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    Crhbp corticotropin releasing hormone binding protein [ Mus musculus (house mouse) ]

    Gene ID: 12919, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crhbpprovided by MGI
    Official Full Name
    corticotropin releasing hormone binding proteinprovided by MGI
    Primary source
    MGI:MGI:88497
    See related
    Ensembl:ENSMUSG00000021680 AllianceGenome:MGI:88497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CRH-BP
    Summary
    Enables corticotropin-releasing hormone binding activity. Involved in several processes, including cellular response to cAMP; cellular response to estradiol stimulus; and cellular response to gonadotropin-releasing hormone. Acts upstream of or within hormone metabolic process. Located in extracellular space and nucleus. Is expressed in adrenal gland; central nervous system; eye; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human CRHBP (corticotropin releasing hormone binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 5.5), cortex adult (RPKM 5.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Crhbp in Genome Data Viewer
    Location:
    13 D1; 13 49.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95567884..95581339, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95431376..95444831, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr13:96117046-96117346 Neighboring gene predicted gene, 53806 Neighboring gene angiogenic factor with G patch and FHA domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E7266 Neighboring gene STARR-seq mESC enhancer starr_35322 Neighboring gene STARR-positive B cell enhancer ABC_E3093 Neighboring gene STARR-seq mESC enhancer starr_35323 Neighboring gene predicted gene, 52025 Neighboring gene S100 calcium binding protein, zeta Neighboring gene F2R like trypsin receptor 1 Neighboring gene predicted gene, 53807

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables corticotropin-releasing hormone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables corticotropin-releasing hormone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables corticotropin-releasing hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables corticotropin-releasing hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to ethanol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to cocaine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to estrogen stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to gonadotropin-releasing hormone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to immobilization stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to immobilization stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to potassium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to potassium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female pregnancy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within hormone metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in maternal aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of corticotropin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of corticotropin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of corticotropin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of corticotropin-releasing hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of corticotropin-releasing hormone receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of NMDA receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cellular response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of corticotropin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of corticotropin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic transmission, dopaminergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dense core granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dense core granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in multivesicular body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secondary lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secondary lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in varicosity ISO
    Inferred from Sequence Orthology
    more info
     
    located_in varicosity ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    corticotropin-releasing factor-binding protein
    Names
    CRF-BP
    CRF-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198408.3NP_940800.1  corticotropin-releasing factor-binding protein precursor

      See identical proteins and their annotated locations for NP_940800.1

      Status: VALIDATED

      Source sequence(s)
      AI854101, AK135067
      Consensus CDS
      CCDS26698.1
      UniProtKB/Swiss-Prot
      Q60571
      UniProtKB/TrEMBL
      A0A217FL62, Q3UY07
      Related
      ENSMUSP00000152083.2, ENSMUST00000221025.2
      Conserved Domains (1) summary
      pfam05428
      Location:1307
      CRF-BP; Corticotropin-releasing factor binding protein (CRF-BP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      95567884..95581339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)