Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Vasn vasorin [ Mus musculus (house mouse) ]

    Gene ID: 246154, updated on 27-Nov-2024

    Summary

    Official Symbol
    Vasnprovided by MGI
    Official Full Name
    vasorinprovided by MGI
    Primary source
    MGI:MGI:2177651
    See related
    Ensembl:ENSMUSG00000039646 AllianceGenome:MGI:2177651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atia; Slitl2; 2610528G05Rik
    Summary
    Predicted to enable transforming growth factor beta binding activity. Acts upstream of or within cellular response to hypoxia and cellular response to redox state. Located in mitochondrion and plasma membrane. Is expressed in several structures, including cardiovascular system; cranium; embryo mesenchyme; genitourinary system; and gut. Orthologous to human VASN (vasorin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 39.5), lung adult (RPKM 36.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Vasn in Genome Data Viewer
    Location:
    16 A1; 16 2.46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4457809..4469030)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4639945..4651166)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D330022H12 gene Neighboring gene GLIS family zinc finger 2 Neighboring gene presequence translocase-asssociated motor 16 Neighboring gene STARR-seq mESC enhancer starr_39940 Neighboring gene coronin 7 Neighboring gene STARR-positive B cell enhancer ABC_E10885 Neighboring gene STARR-seq mESC enhancer starr_39941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4683706-4683859 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene STARR-seq mESC enhancer starr_39942 Neighboring gene NmrA-like family domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transforming growth factor beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vasorin
    Names
    Slit-like 2
    protein slit-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139307.3NP_647468.2  vasorin precursor

      See identical proteins and their annotated locations for NP_647468.2

      Status: VALIDATED

      Source sequence(s)
      AI448688, AK132325, BF657819
      Consensus CDS
      CCDS27921.1
      UniProtKB/Swiss-Prot
      Q8BJJ0, Q8R2G5, Q9CZT5
      Related
      ENSMUSP00000045162.4, ENSMUST00000038770.4
      Conserved Domains (8) summary
      smart00013
      Location:2455
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:299350
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:76273
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:3557
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00008
      Location:410441
      EGF; EGF-like domain
      pfam00041
      Location:468537
      fn3; Fibronectin type III domain
      pfam12799
      Location:77118
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:102161
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4457809..4469030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)