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    FAM230B family with sequence similarity 230 member B [ Homo sapiens (human) ]

    Gene ID: 642633, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FAM230Bprovided by HGNC
    Official Full Name
    family with sequence similarity 230 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:32943
    See related
    Ensembl:ENSG00000215498 AllianceGenome:HGNC:32943
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 11.2) See more
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    Genomic context

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    See FAM230B in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (21167865..21192161)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (21577645..21602006)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21522154..21546450)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene BCR pseudogene 2 Neighboring gene POM121 transmembrane nucleoporin like 7 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:21483022-21483890 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:21498806-21499306 Neighboring gene E2F transcription factor 6 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:21507745-21507931 Neighboring gene MPRA-validated peak4462 silencer Neighboring gene MPRA-validated peak4464 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21555249-21555931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21555932-21556613 Neighboring gene family with sequence similarity 247 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21569798-21570298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:21570299-21570799 Neighboring gene gamma-glutamyltransferase 2, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:21585968-21586526 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:21609011-21609708 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:21609709-21610404 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:21610405-21611102 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:21613263-21613765

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Long non-coding RNA FAM230B is a novel prognostic and diagnostic biomarker for lung adenocarcinoma. Cao Y, et al. Bioengineered, 2022 Mar. PMID 35287554, Free PMC Article
    2. Analysis of the subcellular location of FAM230B and its interaction with premature miR-302b in osteosarcoma. Cheng S, et al. J Bone Miner Metab, 2022 Jul. PMID 35639175
    3. The Subcellular Localization of IncRNA FAM230B in Osteosarcoma and Its Interaction with Early miR-203. Song X, et al. Crit Rev Eukaryot Gene Expr, 2022. PMID 35377981
    4. METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer. Cui Y, et al. Biochim Biophys Acta Gen Subj, 2024 Nov. PMID 39278369
    5. Formation of a Family of Long Intergenic Noncoding RNA Genes with an Embedded Translocation Breakpoint Motif in Human Chromosomal Low Copy Repeats of 22q11.2-Some Surprises and Questions. Delihas N. Noncoding RNA, 2018 Jul 20. PMID 30036931, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer.
      Title: METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer.
    2. Long non-coding RNA FAM230B is a novel prognostic and diagnostic biomarker for lung adenocarcinoma.
      Title: Long non-coding RNA FAM230B is a novel prognostic and diagnostic biomarker for lung adenocarcinoma.
    3. Analysis of the subcellular location of FAM230B and its interaction with premature miR-302b in osteosarcoma.
      Title: Analysis of the subcellular location of FAM230B and its interaction with premature miR-302b in osteosarcoma.
    4. The Subcellular Localization of IncRNA FAM230B in Osteosarcoma and Its Interaction with Early miR-203.
      Title: The Subcellular Localization of IncRNA FAM230B in Osteosarcoma and Its Interaction with Early miR-203.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • family with sequence similarity 230 member B (non-protein coding)

    Clone Names

    • FLJ46366

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_165621.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AP000550
      Related
      ENST00000451257.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      21167865..21192161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      21577645..21602006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201565.1: Suppressed sequence

      Description
      NM_201565.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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