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    INHBA inhibin subunit beta A [ Homo sapiens (human) ]

    Gene ID: 3624, updated on 3-Dec-2024

    Summary

    Official Symbol
    INHBAprovided by HGNC
    Official Full Name
    inhibin subunit beta Aprovided by HGNC
    Primary source
    HGNC:HGNC:6066
    See related
    Ensembl:ENSG00000122641 MIM:147290; AllianceGenome:HGNC:6066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EDF; FRP
    Summary
    This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
    Expression
    Broad expression in endometrium (RPKM 12.3), gall bladder (RPKM 11.3) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See INHBA in Genome Data Viewer
    Location:
    7p14.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (41685114..41705406, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (41843512..41867440, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (41724712..41742688, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375247 Neighboring gene uncharacterized LOC107986789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25899 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:41748736-41749935 Neighboring gene INHBA antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25901 Neighboring gene uncharacterized LOC124901618 Neighboring gene GLI family zinc finger 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:42068797-42069297 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:42105443-42106096 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:42131129-42131824 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 30

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment.
    EBI GWAS Catalog
    Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of inhibin, beta A (INHBA) in human B cells PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of inhibin, beta A (INHBA) in peptide-treated PBMCs PubMed
    Tat tat HIV-1 Tat upregulates the expression of inhibin, beta A (INHBA) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • AC005027.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables type II activin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in GABAergic neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Sertoli cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in androst-4-ene-3,17-dione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cardiac fibroblast cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to angiotensin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cholesterol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to follicle-stimulating hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oxygen-glucose deprivation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in endodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in erythrocyte differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in eyelid development in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hair follicle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hemoglobin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in male gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in mesodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of B cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of follicle-stimulating hormone secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of macrophage differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of type II interferon production TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in odontogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ovarian follicle development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in ovarian follicle development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of collagen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of follicle-stimulating hormone secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ovulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in progesterone secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of follicle-stimulating hormone secretion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to aldosterone IEA
    Inferred from Electronic Annotation
    more info
     
    NOT involved_in response to wounding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in roof of mouth development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in striatal medium spiny neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in testosterone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of activin A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of enzyme activator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of inhibin A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    inhibin beta A chain
    Names
    FSH-releasing protein
    Inhibin, beta-1
    activin beta-A chain
    erythroid differentiation factor
    erythroid differentiation protein
    follicle-stimulating hormone-releasing protein
    inhibin beta A subunit
    inhibin, beta A (activin A, activin AB alpha polypeptide)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002192.4NP_002183.1  inhibin beta A chain preproprotein

      See identical proteins and their annotated locations for NP_002183.1

      Status: REVIEWED

      Source sequence(s)
      AA491465, AC005027, AK001903, AU137531, BC007858
      Consensus CDS
      CCDS5464.1
      UniProtKB/Swiss-Prot
      P08476, Q14599
      UniProtKB/TrEMBL
      A4D1W7, Q53H39, Q9HBP0
      Related
      ENSP00000242208.4, ENST00000242208.5
      Conserved Domains (2) summary
      cd19404
      Location:319426
      TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
      cl02928
      Location:56236
      TGFb_propeptide; TGF-beta propeptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      41685114..41705406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012174.2XP_016867663.2  inhibin beta A chain isoform X1

      UniProtKB/Swiss-Prot
      P08476, Q14599
      UniProtKB/TrEMBL
      A4D1W7, Q53H39, Q9HBP0
      Related
      ENSP00000490646.1, ENST00000638023.1
    2. XM_047420335.1XP_047276291.1  inhibin beta A chain isoform X1

      UniProtKB/Swiss-Prot
      P08476, Q14599
      UniProtKB/TrEMBL
      A4D1W7, Q53H39, Q9HBP0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      41843512..41867440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358159.1XP_054214134.1  inhibin beta A chain isoform X3

      UniProtKB/TrEMBL
      Q53H39, Q9HBP0
    2. XM_054358157.1XP_054214132.1  inhibin beta A chain isoform X2

    3. XM_054358158.1XP_054214133.1  inhibin beta A chain isoform X2