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    Prox2 prospero homeobox 2 [ Mus musculus (house mouse) ]

    Gene ID: 73422, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prox2provided by MGI
    Official Full Name
    prospero homeobox 2provided by MGI
    Primary source
    MGI:MGI:1920672
    See related
    Ensembl:ENSMUSG00000042320 AllianceGenome:MGI:1920672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700058C01Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human PROX2 (prospero homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 8.5), cortex adult (RPKM 2.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prox2 in Genome Data Viewer
    Location:
    12 D1; 12 39.54 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85132584..85157606, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85085810..85110885, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923 Neighboring gene FCF1 rRNA processing protein Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene YLP motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene STARR-seq mESC enhancer starr_32762 Neighboring gene prospero homeobox 2 opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86464102-86464289 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene ribosomal protein S6 kinase-like 1 Neighboring gene STARR-seq mESC enhancer starr_32766 Neighboring gene placental growth factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel prospero-related homeobox gene, Prox2. Nishijima I, et al. Mol Genet Genomics, 2006 May. PMID 16470382
    2. Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia. Kirjavainen A, et al. Dev Biol, 2008 Oct 1. PMID 18652815
    3. Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. Lowenstein ED, et al. Neuron, 2023 Jul 19. PMID 37192624
    4. Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control. Furlan A, et al. Nat Neurosci, 2016 Oct. PMID 27571008
    5. Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion. Lanier J, et al. Dev Dyn, 2009 Dec. PMID 19877281, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
      Title: Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
    2. Compared to mouse Prox1, mouse Prox2 is dispensable for embryonic development, retinal horizontal cell generation, and fertility.
      Title: Characterization of a novel prospero-related homeobox gene, Prox2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 1700058C01Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prospero homeobox protein 2
    Names
    homeobox prospero-like protein PROX2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361238.1 → NP_001348167.1  prospero homeobox protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC127582, AK029978
      Consensus CDS
      CCDS36495.1
      UniProtKB/Swiss-Prot
      Q8BII1
      Related
      ENSMUSP00000135881.2, ENSMUST00000177289.9
      Conserved Domains (2) summary
      PHA03247
      Location:27 → 443
      PHA03247; large tegument protein UL36; Provisional
      pfam05044
      Location:435 → 586
      HPD; Homeo-prospero domain

    2. NM_001361239.2 → NP_001348168.1  prospero homeobox protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC127582
      Consensus CDS
      CCDS36495.1
      UniProtKB/Swiss-Prot
      Q8BII1
      Conserved Domains (2) summary
      PHA03247
      Location:27 → 443
      PHA03247; large tegument protein UL36; Provisional
      pfam05044
      Location:435 → 586
      HPD; Homeo-prospero domain

    3. NM_175198.6 → NP_780407.1  prospero homeobox protein 2

      See identical proteins and their annotated locations for NP_780407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC127582
      Consensus CDS
      CCDS36495.1
      UniProtKB/Swiss-Prot
      Q8BII1
      Related
      ENSMUSP00000105878.3, ENSMUST00000110249.3
      Conserved Domains (2) summary
      PHA03247
      Location:27 → 443
      PHA03247; large tegument protein UL36; Provisional
      pfam05044
      Location:435 → 586
      HPD; Homeo-prospero domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      85132584..85157606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516281.5 → XP_006516344.1  prospero homeobox protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006516344.1

      UniProtKB/Swiss-Prot
      Q8BII1
      Conserved Domains (2) summary
      PHA03247
      Location:27 → 443
      PHA03247; large tegument protein UL36; Provisional
      pfam05044
      Location:435 → 586
      HPD; Homeo-prospero domain

    2. XM_030246952.2 → XP_030102812.1  prospero homeobox protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BII1
      Conserved Domains (2) summary
      PHA03247
      Location:27 → 443
      PHA03247; large tegument protein UL36; Provisional
      pfam05044
      Location:435 → 586
      HPD; Homeo-prospero domain

    3. XM_017315213.3 → XP_017170702.2  prospero homeobox protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BII1
      Conserved Domains (2) summary
      PHA03247
      Location:27 → 443
      PHA03247; large tegument protein UL36; Provisional
      pfam05044
      Location:435 → 586
      HPD; Homeo-prospero domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BII1.1 GenPept UniProtKB/Swiss-Prot:Q8BII1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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