Rnase9 ribonuclease, RNase A family, 9 (non-active) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnase9provided by MGI
Official Full Name: ribonuclease, RNase A family, 9 (non-active)provided by MGI
Primary source: MGI:MGI:3057273
See related: Ensembl:ENSMUSG00000052382 AllianceGenome:MGI:3057273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ESRL; Rak1
Summary: Predicted to enable nucleic acid binding activity. Acts upstream of or within positive regulation of flagellated sperm motility involved in capacitation. Predicted to be located in extracellular region. Is expressed in ileum and jejunum. Orthologous to human RNASE9 (ribonuclease A family member 9 (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward genital fat pad adult (RPKM 174.4) See more
Orthologs: human all
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Genomic context

Location:: 14 C1; 14 26.35 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (51275916..51279360, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (51038459..51041903, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNASE9 is dispensable for fertility, but the absence of RNASE9 during epididymal transit results in impaired sperm maturation.
Title: Impaired sperm maturation in RNASE9 knockout mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables RNA nuclease activity	IKR Inferred from Key Residues more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of flagellated sperm motility involved in capacitation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inactive ribonuclease-like protein 9

Names: epididymal RNase; ribonuclease A family, member 9; ribonuclease A k1; ribonuclease-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183032.2 → NP_898853.2 inactive ribonuclease-like protein 9 precursor

See identical proteins and their annotated locations for NP_898853.2

Status: VALIDATED

Source sequence(s)

AY303816

Consensus CDS

CCDS36909.1

UniProtKB/Swiss-Prot

P60154

UniProtKB/TrEMBL

Q3KNL9, Q5QJV3

Related

ENSMUSP00000066637.4, ENSMUST00000064214.4

Conserved Domains (1) summary

cd00163
Location:57 → 178

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

51275916..51279360 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519142.4 → XP_006519205.1 inactive ribonuclease-like protein 9 isoform X1

See identical proteins and their annotated locations for XP_006519205.1

UniProtKB/Swiss-Prot

P60154

UniProtKB/TrEMBL

Q3KNL9, Q5QJV3

Conserved Domains (1) summary

cd00163
Location:57 → 178

RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...