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    Trappc2b trafficking protein particle complex 2B [ Mus musculus (house mouse) ]

    Gene ID: 66050, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trappc2bprovided by MGI
    Official Full Name
    trafficking protein particle complex 2Bprovided by MGI
    Primary source
    MGI:MGI:1913300
    See related
    Ensembl:ENSMUSG00000007777 AllianceGenome:MGI:1913300
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610009B22Rik
    Summary
    Predicted to enable transcription corepressor binding activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. Predicted to be part of TRAPP complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including endocrine gland; gallbladder; genitourinary system; nervous system; and skeletal muscle tissue. Human ortholog(s) of this gene implicated in X-linked spondyloepiphyseal dysplasia tarda. Orthologous to human TRAPPC2 (trafficking protein particle complex subunit 2) and TRAPPC2B (trafficking protein particle complex subunit 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.5), CNS E14 (RPKM 9.3) and 28 other tissues See more
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    Genomic context

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    See Trappc2b in Genome Data Viewer
    Location:
    11 B1.3; 11 31.26 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (51576207..51579929, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (51685380..51689104, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3948 Neighboring gene RIKEN cDNA D930048N14 gene Neighboring gene NEDD4 binding protein 3 Neighboring gene predicted gene, 30058 Neighboring gene STARR-seq mESC enhancer starr_29425 Neighboring gene STARR-seq mESC enhancer starr_29426 Neighboring gene STARR-positive B cell enhancer ABC_E6981 Neighboring gene STARR-seq mESC enhancer starr_29427 Neighboring gene STARR-seq mESC enhancer starr_29428 Neighboring gene SEC24 homolog A, COPII coat complex component Neighboring gene predicted gene, 25291 Neighboring gene secretion associated Ras related GTPase 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Trafficking protein particle complex subunit 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417819.1 → NP_001404748.1  Trafficking protein particle complex subunit 2-like

      Status: VALIDATED

      Source sequence(s)
      AL645602
      UniProtKB/TrEMBL
      Q8R3W2

    2. NM_001417820.1 → NP_001404749.1  Trafficking protein particle complex subunit 2-like

      Status: VALIDATED

      Source sequence(s)
      AL645602
      UniProtKB/TrEMBL
      Q8R3W2
      Related
      ENSMUSP00000104726.2, ENSMUST00000109098.2

    3. NM_001417822.1 → NP_001404751.1  Trafficking protein particle complex subunit 2-like

      Status: VALIDATED

      Source sequence(s)
      AL645602
      UniProtKB/TrEMBL
      Q8R3W2

    4. NM_001417823.1 → NP_001404752.1  Trafficking protein particle complex subunit 2-like

      Status: VALIDATED

      Source sequence(s)
      AL645602
      UniProtKB/TrEMBL
      Q8R3W2

    5. NM_025319.3 → NP_079595.1  Trafficking protein particle complex subunit 2-like

      See identical proteins and their annotated locations for NP_079595.1

      Status: VALIDATED

      Source sequence(s)
      AL645602
      Consensus CDS
      CCDS36149.1
      UniProtKB/TrEMBL
      Q8R3W2
      Related
      ENSMUSP00000007921.3, ENSMUST00000007921.9
      Conserved Domains (1) summary
      cd14825
      Location:4 → 138
      TRAPPC2_sedlin; Trafficking protein particle complex subunit 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      51576207..51579929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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