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    Zfpl1 zinc finger like protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 81909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfpl1provided by MGI
    Official Full Name
    zinc finger like protein 1provided by MGI
    Primary source
    MGI:MGI:1891017
    See related
    Ensembl:ENSMUSG00000024792 AllianceGenome:MGI:1891017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut gland; and retina. Orthologous to human ZFPL1 (zinc finger protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 42.5), adrenal adult (RPKM 37.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfpl1 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6130792..6134961, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6080757..6084975, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45418 Neighboring gene zinc finger, HIT domain containing 2 Neighboring gene transmembrane 7 superfamily member 2 Neighboring gene VPS51 GARP complex subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6077181-6077364 Neighboring gene transmembrane protein 262 Neighboring gene STARR-positive B cell enhancer ABC_E3238 Neighboring gene STARR-positive B cell enhancer ABC_E4262 Neighboring gene cell division cycle associated 5 Neighboring gene predicted gene 550

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1. Höppener JW, et al. Genomics, 1998 Jun 1. PMID 9653652
    2. ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. Chiu CF, et al. EMBO J, 2008 Apr 9. PMID 18323775, Free PMC Article
    3. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Wang F, et al. Sci Adv, 2022 Jan 7. PMID 34995116, Free PMC Article
    4. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
    5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 1500015B20Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356994.2 → NP_001343923.1  zinc finger protein-like 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131692
      Consensus CDS
      CCDS29492.1
      UniProtKB/Swiss-Prot
      Q9DB43
      UniProtKB/TrEMBL
      A0A494B9Y9
      Related
      ENSMUSP00000125176.2, ENSMUST00000160977.8
      Conserved Domains (1) summary
      cd16487
      Location:50 → 104
      mRING-H2-C3DHC3_ZFPL1; Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins

    2. NM_001424811.1 → NP_001411740.1  zinc finger protein-like 1

      Status: VALIDATED

      Source sequence(s)
      AC131692
      UniProtKB/Swiss-Prot
      Q9DB43
      UniProtKB/TrEMBL
      A0A494B9Y9

    3. NM_001424812.1 → NP_001411741.1  zinc finger protein-like 1

      Status: VALIDATED

      Source sequence(s)
      AC131692
      UniProtKB/Swiss-Prot
      Q9DB43
      UniProtKB/TrEMBL
      A0A494B9Y9

    4. NM_024231.4 → NP_077193.1  zinc finger protein-like 1

      See identical proteins and their annotated locations for NP_077193.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131692
      Consensus CDS
      CCDS29492.1
      UniProtKB/Swiss-Prot
      Q9DB43
      UniProtKB/TrEMBL
      A0A494B9Y9
      Related
      ENSMUSP00000025707.3, ENSMUST00000025707.9
      Conserved Domains (1) summary
      cd16487
      Location:50 → 104
      mRING-H2-C3DHC3_ZFPL1; Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6130792..6134961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB43.1 GenPept UniProtKB/Swiss-Prot:Q9DB43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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