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    Myo15a myosin XVA [ Mus musculus (house mouse) ]

    Gene ID: 17910, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myo15aprovided by MGI
    Official Full Name
    myosin XVAprovided by MGI
    Primary source
    MGI:MGI:1261811
    See related
    Ensembl:ENSMUSG00000042678 AllianceGenome:MGI:1261811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sh2; sh-2; Myo15
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within inner ear morphogenesis; locomotory behavior; and sensory perception of sound. Located in stereocilium. Is expressed in several structures, including brain; heart; inner ear; liver; and metanephros. Used to study autosomal recessive nonsyndromic deafness 3. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 2.4), cerebellum adult (RPKM 0.5) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myo15a in Genome Data Viewer
    Location:
    11 B2; 11 37.81 cM
    Exon count:
    67
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60360165..60419195)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60469339..60528369)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60267901-60268133 Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene developmentally regulated GTP binding protein 2 Neighboring gene predicted gene, 51901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60350718-60350827 Neighboring gene predicted gene, 53694 Neighboring gene alkB homolog 5, RNA demethylase Neighboring gene ubiquitin-60S ribosomal protein L40 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (4)  1 citation
    • Endonuclease-mediated (3) 
    • Radiation induced (1) 
    • Spontaneous (2) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to light stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to light stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stereocilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    unconventional myosin-XV
    Names
    shaker 2
    unconventional myosin-15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103171.1NP_001096641.1  unconventional myosin-XV isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AL596090, AL596386, AY331132
      Consensus CDS
      CCDS48811.1
      UniProtKB/Swiss-Prot
      Q9QZZ4
      Related
      ENSMUSP00000091686.3, ENSMUST00000094135.9
      Conserved Domains (7) summary
      smart00139
      Location:30133167
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:12011883
      MYSc; Myosin. Large ATPases
      smart00295
      Location:31773382
      B41; Band 4.1 homologues
      cd13201
      Location:33783479
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:32723372
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:12201871
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      cl17036
      Location:28342913
      SH3; Src Homology 3 domain superfamily
    2. NM_010862.2NP_034992.2  unconventional myosin-XV isoform 1

      See identical proteins and their annotated locations for NP_034992.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF144095, AL596090, AL596386
      Consensus CDS
      CCDS24792.1
      UniProtKB/Swiss-Prot
      A2A637, A2A638, O70395, Q5SX93, Q7TMR5, Q7TMR6, Q9QWL6, Q9QZZ4
      Related
      ENSMUSP00000071777.3, ENSMUST00000071880.9
      Conserved Domains (8) summary
      smart00139
      Location:30313185
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:12011883
      MYSc; Myosin. Large ATPases
      smart00295
      Location:31953400
      B41; Band 4.1 homologues
      cd13201
      Location:33963497
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:32903390
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:12201871
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      pfam02050
      Location:18701960
      FliJ; Flagellar FliJ protein
      cl17036
      Location:28522931
      SH3; Src Homology 3 domain superfamily
    3. NM_182698.2NP_874357.2  unconventional myosin-XV isoform 2a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region, compared to variant 1, resulting in a protein (isoform 2a) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL596386, AY331133
      Consensus CDS
      CCDS24793.1
      UniProtKB/Swiss-Prot
      Q9QZZ4
      Related
      ENSMUSP00000080507.6, ENSMUST00000081823.12
      Conserved Domains (7) summary
      smart00139
      Location:18261980
      MyTH4; Domain in Myosin and Kinesin Tails
      smart00242
      Location:14696
      MYSc; Myosin. Large ATPases
      smart00295
      Location:19902195
      B41; Band 4.1 homologues
      cd13201
      Location:21912292
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:20852185
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:33684
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      cl17036
      Location:16471726
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      60360165..60419195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314331.2XP_017169820.1  unconventional myosin-XV isoform X13

