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    Helz2 helicase with zinc finger 2, transcriptional coactivator [ Mus musculus (house mouse) ]

    Gene ID: 229003, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Helz2provided by MGI
    Official Full Name
    helicase with zinc finger 2, transcriptional coactivatorprovided by MGI
    Primary source
    MGI:MGI:2385169
    See related
    Ensembl:ENSMUSG00000027580 AllianceGenome:MGI:2385169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PDIP1; mPDIP1; Pric285; mKIAA1769
    Summary
    Predicted to enable RNA binding activity; RNA helicase activity; and exoribonuclease II activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm. Predicted to be active in P granule and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and telencephalon. Orthologous to human HELZ2 (helicase with zinc finger 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in spleen adult (RPKM 53.3), thymus adult (RPKM 35.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Helz2 in Genome Data Viewer
    Location:
    2 H4; 2 103.63 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180869408..180883851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181227615..181242058, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 40033 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene STARR-positive B cell enhancer ABC_E4531 Neighboring gene fibronectin type III domain containing 11 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene glucocorticoid modulatory element binding protein 2 Neighboring gene proviral integration site 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor. Yoshino S, et al. Endocrinology, 2014 Sep. PMID 25004093
    2. SFPQ associated with a co-activator for PPARγ, HELZ2, regulates key nuclear factors for adipocyte differentiation. Katano-Toki A, et al. Biochem Biophys Res Commun, 2021 Jul 12. PMID 34052659
    3. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. Katano-Toki A, et al. Mol Endocrinol, 2013 May. PMID 23525231, Free PMC Article
    4. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SFPQ associated with a co-activator for PPARgamma, HELZ2, regulates key nuclear factors for adipocyte differentiation.
      Title: SFPQ associated with a co-activator for PPARγ, HELZ2, regulates key nuclear factors for adipocyte differentiation.
    2. Expression of Lepr in the liver, but not in the hypothalamus, was up-regulated in Helz2 knockout mice.
      Title: Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor.
    3. Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2.
      Title: THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63178

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exoribonuclease II activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables exoribonuclease II activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    3'-5' exoribonuclease HELZ2
    Names
    ATP-dependent RNA helicase PRIC285
    PPAR gamma-DNA-binding domain interacting protein1
    PPAR-gamma DBD-interacting protein 1
    PPAR-gamma DNA-binding domain-interacting protein 1
    helicase with zinc finger domain 2
    peroxisomal proliferator-activated receptor A interacting complex 285
    NP_898985.2
    XP_006500662.1
    XP_006500664.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183162.2 → NP_898985.2  3'-5' exoribonuclease HELZ2

      Status: VALIDATED

      Source sequence(s)
      AK157942, AK168622, AL845506, BF453182
      Consensus CDS
      CCDS38380.1
      UniProtKB/Swiss-Prot
      B9A0U1, E9QAM5
      UniProtKB/TrEMBL
      A2AS05
      Related
      ENSMUSP00000104459.2, ENSMUST00000108831.8
      Conserved Domains (4) summary
      smart00955
      Location:1567 → 1924
      RNB; This domain is the catalytic domain of ribonuclease II
      cd18040
      Location:2448 → 2724
      DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
      pfam13087
      Location:2704 → 2909
      AAA_12; AAA domain
      cl28899
      Location:760 → 990
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180869408..180883851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500601.3 → XP_006500664.1  3'-5' exoribonuclease HELZ2 isoform X2

      UniProtKB/TrEMBL
      A2AS03, A2AS05
      Related
      ENSMUSP00000091756.5, ENSMUST00000094203.11
      Conserved Domains (4) summary
      smart00955
      Location:1567 → 1924
      RNB; This domain is the catalytic domain of ribonuclease II
      cd18040
      Location:2448 → 2724
      DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
      pfam13087
      Location:2704 → 2909
      AAA_12; AAA domain
      cl28899
      Location:760 → 990
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    2. XM_006500599.3 → XP_006500662.1  3'-5' exoribonuclease HELZ2 isoform X1

      UniProtKB/Swiss-Prot
      B9A0U1, E9QAM5
      UniProtKB/TrEMBL
      A2AS05
      Related
      ENSMUSP00000112917.2, ENSMUST00000121484.2
      Conserved Domains (4) summary
      smart00955
      Location:1567 → 1924
      RNB; This domain is the catalytic domain of ribonuclease II
      cd18040
      Location:2448 → 2724
      DEXXc_HELZ2-C; C-terminal DEXX-box helicase domain of HELZ2
      pfam13087
      Location:2704 → 2909
      AAA_12; AAA domain
      cl28899
      Location:760 → 990
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    RNA

    1. XR_003952779.1 RNA Sequence

    2. XR_004940251.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9QAM5.1 GenPept UniProtKB/Swiss-Prot:E9QAM5

    Gene LinkOut

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