Gucy2g guanylate cyclase 2g [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gucy2gprovided by MGI
Official Full Name: guanylate cyclase 2gprovided by MGI
Primary source: MGI:MGI:106025
See related: Ensembl:ENSMUSG00000055523 AllianceGenome:MGI:106025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GC-G; 2410077I05Rik
Summary: Enables guanylate cyclase activity. Predicted to be involved in cGMP biosynthetic process and receptor guanylyl cyclase signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; immune system; liver; and musculature. Orthologous to human GUCY2GP (guanylate cyclase 2G, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 1.8), cortex adult (RPKM 1.3) and 9 other tissues See more
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Genomic context

Location:: 19 D2; 19 51.18 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (55186531..55229684, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (55198099..55241252, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

it was observed that dimerization/oligomerization of GC-G, a process generally considered as critical for enzymatic activity of GCs, is strongly enhanced by coolness.
Title: Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures.
mGC-G is a sperm cell surface protein that possibly functions in early signaling event regulating calcium influx/efflux and sperm motility.
Title: Localization and characterization of an orphan receptor, guanylyl cyclase-G, in mouse testis and sperm.
GC-G may act as an early signaling molecule that promotes apoptotic and inflammatory responses in I/R-induced acute renal injury
Title: Disruption of guanylyl cyclase-G protects against acute renal injury.
Cloning of a guanylate cyclase receptor, GC-G, that is selective expressed in the testis [GC-G]
Title: Identification of an orphan guanylate cyclase receptor selectively expressed in mouse testis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gucy2g (e-PCR), detects polymorphism
- UniSTS:525579

Gucy2g (e-PCR), detects polymorphism
- UniSTS:525457

Gucy2g (e-PCR), detects polymorphism
- UniSTS:143281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanylate cyclase 2G

Names: guanylyl cyclase receptor G

NP_001074545.1

EC 4.6.1.2

NP_001357941.1

EC 4.6.1.2

XP_030106960.1

EC 4.6.1.2

XP_030106961.1

EC 4.6.1.2

XP_030106962.1

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081076.3 → NP_001074545.1 guanylate cyclase 2G isoform 1 precursor

See identical proteins and their annotated locations for NP_001074545.1

Status: VALIDATED

Source sequence(s)

AC110206, AC133100

Consensus CDS

CCDS38026.1

UniProtKB/Swiss-Prot

Q6TL19, Q8BWU7

Related

ENSMUSP00000068253.7, ENSMUST00000069183.8

Conserved Domains (3) summary

smart00044
Location:865 → 1055

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cd13992
Location:555 → 829

PK_GC; Pseudokinase domain of membrane Guanylate Cyclase receptors

cd06372
Location:47 → 436

PBP1_GC_G-like; Ligand-binding domain of membrane guanylyl cyclase G
NM_001371012.1 → NP_001357941.1 guanylate cyclase 2G isoform 2

Status: VALIDATED

Source sequence(s)

AC133100, AK049940

Conserved Domains (2) summary

smart00044
Location:224 → 414

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cl21453
Location:30 → 188

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

55186531..55229684 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251102.2 → XP_030106962.1 guanylate cyclase 2G isoform X3

Conserved Domains (2) summary

smart00044
Location:172 → 362

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cl21453
Location:30 → 136

PKc_like; Protein Kinases, catalytic domain
XM_030251100.2 → XP_030106960.1 guanylate cyclase 2G isoform X1

Conserved Domains (2) summary

smart00044
Location:224 → 396

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cl21453
Location:30 → 188

PKc_like; Protein Kinases, catalytic domain
XM_030251101.2 → XP_030106961.1 guanylate cyclase 2G isoform X2

Conserved Domains (2) summary

smart00044
Location:172 → 341

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

cl21453
Location:30 → 136

PKc_like; Protein Kinases, catalytic domain