      UniProtKB/TrEMBL
      F6VXK7
      Related
      ENSMUSP00000120839.2, ENSMUST00000126522.4
      Conserved Domains (5) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:772918
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11391377
      PHA03247; large tegument protein UL36; Provisional
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15871666
      SH3; Src Homology 3 domain superfamily
    2. XM_017314330.2XP_017169819.1  unconventional myosin-XV isoform X12

      UniProtKB/TrEMBL
      F6VXK7
      Conserved Domains (5) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:772918
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11391377
      PHA03247; large tegument protein UL36; Provisional
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15871666
      SH3; Src Homology 3 domain superfamily
    3. XM_017314329.2XP_017169818.1  unconventional myosin-XV isoform X11

      UniProtKB/TrEMBL
      F6VXK7
      Conserved Domains (5) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17661920
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11391377
      PHA03247; large tegument protein UL36; Provisional
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15871666
      SH3; Src Homology 3 domain superfamily
    4. XM_017314324.3XP_017169813.1  unconventional myosin-XV isoform X6

      Conserved Domains (7) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17391893
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11641350
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:21042205
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:19982098
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15601639
      SH3; Src Homology 3 domain superfamily
    5. XM_017314320.3XP_017169809.1  unconventional myosin-XV isoform X2

      Conserved Domains (7) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17661920
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11391377
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:21312232
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:20252125
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15871666
      SH3; Src Homology 3 domain superfamily
    6. XM_017314319.3XP_017169808.1  unconventional myosin-XV isoform X1

      Conserved Domains (7) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17661920
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11391377
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:21312232
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:20252125
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15871666
      SH3; Src Homology 3 domain superfamily
    7. XM_017314328.3XP_017169817.1  unconventional myosin-XV isoform X10

      Conserved Domains (7) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17041857
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11391377
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:20682169
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:19622062
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15871666
      SH3; Src Homology 3 domain superfamily
    8. XM_017314321.3XP_017169810.1  unconventional myosin-XV isoform X3

      Conserved Domains (7) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17651919
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11381376
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:21302231
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:20242124
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15861665
      SH3; Src Homology 3 domain superfamily
    9. XM_017314327.3XP_017169816.1  unconventional myosin-XV isoform X9

      Conserved Domains (8) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17231877
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:10961334
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:20882189
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:19822082
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl02480
      Location:772875
      MyTH4; MyTH4 domain
      cl17036
      Location:15441623
      SH3; Src Homology 3 domain superfamily
    10. XM_017314323.3XP_017169812.1  unconventional myosin-XV isoform X5

      Conserved Domains (7) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17481902
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11211359
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:21132214
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:20072107
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15691648
      SH3; Src Homology 3 domain superfamily
    11. XM_017314326.3XP_017169815.1  unconventional myosin-XV isoform X8

      Conserved Domains (7) summary
      smart00015
      Location:594615
      IQ; Calmodulin-binding motif
      smart00139
      Location:17281882
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11011339
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:20932194
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:19872087
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53556
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15491628
      SH3; Src Homology 3 domain superfamily
    12. XM_017314325.3XP_017169814.1  unconventional myosin-XV isoform X7

      Conserved Domains (7) summary
      smart00015
      Location:594615
      IQ; Calmodulin-binding motif
      smart00139
      Location:17281882
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11011339
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:20932194
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:19872087
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53556
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15491628
      SH3; Src Homology 3 domain superfamily
    13. XM_017314322.3XP_017169811.1  unconventional myosin-XV isoform X4

      Conserved Domains (7) summary
      smart00015
      Location:632653
      IQ; Calmodulin-binding motif
      smart00139
      Location:17551909
      MyTH4; Domain in Myosin and Kinesin Tails
      PHA03247
      Location:11391377
      PHA03247; large tegument protein UL36; Provisional
      cd13201
      Location:21202221
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:20142114
      FERM_B-lobe; FERM domain B-lobe
      cl22853
      Location:53594
      Motor_domain; Myosin and Kinesin motor domain
      cl17036
      Location:15761655
      SH3; Src Homology 3 domain superfamily

    RNA

    1. XR_001779911.2 RNA Sequence