Klf7 Kruppel-like transcription factor 7 (ubiquitous) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klf7provided by MGI
Official Full Name: Kruppel-like transcription factor 7 (ubiquitous)provided by MGI
Primary source: MGI:MGI:1935151
See related: Ensembl:ENSMUSG00000025959 AllianceGenome:MGI:1935151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9830124P08Rik
Summary: Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within axon guidance; dendrite morphogenesis; and positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including genitourinary system; gut; immune system; nervous system; and sensory organ. Orthologous to human KLF7 (KLF transcription factor 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 10.9), whole brain E14.5 (RPKM 9.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 32.31 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (64068607..64161504, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (64029448..64122345, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-520f-3p blocks MNNG-induced gastric precancerous lesions via the KLF7/NFkappaB pathway.
Title: miR-520f-3p blocks MNNG-induced gastric precancerous lesions via the KLF7/NFκB pathway.
KLF7 promotes adipocyte inflammation and glucose metabolism disorder by activating the PKCzeta/NF-kappaB pathway.
Title: KLF7 promotes adipocyte inflammation and glucose metabolism disorder by activating the PKCζ/NF-κB pathway.
The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice.
Title: The KLF7/PFKL/ACADL axis modulates cardiac metabolic remodelling during cardiac hypertrophy in male mice.
KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.
Title: KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.
Kruppel-like Transcription Factor 7 Is a Causal Gene in Autism Development.
Title: Krüppel-like Transcription Factor 7 Is a Causal Gene in Autism Development.
Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7.
Title: Methylation of miR-19b-3p promoter exacerbates inflammatory responses in sepsis-induced ALI via targeting KLF7.
MicroRNA-136-3p inhibits glioma tumorigenesis in vitro and in vivo by targeting KLF7.
Title: MicroRNA-136-3p inhibits glioma tumorigenesis in vitro and in vivo by targeting KLF7.
KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity.
Title: KLF7 promotes pancreatic cancer growth and metastasis by up-regulating ISG expression and maintaining Golgi complex integrity.
KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration.
Title: KLF7 overexpression in bone marrow stromal stem cells graft transplantation promotes sciatic nerve regeneration.
Mechanistically, KLF7 transcriptionally activated argininosuccinate lyase (ASL), which was observed highly expressed in glioma tissues. KLF7 accelerates the xenografted tumor growth of glioma cells. KLF7 potentiates polyamine biosynthesis and glioma cell growth via transcriptionally activates ASL.
Title: KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126692 (e-PCR)
- UniSTS:209729

Klf7 (e-PCR), detects polymorphism
- UniSTS:531340

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adipose tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in regulation of epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Krueppel-like factor 7

Names: Kruppel-like factor 7 (ubiquitous)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033563.2 → NP_291041.2 Krueppel-like factor 7

See identical proteins and their annotated locations for NP_291041.2

Status: PROVISIONAL

Source sequence(s)

BC019604

Consensus CDS

CCDS15003.1

UniProtKB/Swiss-Prot

Q99JB0, Q99P62

UniProtKB/TrEMBL

Q3UES6

Related

ENSMUSP00000109720.3, ENSMUST00000114086.8

Conserved Domains (5) summary

COG5048
Location:211 → 283

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 242

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:278 → 300

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:264 → 289

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 219

KLF7_N; N-terminal domain of Kruppel-like factor 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

64068607..64161504 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243769.1 → XP_030099629.1 Krueppel-like factor 7 isoform X2

UniProtKB/Swiss-Prot

Q99JB0, Q99P62

UniProtKB/TrEMBL

Q3UES6

Conserved Domains (5) summary

COG5048
Location:211 → 283

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 242

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:278 → 300

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:264 → 289

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 219

KLF7_N; N-terminal domain of Kruppel-like factor 7
XM_030243770.1 → XP_030099630.1 Krueppel-like factor 7 isoform X2

UniProtKB/Swiss-Prot

Q99JB0, Q99P62

UniProtKB/TrEMBL

Q3UES6

Conserved Domains (5) summary

COG5048
Location:211 → 283

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 242

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:278 → 300

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:264 → 289

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 219

KLF7_N; N-terminal domain of Kruppel-like factor 7
XM_006496352.5 → XP_006496415.1 Krueppel-like factor 7 isoform X1

See identical proteins and their annotated locations for XP_006496415.1

UniProtKB/TrEMBL

Q3UES6

Conserved Domains (5) summary

COG5048
Location:223 → 281

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 242

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:279 → 301

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:265 → 290

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 219

KLF7_N; N-terminal domain of Kruppel-like factor 7
XM_006496353.4 → XP_006496416.1 Krueppel-like factor 7 isoform X1

See identical proteins and their annotated locations for XP_006496416.1

UniProtKB/TrEMBL

Q3UES6

Conserved Domains (5) summary

COG5048
Location:223 → 281

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 242

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:279 → 301

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:265 → 290

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 219

KLF7_N; N-terminal domain of Kruppel-like factor 7
XM_006496354.4 → XP_006496417.1 Krueppel-like factor 7 isoform X2

See identical proteins and their annotated locations for XP_006496417.1

UniProtKB/Swiss-Prot

Q99JB0, Q99P62

UniProtKB/TrEMBL

Q3UES6

Conserved Domains (5) summary

COG5048
Location:211 → 283

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 242

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:278 → 300

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:264 → 289

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 219

KLF7_N; N-terminal domain of Kruppel-like factor 7
XM_006496351.4 → XP_006496414.1 Krueppel-like factor 7 isoform X1

See identical proteins and their annotated locations for XP_006496414.1

UniProtKB/TrEMBL

Q3UES6

Conserved Domains (5) summary

COG5048
Location:223 → 281

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:223 → 242

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:279 → 301

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:265 → 290

zf-H2C2_2; Zinc-finger double domain

cd21585
Location:2 → 219

KLF7_N; N-terminal domain of Kruppel-like factor 7