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    Nmral1 NmrA-like family domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 67824, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nmral1provided by MGI
    Official Full Name
    NmrA-like family domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915074
    See related
    Ensembl:ENSMUSG00000063445 AllianceGenome:MGI:1915074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110025F24Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; genitourinary system; gut; and lung. Orthologous to human NMRAL1 (NmrA like redox sensor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 36.3), CNS E14 (RPKM 19.9) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nmral1 in Genome Data Viewer
    Location:
    16 A1; 16 2.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4529181..4537220, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4711317..4719356, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene STARR-positive B cell enhancer ABC_E10885 Neighboring gene STARR-seq mESC enhancer starr_39941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4683706-4683859 Neighboring gene STARR-seq mESC enhancer starr_39942 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4726231-4726340 Neighboring gene heme oxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_39943 Neighboring gene cell death inducing Trp53 target 1 Neighboring gene STARR-positive B cell enhancer ABC_E7425 Neighboring gene STARR-seq mESC enhancer starr_39945 Neighboring gene RIKEN cDNA 4930562C15 gene Neighboring gene predicted gene, 36513

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nmrA-like family domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290761.1NP_001277690.1  nmrA-like family domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter compared to isoform 1.
      Source sequence(s)
      AK146521, BC030039, BX527978
      Consensus CDS
      CCDS70678.1
      UniProtKB/TrEMBL
      D3YU12
      Related
      ENSMUSP00000112754.2, ENSMUST00000120056.8
      Conserved Domains (2) summary
      cd05251
      Location:7238
      NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
      COG0702
      Location:5206
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
    2. NM_001290762.1NP_001277691.1  nmrA-like family domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001277691.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA166262, AK012340, AK146521, BC030039, BX527978
      Consensus CDS
      CCDS70679.1
      UniProtKB/TrEMBL
      G5E8S7
      Related
      ENSMUSP00000111517.4, ENSMUST00000115851.10
      Conserved Domains (2) summary
      cd05251
      Location:7241
      NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
      COG0702
      Location:5206
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
    3. NM_001290763.1NP_001277692.1  nmrA-like family domain-containing protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001277692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK078389, BX527978
      Consensus CDS
      CCDS70680.1
      UniProtKB/Swiss-Prot
      Q8K2T1
      Related
      ENSMUSP00000074500.8, ENSMUST00000074970.8
      Conserved Domains (2) summary
      cd05251
      Location:7238
      NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
      COG0702
      Location:5206
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]
    4. NM_026393.2NP_080669.1  nmrA-like family domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC030039, BX527978
      Consensus CDS
      CCDS27923.1
      UniProtKB/Swiss-Prot
      Q8BVF0, Q8K2T1, Q9CZP2
      Related
      ENSMUSP00000078132.8, ENSMUST00000079130.14
      Conserved Domains (2) summary
      cd05251
      Location:7248
      NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
      COG0702
      Location:5216
      YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4529181..4537220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)