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    CPEB3 cytoplasmic polyadenylation element binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 22849, updated on 10-Dec-2024

    Summary

    Official Symbol
    CPEB3provided by HGNC
    Official Full Name
    cytoplasmic polyadenylation element binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:21746
    See related
    Ensembl:ENSG00000107864 MIM:610606; AllianceGenome:HGNC:21746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables mRNA 3'-UTR binding activity and translation factor activity, RNA binding. Involved in cellular response to amino acid stimulus and regulation of gene expression. Located in several cellular components, including cytosol; midbody; and nucleoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in brain (RPKM 4.8), liver (RPKM 4.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CPEB3 in Genome Data Viewer
    Location:
    10q23.32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (92046692..92291233, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (92929099..93173600, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93806449..94050835, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:93682269-93682802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3766 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:93805711-93806387 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:93816841-93817342 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:93835428-93836089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3767 Neighboring gene uncharacterized LOC107984254 Neighboring gene SDHC pseudogene 2 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2614 Neighboring gene uncharacterized LOC124902483 Neighboring gene NHP2 ribonucleoprotein pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2615 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:94051286-94051864 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94065899-94066610 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94066611-94067322 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:94072769-94073270 Neighboring gene membrane associated ring-CH-type finger 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:94107981-94108480 Neighboring gene NANOG hESC enhancer GRCh37_chr10:94110043-94110561 Neighboring gene RNY3 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2616 Neighboring gene MARK2 pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA binding PubMed 
    enables RNA stem-loop binding  
    enables mRNA 3'-UTR AU-rich region binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding PubMed 
    enables mRNA 3'-UTR binding  
    enables mRNA regulatory element binding translation repressor activity  
    enables mRNA regulatory element binding translation repressor activity  
    enables protein binding PubMed 
    enables ribosome binding  
    enables translation factor activity, RNA binding  
    enables translation factor activity, RNA binding PubMed 
    enables translation factor activity, RNA binding  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization PubMed 
    involved_in cellular response to amino acid stimulus PubMed 
    involved_in cellular response to amino acid stimulus  
    involved_in long-term memory  
    involved_in negative regulation of cytoplasmic translation  
    involved_in negative regulation of cytoplasmic translational elongation  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of translation PubMed 
    involved_in positive regulation of dendritic spine development  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening PubMed 
    involved_in positive regulation of translation  
    involved_in regulation of dendritic spine development  
    involved_in regulation of synaptic plasticity  
    involved_in translation  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex PubMed 
    located_in apical dendrite  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in dendrite  
    located_in midbody  
    is_active_in neuron projection  
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in plasma membrane  
    located_in postsynaptic density  
    is_active_in synapse  
    located_in synapse  

    General protein information

    Preferred Names
    cytoplasmic polyadenylation element-binding protein 3
    Names
    CPE-BP3
    CPE-binding protein 3
    hCPEB-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001178137.2 → NP_001171608.1  cytoplasmic polyadenylation element-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001171608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AB023157, AL365398, BC036444, BU785463, DA697430
      Consensus CDS
      CCDS53553.1
      UniProtKB/TrEMBL
      Q5QP71
      Related
      ENSP00000398310.2, ENST00000412050.8
      Conserved Domains (4) summary
      COG0724
      Location:423 → 589
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:427 → 518
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:535 → 615
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:610 → 671
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    2. NM_014912.5 → NP_055727.3  cytoplasmic polyadenylation element-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_055727.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AB023157, AK127060, AL365398, BC036444, BU785463
      Consensus CDS
      CCDS31246.1
      UniProtKB/Swiss-Prot
      Q5T389, Q8NE35, Q9NQJ7, Q9Y2E9
      Related
      ENSP00000265997.4, ENST00000265997.5
      Conserved Domains (4) summary
      COG0724
      Location:437 → 603
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:441 → 532
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:549 → 629
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:624 → 685
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      92046692..92291233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424810.1 → XP_047280766.1  cytoplasmic polyadenylation element-binding protein 3 isoform X2

    2. XM_024447895.2 → XP_024303663.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

      Conserved Domains (3) summary
      pfam16366
      Location:641 → 702
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      cd12724
      Location:458 → 549
      RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:566 → 646
      RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    3. XM_011539517.3 → XP_011537819.1  cytoplasmic polyadenylation element-binding protein 3 isoform X5

      Conserved Domains (4) summary
      COG0724
      Location:404 → 570
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:408 → 499
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:516 → 596
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:591 → 652
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    4. XM_011539520.3 → XP_011537822.1  cytoplasmic polyadenylation element-binding protein 3 isoform X9

      Conserved Domains (3) summary
      cd12726
      Location:449 → 529
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:524 → 585
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      cl17169
      Location:386 → 432
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_005269630.5 → XP_005269687.1  cytoplasmic polyadenylation element-binding protein 3 isoform X4

      See identical proteins and their annotated locations for XP_005269687.1

      UniProtKB/TrEMBL
      Q5QP71
      Conserved Domains (4) summary
      COG0724
      Location:423 → 589
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:427 → 518
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:535 → 615
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:610 → 671
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    6. XM_011539515.3 → XP_011537817.1  cytoplasmic polyadenylation element-binding protein 3 isoform X3

      Conserved Domains (4) summary
      COG0724
      Location:431 → 597
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:435 → 526
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:543 → 623
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:618 → 679
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    7. XM_011539519.3 → XP_011537821.1  cytoplasmic polyadenylation element-binding protein 3 isoform X8

