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    RBM12B RNA binding motif protein 12B [ Homo sapiens (human) ]

    Gene ID: 389677, updated on 10-Dec-2024

    Summary

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    Official Symbol
    RBM12Bprovided by HGNC
    Official Full Name
    RNA binding motif protein 12Bprovided by HGNC
    Primary source
    HGNC:HGNC:32310
    See related
    Ensembl:ENSG00000183808 AllianceGenome:HGNC:32310
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MGC:33837
    Summary
    Enables RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 5.9), ovary (RPKM 4.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RBM12B in Genome Data Viewer
    Location:
    8q22.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (93728155..93741009, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (94853161..94866033, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (94740383..94753237, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CIBAR1 divergent transcript Neighboring gene uncharacterized LOC105375641 Neighboring gene zinc finger protein 317 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27618 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:94712406-94713030 Neighboring gene CBY1 interacting BAR domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27619 Neighboring gene RBM12B antisense RNA 1 Neighboring gene RBM12B divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:94791793-94792322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:94792323-94792851 Neighboring gene transmembrane protein 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CEP192 interacts physically and functionally with the K63-deubiquitinase CYLD to promote mitotic spindle assembly. Gomez-Ferreria MA, et al. Cell Cycle, 2012 Oct 1. PMID 22895009, Free PMC Article
    2. The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Franke FC, et al. Cell Mol Gastroenterol Hepatol, 2019. PMID 30480076, Free PMC Article
    3. USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells. van den Berk P, et al. Cell Rep, 2020 Dec 29. PMID 33378683, Free PMC Article
    4. A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. Sohail M, et al. NAR Cancer, 2021 Jun. PMID 34316707, Free PMC Article
    5. Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase. Lenihan JA, et al. PLoS One, 2017. PMID 29121065, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 12B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377960.1 → NP_001364889.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000429807.2, ENST00000520560.6
      Conserved Domains (7) summary
      PTZ00121
      Location:449 → 680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689 → 915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284 → 363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:2 → 80
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153 → 238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400 → 475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:925 → 1001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    2. NM_001377961.1 → NP_001364890.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Conserved Domains (7) summary
      PTZ00121
      Location:449 → 680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689 → 915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284 → 363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:2 → 80
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153 → 238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400 → 475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:925 → 1001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    3. NM_001377962.1 → NP_001364891.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Conserved Domains (7) summary
      PTZ00121
      Location:449 → 680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689 → 915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284 → 363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:2 → 80
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153 → 238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400 → 475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:925 → 1001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    4. NM_001377963.1 → NP_001364892.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000430474.2, ENST00000519109.6
      Conserved Domains (7) summary
      PTZ00121
      Location:449 → 680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689 → 915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284 → 363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:2 → 80
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153 → 238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400 → 475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:925 → 1001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    5. NM_001377964.1 → NP_001364893.1  RNA-binding protein 12B

      Status: VALIDATED

      Source sequence(s)
      AC010834
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Conserved Domains (7) summary
      PTZ00121
      Location:449 → 680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689 → 915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284 → 363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:2 → 80
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153 → 238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400 → 475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:925 → 1001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    6. NM_203390.4 → NP_976324.2  RNA-binding protein 12B

      See identical proteins and their annotated locations for NP_976324.2

      Status: VALIDATED

      Source sequence(s)
      AC010834, BC039260
      Consensus CDS
      CCDS43755.1
      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000382239.2, ENST00000399300.7
      Conserved Domains (7) summary
      PTZ00121
      Location:449 → 680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689 → 915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284 → 363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:2 → 80
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153 → 238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400 → 475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:925 → 1001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      93728155..93741009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517029.3 → XP_011515331.1  RNA-binding protein 12B isoform X1

      See identical proteins and their annotated locations for XP_011515331.1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000428269.2, ENST00000518597.2
      Conserved Domains (7) summary
      PTZ00121
      Location:449 → 680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689 → 915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284 → 363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:2 → 80
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153 → 238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400 → 475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:925 → 1001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    2. XM_047421772.1 → XP_047277728.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    3. XM_017013408.3 → XP_016868897.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
      Related
      ENSP00000427729.2, ENST00000517700.6
      Conserved Domains (7) summary
      PTZ00121
      Location:449 → 680
      PTZ00121; MAEBL; Provisional
      PHA03321
      Location:689 → 915
      PHA03321; tegument protein VP11/12; Provisional
      cd12513
      Location:284 → 363
      RRM3_RBM12B; RNA recognition motif 3 (RRM3) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12744
      Location:2 → 80
      RRM1_RBM12B; RNA recognition motif 1 (RRM1) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12746
      Location:153 → 238
      RRM2_RBM12B; RNA recognition motif 2 (RRM2) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12748
      Location:400 → 475
      RRM4_RBM12B; RNA recognition motif 4 (RRM4) found in RNA-binding protein 12B (RBM12B) and similar proteins
      cd12750
      Location:925 → 1001
      RRM5_RBM12B; RNA recognition motif 5 (RRM5) found in RNA-binding protein 12B (RBM12B) and similar proteins

    4. XM_047421773.1 → XP_047277729.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    5. XM_047421771.1 → XP_047277727.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    6. XM_047421776.1 → XP_047277732.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    7. XM_047421774.1 → XP_047277730.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    8. XM_047421770.1 → XP_047277726.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    9. XM_047421775.1 → XP_047277731.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      94853161..94866033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360468.1 → XP_054216443.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    2. XM_054360469.1 → XP_054216444.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    3. XM_054360464.1 → XP_054216439.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    4. XM_054360463.1 → XP_054216438.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    5. XM_054360467.1 → XP_054216442.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    6. XM_054360465.1 → XP_054216440.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    7. XM_054360462.1 → XP_054216437.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1

    8. XM_054360466.1 → XP_054216441.1  RNA-binding protein 12B isoform X1

      UniProtKB/Swiss-Prot
      A8MYB5, Q8IXT5
      UniProtKB/TrEMBL
      B9ZVT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IXT5.2 GenPept UniProtKB/Swiss-Prot:Q8IXT5

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