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    Aif1l allograft inflammatory factor 1-like [ Mus musculus (house mouse) ]

    Gene ID: 108897, updated on 4-Jan-2025

    Summary

    Official Symbol
    Aif1lprovided by MGI
    Official Full Name
    allograft inflammatory factor 1-likeprovided by MGI
    Primary source
    MGI:MGI:1919598
    See related
    Ensembl:ENSMUSG00000001864 AllianceGenome:MGI:1919598
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Iba2; 2810003C17Rik
    Summary
    Predicted to enable actin filament binding activity and calcium ion binding activity. Predicted to be involved in actin filament bundle assembly and ruffle assembly. Predicted to be located in actin cytoskeleton and focal adhesion. Predicted to be part of protein-containing complex. Predicted to colocalize with actin filament and ruffle membrane. Is expressed in several structures, including cranium; male reproductive gland or organ; nervous system; otocyst; and stomach. Orthologous to human AIF1L (allograft inflammatory factor 1 like). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in kidney adult (RPKM 41.5), CNS E11.5 (RPKM 11.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Aif1l in Genome Data Viewer
    Location:
    2 B; 2 21.95 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31840315..31863454)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31950303..31973442)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10093 Neighboring gene fibrinogen C domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_04163 Neighboring gene laminin gamma 3 Neighboring gene nucleoporin 214 Neighboring gene BTG3 associated nuclear protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_04165 Neighboring gene predicted gene 13609

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

    General gene information

    Clone Names

    • MGC30545

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding  
    enables actin filament binding  
    enables actin filament binding  
    enables calcium ion binding  
    enables calcium ion binding  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly  
    involved_in ruffle assembly  
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    colocalizes_with actin filament  
    colocalizes_with actin filament  
    colocalizes_with actin filament  
    located_in cytoplasm  
    located_in focal adhesion  
    located_in focal adhesion  
    part_of protein-containing complex  
    colocalizes_with ruffle membrane  
    located_in ruffle membrane  

    General protein information

    Preferred Names
    allograft inflammatory factor 1-like
    Names
    ionized calcium binding adapter molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145144.1NP_660126.1  allograft inflammatory factor 1-like

      See identical proteins and their annotated locations for NP_660126.1

      Status: PROVISIONAL

      Source sequence(s)
      BC024599
      Consensus CDS
      CCDS15904.1
      UniProtKB/Swiss-Prot
      Q8C150, Q9EQX4
      UniProtKB/TrEMBL
      A0A0A6YWH2
      Related
      ENSMUSP00000001920.8, ENSMUST00000001920.13
      Conserved Domains (1) summary
      PTZ00184
      Location:47115
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      31840315..31863454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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