      Conserved Domains (3) summary
      cd12726
      Location:472 → 552
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:547 → 608
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      cl17169
      Location:409 → 455
      RRM_SF; RNA recognition motif (RRM) superfamily
    8. XM_011539514.3 → XP_011537816.1  cytoplasmic polyadenylation element-binding protein 3 isoform X2

      Conserved Domains (4) summary
      COG0724
      Location:446 → 612
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:450 → 541
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:558 → 638
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      pfam16366
      Location:633 → 694
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
    9. XM_006717715.4 → XP_006717778.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006717778.1

      Conserved Domains (3) summary
      pfam16366
      Location:641 → 702
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      cd12724
      Location:458 → 549
      RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:566 → 646
      RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    10. XM_047424814.1 → XP_047280770.1  cytoplasmic polyadenylation element-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      Q5QP71
    11. XM_047424812.1 → XP_047280768.1  cytoplasmic polyadenylation element-binding protein 3 isoform X3

    12. XM_047424809.1 → XP_047280765.1  cytoplasmic polyadenylation element-binding protein 3 isoform X2

    13. XM_047424807.1 → XP_047280763.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    14. XM_024447894.2 → XP_024303662.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

      Conserved Domains (3) summary
      pfam16366
      Location:641 → 702
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      cd12724
      Location:458 → 549
      RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:566 → 646
      RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    15. XM_047424813.1 → XP_047280769.1  cytoplasmic polyadenylation element-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      Q5QP71
    16. XM_047424818.1 → XP_047280774.1  cytoplasmic polyadenylation element-binding protein 3 isoform X8

    17. XM_047424808.1 → XP_047280764.1  cytoplasmic polyadenylation element-binding protein 3 isoform X2

    18. XM_024447893.2 → XP_024303661.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

      Conserved Domains (3) summary
      pfam16366
      Location:641 → 702
      CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
      cd12724
      Location:458 → 549
      RRM1_CPEB2_like; RNA recognition motif 1 (RRM1) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:566 → 646
      RRM2_CPEB2_like; RNA recognition motif 2 (RRM2) found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    19. XM_017015927.2 → XP_016871416.1  cytoplasmic polyadenylation element-binding protein 3 isoform X12

      UniProtKB/TrEMBL
      A0A590UJI5
    20. XM_047424815.1 → XP_047280771.1  cytoplasmic polyadenylation element-binding protein 3 isoform X7

    21. XM_011539518.3 → XP_011537820.1  cytoplasmic polyadenylation element-binding protein 3 isoform X6

      Conserved Domains (3) summary
      COG0724
      Location:454 → 620
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12724
      Location:458 → 549
      RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
      cd12726
      Location:566 → 640
      RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    22. XM_047424816.1 → XP_047280772.1  cytoplasmic polyadenylation element-binding protein 3 isoform X7

    23. XM_047424820.1 → XP_047280776.1  cytoplasmic polyadenylation element-binding protein 3 isoform X11

    24. XM_047424819.1 → XP_047280775.1  cytoplasmic polyadenylation element-binding protein 3 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      92929099..93173600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365181.1 → XP_054221156.1  cytoplasmic polyadenylation element-binding protein 3 isoform X2

    2. XM_054365178.1 → XP_054221153.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    3. XM_054365185.1 → XP_054221160.1  cytoplasmic polyadenylation element-binding protein 3 isoform X5

    4. XM_054365191.1 → XP_054221166.1  cytoplasmic polyadenylation element-binding protein 3 isoform X9

    5. XM_054365183.1 → XP_054221158.1  cytoplasmic polyadenylation element-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      Q5QP71
    6. XM_054365182.1 → XP_054221157.1  cytoplasmic polyadenylation element-binding protein 3 isoform X3

    7. XM_054365189.1 → XP_054221164.1  cytoplasmic polyadenylation element-binding protein 3 isoform X8

    8. XM_054365179.1 → XP_054221154.1  cytoplasmic polyadenylation element-binding protein 3 isoform X2

    9. XM_054365175.1 → XP_054221150.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    10. XM_054365177.1 → XP_054221152.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    11. XM_054365184.1 → XP_054221159.1  cytoplasmic polyadenylation element-binding protein 3 isoform X4

      UniProtKB/TrEMBL
      Q5QP71
    12. XM_054365190.1 → XP_054221165.1  cytoplasmic polyadenylation element-binding protein 3 isoform X8

    13. XM_054365180.1 → XP_054221155.1  cytoplasmic polyadenylation element-binding protein 3 isoform X2

    14. XM_054365176.1 → XP_054221151.1  cytoplasmic polyadenylation element-binding protein 3 isoform X1

    15. XM_054365194.1 → XP_054221169.1  cytoplasmic polyadenylation element-binding protein 3 isoform X12

      UniProtKB/TrEMBL
      A0A590UJI5
    16. XM_054365187.1 → XP_054221162.1  cytoplasmic polyadenylation element-binding protein 3 isoform X7

    17. XM_054365186.1 → XP_054221161.1  cytoplasmic polyadenylation element-binding protein 3 isoform X6

    18. XM_054365188.1 → XP_054221163.1  cytoplasmic polyadenylation element-binding protein 3 isoform X7

    19. XM_054365193.1 → XP_054221168.1  cytoplasmic polyadenylation element-binding protein 3 isoform X11

    20. XM_054365192.1 → XP_054221167.1  cytoplasmic polyadenylation element-binding protein 3 isoform X10

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