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    Tfap4 transcription factor AP4 [ Mus musculus (house mouse) ]

    Gene ID: 83383, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tfap4provided by MGI
    Official Full Name
    transcription factor AP4provided by MGI
    Primary source
    MGI:MGI:103239
    See related
    Ensembl:ENSMUSG00000005718 AllianceGenome:MGI:103239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AP-4; Tcfap4; bHLHc41; D930048N17Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human TFAP4 (transcription factor AP-4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.3), CNS E11.5 (RPKM 2.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tfap4 in Genome Data Viewer
    Location:
    16 A1; 16 2.45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4362525..4378625, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4544661..4560762, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 9 Neighboring gene STARR-seq mESC enhancer starr_39924 Neighboring gene tubulin cofactor a pseudogene Neighboring gene sarcalumenin Neighboring gene STARR-positive B cell enhancer mm9_chr16:4541749-4542050 Neighboring gene STARR-seq mESC enhancer starr_39936 Neighboring gene RIKEN cDNA D330022H12 gene Neighboring gene GLIS family zinc finger 2 Neighboring gene presequence translocase-asssociated motor 16

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables E-box binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor AP-4
    Names
    transcription factor AP-4 (activating enhancer-binding protein 4)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419427.1NP_001406356.1  transcription factor AP-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157597
    2. NM_001419428.1NP_001406357.1  transcription factor AP-4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157597
    3. NM_001419429.1NP_001406358.1  transcription factor AP-4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157597
    4. NM_001419430.1NP_001406359.1  transcription factor AP-4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157597
    5. NM_001419431.1NP_001406360.1  transcription factor AP-4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157597
    6. NM_001419432.1NP_001406361.1  transcription factor AP-4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157597
    7. NM_001419433.1NP_001406362.1  transcription factor AP-4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157597
    8. NM_001419434.1NP_001406363.1  transcription factor AP-4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC157597
    9. NM_001419435.1NP_001406364.1  transcription factor AP-4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC157597
    10. NM_031182.3NP_112459.1  transcription factor AP-4 isoform 1

      See identical proteins and their annotated locations for NP_112459.1

      Status: VALIDATED

      Source sequence(s)
      AC157597
      Consensus CDS
      CCDS27919.1
      UniProtKB/TrEMBL
      Q8BWA4, Q9JIZ5
      Related
      ENSMUSP00000005862.8, ENSMUST00000005862.9
      Conserved Domains (1) summary
      pfam00010
      Location:49100
      HLH; Helix-loop-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4362525..4378625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522766.5XP_006522829.1  transcription factor AP-4 isoform X2

      See identical proteins and their annotated locations for XP_006522829.1

      UniProtKB/TrEMBL
      Q8BWA4
      Conserved Domains (1) summary
      cl00081
      Location:146
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    2. XM_006522765.4XP_006522828.1  transcription factor AP-4 isoform X2

      See identical proteins and their annotated locations for XP_006522828.1

      UniProtKB/TrEMBL
      Q8BWA4
      Conserved Domains (1) summary
      cl00081
      Location:146
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    3. XM_011246047.3XP_011244349.1  transcription factor AP-4 isoform X2

      See identical proteins and their annotated locations for XP_011244349.1

      UniProtKB/TrEMBL
      Q8BWA4
      Conserved Domains (1) summary
      cl00081
      Location:146
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    4. XM_030249340.1XP_030105200.1  transcription factor AP-4 isoform X2

      UniProtKB/TrEMBL
      Q8BWA4
      Conserved Domains (1) summary
      cl00081
      Location:146
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    5. XM_006522763.5XP_006522826.1  transcription factor AP-4 isoform X2

      See identical proteins and their annotated locations for XP_006522826.1

      UniProtKB/TrEMBL
      Q8BWA4
      Conserved Domains (1) summary
      cl00081
      Location:146
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    6. XM_017317166.3XP_017172655.1  transcription factor AP-4 isoform X1

      UniProtKB/TrEMBL
      Q8BWA4
      Conserved Domains (1) summary
      cd11419
      Location:2686
      bHLHzip_TFAP4; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins