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    CRIP2 cysteine rich protein 2 [ Homo sapiens (human) ]

    Gene ID: 1397, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CRIP2provided by HGNC
    Official Full Name
    cysteine rich protein 2provided by HGNC
    Primary source
    HGNC:HGNC:2361
    See related
    Ensembl:ENSG00000182809 MIM:601183; AllianceGenome:HGNC:2361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRIP; CRP2; ESP1
    Summary
    This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
    Expression
    Broad expression in heart (RPKM 55.7), lung (RPKM 26.3) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CRIP2 in Genome Data Viewer
    Location:
    14q32.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (105472945..105480170)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (99720088..99729539)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105939282..105946507)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105884361-105885030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105887709-105888376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105888377-105889046 Neighboring gene MTA1 divergent transcript Neighboring gene metastasis associated 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105903142-105903739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:105903740-105904336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105930591-105931113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105931114-105931635 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105937181-105938044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105939600-105940132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6242 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6243 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105947154-105947875 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:105954409-105954980 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6250 Neighboring gene hESC enhancers GRCh37_chr14:105956919-105957662 and GRCh37_chr14:105957663-105958406 Neighboring gene cysteine rich protein 1 Neighboring gene Sharpr-MPRA regulatory region 9919 Neighboring gene tubulin epsilon and delta complex 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis. Hoffmann C, et al. Oncotarget, 2016 Mar 22. PMID 26883198, Free PMC Article
    2. The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma. Lo PH, et al. Cancer Lett, 2012 Mar. PMID 22154084
    3. Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells. Li F, et al. Biochem Biophys Res Commun, 2021 Dec 20. PMID 34773852
    4. A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation. Tsui SK, et al. Biochem Mol Biol Int, 1996 Jul. PMID 8843343
    5. APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation. Chen L, et al. Angew Chem Int Ed Engl, 2021 Nov 22. PMID 34550632

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells.
      Title: Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells.
    2. APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.
      Title: APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.
    3. HOXA9 inhibits HIF1A-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.
      Title: HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.
    4. High CRP2 expression is associated with breast cancer cell invasion and metastasis.
      Title: CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.
    5. Function of avian CRIP2 in smooth muscle differentiation
      Title: Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.
    6. CRIP2 expression is down-regulated in ESCC tissues and cell lines.
      Title: The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.
    7. CRIP2 acts as a transcription repressor of the NF-kappaB-mediated proangiogenic cytokine expression and thus functionally inhibits tumor formation and angiogenesis
      Title: Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis.
    8. These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2.
      Title: ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cysteine-rich protein 2
    Names
    Cysteine-rich intestinal protein
    LIM domain protein ESP1/CRP2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270837.2 → NP_001257766.1  cysteine-rich protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001257766.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AK300092, AL928654, BC034151, HY161884
      Consensus CDS
      CCDS59246.1
      UniProtKB/Swiss-Prot
      P52943
      Related
      ENSP00000426119.2, ENST00000483017.7
      Conserved Domains (2) summary
      cd09401
      Location:200 → 253
      LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)
      cl02475
      Location:89 → 132
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001270841.2 → NP_001257770.1  cysteine-rich protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001257770.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AL928654, BC034151, BQ684851
      UniProtKB/TrEMBL
      H0YHD8
      Related
      ENSP00000446875.1, ENST00000550577.5
      Conserved Domains (1) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

    3. NM_001312.4 → NP_001303.1  cysteine-rich protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001303.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BC034151
      Consensus CDS
      CCDS10003.1
      UniProtKB/Swiss-Prot
      A1A4U1, B7Z6C0, E9PD13, P52943
      UniProtKB/TrEMBL
      Q53FN1
      Related
      ENSP00000328521.5, ENST00000329146.9
      Conserved Domains (1) summary
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

    RNA

    1. NR_073081.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL928654, BC034151, HY078632

    2. NR_073082.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
      Source sequence(s)
      AL928654, BC034151, BE271979, HY161884

    3. NR_073083.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, compared to variant 1.
      Source sequence(s)
      BC034151, CN367966
      Related
      ENST00000538259.2

    4. NR_073084.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
      Source sequence(s)
      AK091845, AW173606
      Related
      ENST00000548989.5

    5. NR_073085.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
      Source sequence(s)
      AK311402, AL928654, BC034151

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      105472945..105480170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      99720088..99729539
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52943.1 GenPept UniProtKB/Swiss-Prot:P52943

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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