Ptprg protein tyrosine phosphatase receptor type G [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprgprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Gprovided by MGI
Primary source: MGI:MGI:97814
See related: Ensembl:ENSMUSG00000121513 AllianceGenome:MGI:97814
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RPTPgamma; 5430405N12Rik
Summary: Predicted to enable identical protein binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including negative regulation of epithelial cell migration; negative regulation of neuron projection development; and neuron projection development. Predicted to be located in extracellular space. Is expressed in several structures, including central nervous system and retina. Orthologous to human PTPRG (protein tyrosine phosphatase receptor type G). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 13.7), ovary adult (RPKM 13.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A1; 14 6.33 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (10227722..10916341, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (11553440..12242041)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPRG is an ischemia risk locus essential for HCO3(-)-dependent regulation of endothelial function and tissue perfusion.
Title: PTPRG is an ischemia risk locus essential for HCO(3)(-)-dependent regulation of endothelial function and tissue perfusion.
vasoconstriction promoted through RPTPgamma-dependent changes in VSMC Ca(2+)-sensitivity
Title: Extracellular HCO3- is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ.
Protein-tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system
Title: Structural Basis for Interactions Between Contactin Family Members and Protein-tyrosine Phosphatase Receptor Type G in Neural Tissues.
Results demonstrate that PTPRG plasmatic form (sPTPRG) represent a novel candidate protein biomarker in plasma whose increased expression is associated to hepatocyte damage.
Title: Identification of protein tyrosine phosphatase receptor gamma extracellular domain (sPTPRG) as a natural soluble protein in plasma.
confirm previous findings and enrich the current knowledge of RPTPgamma distribution in the CNS, highlighting a role of RPTPgamma during neuroinflammation processes
Title: Distribution of different isoforms of receptor protein tyrosine phosphatase γ (Ptprg-RPTP γ) in adult mouse brain: upregulation during neuroinflammation.
RPTPgamma is expressed in a variety of tissues during embryogenesis.
Title: Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW046354 (e-PCR)
- UniSTS:165895

NoName (e-PCR)
- UniSTS:237120

NoName (e-PCR)
- UniSTS:237121

AU017971 (e-PCR)
- UniSTS:209005

Ptprg (e-PCR), detects polymorphism
- UniSTS:536488

D14Mit11 (e-PCR), detects polymorphism
- UniSTS:116418

D14Mit108 (e-PCR), detects polymorphism
- UniSTS:127210

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase gamma

Names: Protein-tyrosine phosphatase gamma precursor (R-PTP-gamma); R-PTP-gamma

NP_001334522.1

EC 3.1.3.48

NP_033007.2

EC 3.1.3.48

XP_006518019.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347593.1 → NP_001334522.1 receptor-type tyrosine-protein phosphatase gamma isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is much shorter than isoform 1.

Source sequence(s)

AC154682, AK144283, CF724833

Consensus CDS

CCDS84092.1

UniProtKB/TrEMBL

Q3UND4
NM_008981.3 → NP_033007.2 receptor-type tyrosine-protein phosphatase gamma isoform 1 precursor

See identical proteins and their annotated locations for NP_033007.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC154682, AK134814, BC079595, L09562

Consensus CDS

CCDS26816.1

UniProtKB/Swiss-Prot

Q05909

UniProtKB/TrEMBL

A0A991ELE1

Related

ENSMUSP00000159543.1, ENSMUST00000248537.1

Conserved Domains (5) summary

PLN02179
Location:17 → 272

PLN02179; carbonic anhydrase

smart00194
Location:844 → 1115

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:873 → 1115

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:348 → 438

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd03122
Location:67 → 319

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

10227722..10916341 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006517956.5 → XP_006518019.1 receptor-type tyrosine-protein phosphatase gamma isoform X1

UniProtKB/Swiss-Prot

Q05909

Conserved Domains (5) summary

PRK12495
Location:613 → 689

PRK12495; hypothetical protein; Provisional

cd00063
Location:348 → 438

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd03122
Location:67 → 319

alpha_CARP_receptor_like; Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon ...

cd17667
Location:816 → 1089

R-PTPc-G-1; catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1

cd17670
Location:1173 → 1377

R-PTP-G-2; PTP-like domain of receptor-type tyrosine-protein phosphatase G, repeat 2