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    Fcrlb Fc receptor-like B [ Mus musculus (house mouse) ]

    Gene ID: 435653, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fcrlbprovided by MGI
    Official Full Name
    Fc receptor-like Bprovided by MGI
    Primary source
    MGI:MGI:3576487
    See related
    Ensembl:ENSMUSG00000070524 AllianceGenome:MGI:3576487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fcry; FREB2; FcRL2; FREB-2; Fcrlm2; mFCRL2
    Summary
    Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within negative regulation of immune response. Predicted to be located in cytoplasm. Predicted to be active in external side of plasma membrane. Orthologous to human FCRLB (Fc receptor like B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Fcrlb in Genome Data Viewer
    Location:
    1 H3; 1 77.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170734284..170741396, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170906715..170913829, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene activating transcription factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E5842 Neighboring gene STARR-seq mESC enhancer starr_02996 Neighboring gene predicted gene 9929 Neighboring gene dual specificity phosphatase 12 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene STARR-positive B cell enhancer ABC_E3326 Neighboring gene STARR-positive B cell enhancer ABC_E5844 Neighboring gene Fc receptor-like A Neighboring gene STARR-positive B cell enhancer ABC_E9496 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene predicted gene, 39701

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells. Jackson TA, et al. J Immunol, 2010 Dec 15. PMID 21068405, Free PMC Article
    2. FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation. Masuda K, et al. Gene, 2005 Dec 19. PMID 16263223
    3. Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory FcγRIIb. Masuda K, et al. Cell Immunol, 2010. PMID 20869045, Free PMC Article
    4. Species-specific evolution of the FcR family in endothermic vertebrates. Fayngerts SA, et al. Immunogenetics, 2007 Jun. PMID 17356879
    5. New nomenclature for Fc receptor-like molecules. Maltais LJ, et al. Nat Immunol, 2006 May. PMID 16622424

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a negative immunomodulatory function for FCRL2 in the regulation of memory B cells.
      Title: FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells.
    2. In FCRLB knock-out mice, B-cell developmemt and in vitro response were normal, but in vivo antibody responses to a T-dependent antigen were elevated. The latter response may be due to a promoter polymorphism in the 129/Sv knock-out strain's Fcgr2b allele.
      Title: Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory FcγRIIb.
    3. Fcry is upregulated by short-term treatment with BAFF/BLyS, which promotes B cell survival rather than proliferation
      Title: FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like B
    Names
    Fc receptor homolog expressed in B-cells protein 2
    Fc receptor related Y
    Fc receptor-like mucin-like 2
    fc receptor homolog expressed in B cells protein 2
    fc receptor-like and mucin-like protein 2
    fc receptor-like protein 2
    fc receptor-related protein Y

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029984.2 → NP_001025155.2  Fc receptor-like B precursor

      See identical proteins and their annotated locations for NP_001025155.2

      Status: VALIDATED

      Source sequence(s)
      AC113490, DQ119292
      Consensus CDS
      CCDS15475.1
      UniProtKB/Swiss-Prot
      F8VQL1, Q5DRQ8
      Related
      ENSMUSP00000091895.2, ENSMUST00000094337.2
      Conserved Domains (3) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:104 → 186
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:114 → 190
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      170734284..170741396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496932.4 → XP_006496995.1  Fc receptor-like B isoform X1

      See identical proteins and their annotated locations for XP_006496995.1

      Conserved Domains (2) summary
      cd05752
      Location:62 → 139
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:143 → 225
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

    2. XM_006496931.4 → XP_006496994.1  Fc receptor-like B isoform X1

      See identical proteins and their annotated locations for XP_006496994.1

      Conserved Domains (2) summary
      cd05752
      Location:62 → 139
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      cd05753
      Location:143 → 225
      Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DRQ8.2 GenPept UniProtKB/Swiss-Prot:Q5DRQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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