Ckmt2 creatine kinase, mitochondrial 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ckmt2provided by MGI
Official Full Name: creatine kinase, mitochondrial 2provided by MGI
Primary source: MGI:MGI:1923972
See related: Ensembl:ENSMUSG00000021622 AllianceGenome:MGI:1923972
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S-MtCK; mib-CK; ScCKmit; 2300008A19Rik
Summary: Predicted to enable cardiolipin binding activity and creatine kinase activity. Predicted to be involved in phosphocreatine biosynthetic process. Predicted to act upstream of or within phosphocreatine metabolic process. Located in mitochondrion. Is expressed in several structures, including gut; heart; lung; skeletal muscle; and thymus. Orthologous to human CKMT2 (creatine kinase, mitochondrial 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward heart adult (RPKM 839.5) See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 47.43 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (92001510..92025001, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (91853386..91876923, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes.
Title: Decreased mitochondrial creatine kinase 2 impairs skeletal muscle mitochondrial function independently of insulin in type 2 diabetes.
Modest elevation of MtCK activity in the heart does not adversely affect cellular metabolism, mitochondrial or in vivo cardiac function, but modifies mPTP opening to protect against I/R injury and improve functional recovery.
Title: Over-expression of mitochondrial creatine kinase in the murine heart improves functional recovery and protects against injury following ischaemia-reperfusion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ckmt2 (e-PCR), detects polymorphism
- UniSTS:499080

Ckmt2 (e-PCR), detects polymorphism
- UniSTS:515311

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables creatine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables creatine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphocreatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphocreatine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphocreatine metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: creatine kinase S-type, mitochondrial

Names: basic-type mitochondrial creatine kinase; sarcomeric mitochondrial creatine kinase

NP_940807.1

EC 2.7.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198415.4 → NP_940807.1 creatine kinase S-type, mitochondrial precursor

See identical proteins and their annotated locations for NP_940807.1

Status: VALIDATED

Source sequence(s)

AC167972

Consensus CDS

CCDS26679.1

UniProtKB/Swiss-Prot

Q6P8J7

Related

ENSMUSP00000022122.4, ENSMUST00000022122.4

Conserved Domains (1) summary

cd00716
Location:50 → 407

creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes