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    ELK3 ETS transcription factor ELK3 [ Homo sapiens (human) ]

    Gene ID: 2004, updated on 9-Dec-2024

    Summary

    Official Symbol
    ELK3provided by HGNC
    Official Full Name
    ETS transcription factor ELK3provided by HGNC
    Primary source
    HGNC:HGNC:3325
    See related
    Ensembl:ENSG00000111145 MIM:600247; AllianceGenome:HGNC:3325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERP; NET; SAP2; SAP-2
    Summary
    This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Annotation information
    Note: NET is an alias on both SLC6A2 (Gene ID: 6530, "norepinephrine transporter") and ELK3 (Gene ID: 2004). [01 Jun 2018]
    Expression
    Ubiquitous expression in spleen (RPKM 23.7), endometrium (RPKM 22.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ELK3 in Genome Data Viewer
    Location:
    12q23.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (96194375..96269824)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (96168506..96244027)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96588153..96663602)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369923 Neighboring gene RNA, 7SL, cytoplasmic 88, pseudogene Neighboring gene Sharpr-MPRA regulatory region 6189 Neighboring gene long intergenic non-protein coding RNA 2452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4741 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96603880-96604402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6826 Neighboring gene uncharacterized LOC124902991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96628784-96629768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96631810-96632310 Neighboring gene cyclin dependent kinase 17 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709352-96709984 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96709985-96710615 Neighboring gene RNA, U4 small nuclear 24, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6830 Neighboring gene RN7SK pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS domain-containing protein Elk-3
    Names
    ELK3, ETS transcription factor
    ELK3, ETS-domain protein (SRF accessory protein 2)
    ETS-related protein ERP
    ETS-related protein NET
    SRF accessory protein 2
    serum response factor accessory protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303511.2NP_001290440.1  ETS domain-containing protein Elk-3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks several exon in the 5' UTR and coding region and uses an alternate 5' most exon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC008149, AL705041, AW575797
    2. NM_001413760.1NP_001400689.1  ETS domain-containing protein Elk-3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008149
      UniProtKB/Swiss-Prot
      B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17
    3. NM_001413761.1NP_001400690.1  ETS domain-containing protein Elk-3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC008149
      UniProtKB/Swiss-Prot
      B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17
    4. NM_001413762.1NP_001400691.1  ETS domain-containing protein Elk-3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC008149
    5. NM_001413763.1NP_001400692.1  ETS domain-containing protein Elk-3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC008149
    6. NM_001413764.1NP_001400693.1  ETS domain-containing protein Elk-3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC008149
    7. NM_001413765.1NP_001400694.1  ETS domain-containing protein Elk-3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC008149
    8. NM_005230.4NP_005221.2  ETS domain-containing protein Elk-3 isoform 1

      See identical proteins and their annotated locations for NP_005221.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC008149, AK312694, AW575797, DA754301
      Consensus CDS
      CCDS9060.1
      UniProtKB/Swiss-Prot
      B2R6S6, P41970, Q6FG57, Q6GU29, Q9UD17
      Related
      ENSP00000228741.3, ENST00000228741.8
      Conserved Domains (1) summary
      smart00413
      Location:1988
      ETS; erythroblast transformation specific domain

    RNA

    1. NR_182212.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008149
    2. NR_182213.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008149
    3. NR_182214.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008149
    4. NR_182215.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008149

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      96194375..96269824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      96168506..96244027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)