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    Crygf crystallin, gamma F [ Mus musculus (house mouse) ]

    Gene ID: 12969, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Crygfprovided by MGI
    Official Full Name
    crystallin, gamma Fprovided by MGI
    Primary source
    MGI:MGI:88526
    See related
    Ensembl:ENSMUSG00000025945 AllianceGenome:MGI:88526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Len-2; Cryg-2; DGcry-2; 3110001K11Rik
    Summary
    Predicted to be a structural constituent of eye lens. Acts upstream of or within eye development. Is expressed in embryo; eye; head; lens; and retina. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Crygf in Genome Data Viewer
    Location:
    1 C3; 1 33.31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65965681..65967470)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65926522..65928311)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57567 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 16B pseudogene Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01181 Neighboring gene STARR-seq mESC enhancer starr_01182 Neighboring gene cell growth-regulating nucleolar protein Neighboring gene predicted gene 8812

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Developmental regulation and cell type-specific expression of the murine gamma F-crystallin gene is mediated through a lens-specific element containing the gamma F-1 binding site. Goring DR, et al. Dev Dyn, 1993 Feb. PMID 8364223
    2. Functional interactions between retinoic acid receptor-related orphan nuclear receptor (ROR alpha) and the retinoic acid receptors in the regulation of the gamma F-crystallin promoter. Tini M, et al. J Biol Chem, 1995 Aug 25. PMID 7650034
    3. Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity. Graw J, et al. Invest Ophthalmol Vis Sci, 2002 Sep. PMID 12202521
    4. Novel zinc finger proteins that interact with the mouse gamma F-crystallin promoter and are expressed in the sclerotome during early somitogenesis. Liu Q, et al. Dev Biol, 1994 Sep. PMID 8088434
    5. Murine gamma E-crystallin is distinct from murine gamma 2-crystallin. Graw J, et al. Gene, 1991 Aug 15. PMID 1916296

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crygf(Rop) is the first mutation affecting the Crygf gene.
      Title: Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (other) (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-crystallin F
    Names
    gamma-F-crystallin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360779.1 → NP_001347708.1  gamma-crystallin F isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK013953, CA326162, CA452192
      Consensus CDS
      CCDS87841.1
      UniProtKB/TrEMBL
      E9Q3I1
      Related
      ENSMUSP00000109661.3, ENSMUST00000114027.3
      Conserved Domains (1) summary
      smart00247
      Location:3 → 82
      XTALbg; Beta/gamma crystallins

    2. NM_027010.3 → NP_081286.1  gamma-crystallin F isoform 1

      See identical proteins and their annotated locations for NP_081286.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK013953, CA326162
      Consensus CDS
      CCDS15018.1
      UniProtKB/Swiss-Prot
      Q9CXV3
      UniProtKB/TrEMBL
      A2RTH4
      Related
      ENSMUSP00000027082.5, ENSMUST00000027082.11
      Conserved Domains (2) summary
      smart00247
      Location:3 → 82
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:89 → 170
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65965681..65967470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXV3.3 GenPept UniProtKB/Swiss-Prot:Q9CXV3

    Gene LinkOut

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