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    Sv2c synaptic vesicle glycoprotein 2c [ Mus musculus (house mouse) ]

    Gene ID: 75209, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sv2cprovided by MGI
    Official Full Name
    synaptic vesicle glycoprotein 2cprovided by MGI
    Primary source
    MGI:MGI:1922459
    See related
    Ensembl:ENSMUSG00000051111 AllianceGenome:MGI:1922459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930527L09Rik
    Summary
    Predicted to enable transmembrane transporter activity. Involved in regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in dopaminergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SV2C (synaptic vesicle glycoprotein 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 6.9), frontal lobe adult (RPKM 2.3) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sv2c in Genome Data Viewer
    Location:
    13 D1; 13 50.47 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (96091102..96270837, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95959443..96132577, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene IQ motif containing GTPase activating protein 2 Neighboring gene predicted gene, 32702 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662105-96662214 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662521-96662711 Neighboring gene predicted gene, 24032 Neighboring gene STARR-positive B cell enhancer mm9_chr13:96730579-96730880 Neighboring gene STARR-seq mESC enhancer starr_35333 Neighboring gene predicted gene, 57605 Neighboring gene STARR-seq mESC enhancer starr_35337 Neighboring gene basic transcription factor 3 like 4B Neighboring gene predicted gene 17190 Neighboring gene predicted gene, 23955 Neighboring gene predicted gene 29543 Neighboring gene STARR-seq mESC enhancer starr_35340 Neighboring gene STARR-seq mESC enhancer starr_35341 Neighboring gene STARR-seq mESC enhancer starr_35342 Neighboring gene STARR-seq mESC enhancer starr_35344 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:97157941-97158317 Neighboring gene SNF8, ESCRT-II complex subunit, homolog pseudogene Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene POC5 centriolar protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in dopaminergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dopaminergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    synaptic vesicle glycoprotein 2C
    Names
    synaptic vesicle protein 2C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029210.1NP_083486.1  synaptic vesicle glycoprotein 2C

      See identical proteins and their annotated locations for NP_083486.1

      Status: VALIDATED

      Source sequence(s)
      AC129327, AC153134
      Consensus CDS
      CCDS49333.1
      UniProtKB/Swiss-Prot
      Q69ZS6
      UniProtKB/TrEMBL
      A2RSH4
      Related
      ENSMUSP00000124473.2, ENSMUST00000161263.8
      Conserved Domains (1) summary
      TIGR01299
      Location:1727
      synapt_SV2; synaptic vesicle protein SV2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      96091102..96270837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158202.1XP_036014095.1  synaptic vesicle glycoprotein 2C isoform X1

      UniProtKB/Swiss-Prot
      Q69ZS6
      UniProtKB/TrEMBL
      A2RSH4
      Conserved Domains (1) summary
      TIGR01299
      Location:1727
      synapt_SV2; synaptic vesicle protein SV2
    2. XM_030247440.2XP_030103300.1  synaptic vesicle glycoprotein 2C isoform X2

      Conserved Domains (1) summary
      TIGR01299
      Location:22307
      synapt_SV2; synaptic vesicle protein SV2