiens (human) ]

    Gene ID: 10663, updated on 10-Dec-2024

    Summary

    Official Symbol
    CXCR6provided by HGNC
    Official Full Name
    C-X-C motif chemokine receptor 6provided by HGNC
    Primary source
    HGNC:HGNC:16647
    See related
    Ensembl:ENSG00000172215 MIM:605163; AllianceGenome:HGNC:16647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BONZO; CD186; CDw186; STRL33; TYMSTR
    Summary
    The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine receptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020]
    Expression
    Broad expression in lymph node (RPKM 5.9), spleen (RPKM 4.9) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CXCR6 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (45940915..45948351)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (45956798..45964234)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45982407..45989843)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leucine zipper transcription factor like 1 Neighboring gene CCR9 promoter region Neighboring gene succinate dehydrogenase complex subunit D pseudogene 4 Neighboring gene C-C motif chemokine receptor 9 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:45956761-45957960 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:45979037-45980236 Neighboring gene FYVE and coiled-coil domain autophagy adaptor 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:45989039-45989208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:46009167-46009806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:46009807-46010446 Neighboring gene Sharpr-MPRA regulatory region 2695 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46029541-46030041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46034569-46035069 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46037115-46037614 Neighboring gene uncharacterized LOC105377063 Neighboring gene nuclear receptor binding factor 2 pseudogene 2 Neighboring gene X-C motif chemokine receptor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed
    env Some HIV-1 isolates are able to use CCR5/Bonzo as HIV-1 gp120 coreceptors for entry into cells PubMed
    env Coexpression of DC-SIGN enables some HIV-1 isolates to use alternate HIV-1 gp120 coreceptors like STRL33 to infect cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables C-C chemokine binding  
    enables C-C chemokine receptor activity  
    enables C-X-C chemokine receptor activity  
    enables G protein-coupled receptor activity PubMed 
    enables coreceptor activity  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway PubMed 
    involved_in calcium-mediated signaling  
    involved_in cell chemotaxis  
    involved_in chemokine-mediated signaling pathway  
    involved_in immune response  
    involved_in inflammatory response  
    involved_in positive regulation of cytosolic calcium ion concentration  
    involved_in viral genome replication PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    C-X-C chemokine receptor type 6
    Names
    G protein-coupled receptor
    G-protein coupled receptor STRL33
    G-protein coupled receptor bonzo
    chemokine (C-X-C motif) receptor 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386435.1 → NP_001373364.1  C-X-C chemokine receptor type 6

      Status: REVIEWED

      Source sequence(s)
      AC099782
      Consensus CDS
      CCDS2735.1
      UniProtKB/Swiss-Prot
      O00574, O00575, Q9HCA5
      UniProtKB/TrEMBL
      A0N0N3
      Related
      ENSP00000396886.1, ENST00000457814.1
      Conserved Domains (1) summary
      cd15173
      Location:32 → 299
      7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001386436.1 → NP_001373365.1  C-X-C chemokine receptor type 6

      Status: REVIEWED

      Source sequence(s)
      AC099782
      Consensus CDS
      CCDS2735.1
      UniProtKB/Swiss-Prot
      O00574, O00575, Q9HCA5
      UniProtKB/TrEMBL
      A0N0N3
      Conserved Domains (1) summary
      cd15173
      Location:32 → 299
      7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001386437.1 → NP_001373366.1  C-X-C chemokine receptor type 6

      Status: REVIEWED

      Source sequence(s)
      AC099782
      Consensus CDS
      CCDS2735.1
      UniProtKB/Swiss-Prot
      O00574, O00575, Q9HCA5
      UniProtKB/TrEMBL
      A0N0N3
      Related
      ENSP00000396218.1, ENST00000438735.1
      Conserved Domains (1) summary
      cd15173
      Location:32 → 299
      7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_006564.2 → NP_006555.1  C-X-C chemokine receptor type 6

      See identical proteins and their annotated locations for NP_006555.1

      Status: REVIEWED

      Source sequence(s)
      AC099782, Y13248
      Consensus CDS
      CCDS2735.1
      UniProtKB/Swiss-Prot
      O00574, O00575, Q9HCA5
      UniProtKB/TrEMBL
      A0N0N3
      Related
      ENSP00000304414.4, ENST00000304552.5
      Conserved Domains (1) summary
      cd15173
      Location:32 → 299
      7tmA_CXCR6; CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      45940915..45948351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      45956798..45964234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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