mt-Atp6 ATP synthase 6, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Atp6provided by MGI
Official Full Name: ATP synthase 6, mitochondrialprovided by MGI
Primary source: MGI:MGI:99927
See related: AllianceGenome:MGI:99927
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATP6
Summary: Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrion. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. Orthologous to human MT-ATP6 (mitochondrially encoded ATP synthase membrane subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (7927..8607)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (7927..8607)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Mutation in Mouse MT-ATP6 Gene Induces Respiration Defects and Opposed Effects on the Cell Tumorigenic Phenotype.
Title: A Mutation in Mouse MT-ATP6 Gene Induces Respiration Defects and Opposed Effects on the Cell Tumorigenic Phenotype.
Mice were created that allotopically express either a mutant (A6M) or wildtype (A6W) mt-Atp6 transgene.
Title: Nuclear expression of a mitochondrial DNA gene: mitochondrial targeting of allotopically expressed mutant ATP6 in transgenic mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136459 (e-PCR)
- UniSTS:210445

RH125504 (e-PCR)
- UniSTS:162322

RH136484 (e-PCR)
- UniSTS:210468

mt-Co3 (e-PCR), detects polymorphism
- UniSTS:143918

RH136229 (e-PCR)
- UniSTS:210223

RH136241 (e-PCR)
- UniSTS:210235

RH136529 (e-PCR)
- UniSTS:210511

RH136532 (e-PCR)
- UniSTS:210514

RH136545 (e-PCR)
- UniSTS:210527

NoName (e-PCR)
- UniSTS:234086

RH136286 (e-PCR)
- UniSTS:210279

NoName (e-PCR)
- UniSTS:234087

NoName (e-PCR)
- UniSTS:234088

NoName (e-PCR)
- UniSTS:234091

NoName (e-PCR)
- UniSTS:234093

RH136324 (e-PCR)
- UniSTS:210315

RH136327 (e-PCR)
- UniSTS:210317

RH136597 (e-PCR)
- UniSTS:210577

mt-Atp6 (e-PCR), detects polymorphism
- UniSTS:536472

mt-Atp6 (e-PCR), detects polymorphism
- UniSTS:536473

RH136345 (e-PCR)
- UniSTS:210335

RH136387 (e-PCR)
- UniSTS:210377

RH136391 (e-PCR)
- UniSTS:210381

RH136401 (e-PCR)
- UniSTS:210391

RH136408 (e-PCR)
- UniSTS:210398

RH136413 (e-PCR)
- UniSTS:210403

RH136419 (e-PCR)
- UniSTS:210409

RH125483 (e-PCR)
- UniSTS:162302

Homology

Orthologs from OrthoDB

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to proton-transporting ATP synthase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven mitochondrial ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in response to hyperoxia	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
part_of proton-transporting ATP synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	ISS Inferred from Sequence or Structural Similarity more info