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    Rab30 RAB30, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 75985, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab30provided by MGI
    Official Full Name
    RAB30, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1923235
    See related
    Ensembl:ENSMUSG00000030643 AllianceGenome:MGI:1923235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rsb30; 5033421K01Rik
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in Golgi organization and vesicle-mediated transport. Predicted to be located in cis-Golgi network. Predicted to be active in Golgi cisterna and trans-Golgi network. Is expressed in cranial ganglion; hindbrain; and ventral grey horn. Orthologous to human RAB30 (RAB30, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 3.5), CNS E18 (RPKM 2.7) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rab30 in Genome Data Viewer
    Location:
    7 E1; 7 51.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (92390845..92493743)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (92741637..92844535)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2551 Neighboring gene RIKEN cDNA 4632427E13 gene Neighboring gene STARR-seq mESC enhancer starr_19530 Neighboring gene STARR-positive B cell enhancer ABC_E8184 Neighboring gene STARR-seq mESC enhancer starr_19531 Neighboring gene STARR-positive B cell enhancer ABC_E9697 Neighboring gene STARR-seq mESC enhancer starr_19532 Neighboring gene DNA damage-induced apoptosis suppressor Neighboring gene predicted gene, 40448 Neighboring gene prolylcarboxypeptidase (angiotensinase C)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rab30 facilitates lipid homeostasis during fasting. Smith DM, et al. Nat Commun, 2024 May 25. PMID 38796472, Free PMC Article
    2. Expression profiling of Rab GTPases reveals the involvement of Rab20 and Rab32 in acute brain inflammation in mice. Liang Y, et al. Neurosci Lett, 2012 Oct 11. PMID 22960262
    3. Elevation and characteristics of Rab30 and S100a8/S100a9 expression in an early phase of liver regeneration in the mouse. Chiba M, et al. Int J Mol Med, 2011 Apr. PMID 21308349
    4. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
    5. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab30 facilitates lipid homeostasis during fasting.
      Title: Rab30 facilitates lipid homeostasis during fasting.
    2. Rabs may participate in inflammatory response in microglia during brain inflammation.
      Title: Expression profiling of Rab GTPases reveals the involvement of Rab20 and Rab32 in acute brain inflammation in mice.
    3. Rab30 and S100a8/S100a9 were indicated to play roles in the initiation of liver regeneration as well as possibly in the functional switch of the liver in the newborn stage.
      Title: Elevation and characteristics of Rab30 and S100a8/S100a9 expression in an early phase of liver regeneration in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Rab protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi cisterna IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cis-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cis-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029494.2 → NP_083770.2  ras-related protein Rab-30

      See identical proteins and their annotated locations for NP_083770.2

      Status: PROVISIONAL

      Source sequence(s)
      BC017550
      Consensus CDS
      CCDS21450.1
      UniProtKB/Swiss-Prot
      Q3UQR3, Q923S9, Q9D3Q6
      UniProtKB/TrEMBL
      Q0PD24
      Related
      ENSMUSP00000032879.8, ENSMUST00000032879.15
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      92390845..92493743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508294.3 → XP_006508357.1  ras-related protein Rab-30 isoform X1

      See identical proteins and their annotated locations for XP_006508357.1

      UniProtKB/Swiss-Prot
      Q3UQR3, Q923S9, Q9D3Q6
      UniProtKB/TrEMBL
      Q0PD24
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)

    2. XM_030243075.2 → XP_030098935.1  ras-related protein Rab-30 isoform X1

      UniProtKB/Swiss-Prot
      Q3UQR3, Q923S9, Q9D3Q6
      UniProtKB/TrEMBL
      Q0PD24
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)

    3. XM_006508293.5 → XP_006508356.1  ras-related protein Rab-30 isoform X1

      See identical proteins and their annotated locations for XP_006508356.1

      UniProtKB/Swiss-Prot
      Q3UQR3, Q923S9, Q9D3Q6
      UniProtKB/TrEMBL
      Q0PD24
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)

    4. XM_030243074.2 → XP_030098934.1  ras-related protein Rab-30 isoform X1

      UniProtKB/Swiss-Prot
      Q3UQR3, Q923S9, Q9D3Q6
      UniProtKB/TrEMBL
      Q0PD24
      Related
      ENSMUSP00000102798.2, ENSMUST00000107180.8
      Conserved Domains (1) summary
      cd04114
      Location:3 → 171
      Rab30; Rab GTPase family 30 (Rab30)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q923S9.1 GenPept UniProtKB/Swiss-Prot:Q923S9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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