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    Glis2 GLIS family zinc finger 2 [ Mus musculus (house mouse) ]

    Gene ID: 83396, updated on 9-Dec-2024

    Summary

    Official Symbol
    Glis2provided by MGI
    Official Full Name
    GLIS family zinc finger 2provided by MGI
    Primary source
    MGI:MGI:1932535
    See related
    Ensembl:ENSMUSG00000014303 AllianceGenome:MGI:1932535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkl; Gli5; Klf16
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of smoothened signaling pathway and regulation of DNA-templated transcription. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; positive regulation of protein localization to nucleus; and regulation of transcription by RNA polymerase II. Located in non-motile cilium and nuclear speck. Is expressed in several structures, including early conceptus; gut; nervous system; oocyte; and retina layer. Used to study nephronophthisis 7. Human ortholog(s) of this gene implicated in nephronophthisis 7. Orthologous to human GLIS2 (GLIS family zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 54.7), ovary adult (RPKM 24.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Glis2 in Genome Data Viewer
    Location:
    16 A1; 16 2.45 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4412217..4443076)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4594320..4625141)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene transcription factor AP4 Neighboring gene STARR-seq mESC enhancer starr_39936 Neighboring gene RIKEN cDNA D330022H12 gene Neighboring gene presequence translocase-asssociated motor 16 Neighboring gene STARR-seq mESC enhancer starr_39940 Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene STARR-positive B cell enhancer ABC_E10885 Neighboring gene STARR-seq mESC enhancer starr_39941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4683706-4683859 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene STARR-seq mESC enhancer starr_39942

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC36775

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation involved in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein localization to nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein GLIS2
    Names
    GLI-Kruppel family member GLI5
    GLI-similar 2
    Kruppel-like factor 16 (neuronal)
    neuronal Krueppel-like protein
    zinc finger protein GLI5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031184.3NP_112461.2  zinc finger protein GLIS2

      See identical proteins and their annotated locations for NP_112461.2

      Status: VALIDATED

      Source sequence(s)
      AC087899, CF727873, CN703218, CX563691
      Consensus CDS
      CCDS27920.1
      UniProtKB/Swiss-Prot
      Q8R4X9, Q8VDL9, Q99MY6, Q99P73
      Related
      ENSMUSP00000014447.7, ENSMUST00000014447.13
      Conserved Domains (2) summary
      COG5048
      Location:233327
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4412217..4443076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246050.3XP_011244352.1  zinc finger protein GLIS2 isoform X8

      Conserved Domains (3) summary
      COG5048
      Location:214258
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175192
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225246
      zf-H2C2_2; Zinc-finger double domain
    2. XM_011246048.4XP_011244350.1  zinc finger protein GLIS2 isoform X6

      Conserved Domains (3) summary
      COG5048
      Location:214270
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175192
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225246
      zf-H2C2_2; Zinc-finger double domain
    3. XM_011246049.3XP_011244351.1  zinc finger protein GLIS2 isoform X7

      Conserved Domains (3) summary
      COG5048
      Location:214274
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175192
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225246
      zf-H2C2_2; Zinc-finger double domain
    4. XM_036160187.1XP_036016080.1  zinc finger protein GLIS2 isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:241301
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:202219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:252273
      zf-H2C2_2; Zinc-finger double domain
    5. XM_036160188.1XP_036016081.1  zinc finger protein GLIS2 isoform X5

      Conserved Domains (3) summary
      COG5048
      Location:241285
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:202219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:252273
      zf-H2C2_2; Zinc-finger double domain
    6. XM_036160185.1XP_036016078.1  zinc finger protein GLIS2 isoform X1

      Conserved Domains (2) summary
      COG5048
      Location:260354
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240256
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. XM_036160186.1XP_036016079.1  zinc finger protein GLIS2 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:241297
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:202219
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:252273
      zf-H2C2_2; Zinc-finger double domain
    8. XM_006522768.5XP_006522831.1  zinc finger protein GLIS2 isoform X2

      See identical proteins and their annotated locations for XP_006522831.1

      UniProtKB/Swiss-Prot
      Q8R4X9, Q8VDL9, Q99MY6, Q99P73
      Conserved Domains (2) summary
      COG5048
      Location:233327
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213229
      ZF_C2H2; C2H2 Zn finger [structural motif]