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    Tent5b terminal nucleotidyltransferase 5B [ Mus musculus (house mouse) ]

    Gene ID: 100342, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tent5bprovided by MGI
    Official Full Name
    terminal nucleotidyltransferase 5Bprovided by MGI
    Primary source
    MGI:MGI:2140500
    See related
    Ensembl:ENSMUSG00000046694 AllianceGenome:MGI:2140500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam46b; 4732473B16Rik
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of cell population proliferation; and positive regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Orthologous to human TENT5B (terminal nucleotidyltransferase 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 17.7), stomach adult (RPKM 15.3) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Tent5b in Genome Data Viewer
    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133207444..133215251)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133480133..133487940)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700091J24 gene Neighboring gene STARR-seq mESC enhancer starr_11631 Neighboring gene predicted gene, 42322 Neighboring gene STARR-positive B cell enhancer ABC_E7996 Neighboring gene STARR-positive B cell enhancer ABC_E9598 Neighboring gene predicted gene 13257 Neighboring gene STARR-positive B cell enhancer ABC_E4676 Neighboring gene TMF1-regulated nuclear protein 1 Neighboring gene predicted gene, 42323 Neighboring gene keratinocyte differentiation factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    terminal nucleotidyltransferase 5B
    Names
    family with sequence similarity 46, member B
    non-canonical poly(A) polymerase FAM46B
    protein FAM46B
    putative nucleotidyltransferase FAM46B
    NP_780516.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175307.6NP_780516.1  terminal nucleotidyltransferase 5B

      See identical proteins and their annotated locations for NP_780516.1

      Status: VALIDATED

      Source sequence(s)
      AL627228
      Consensus CDS
      CCDS18748.1
      UniProtKB/Swiss-Prot
      Q3TSC3, Q8C152, Q8CI10
      Related
      ENSMUSP00000056015.7, ENSMUST00000051676.7
      Conserved Domains (1) summary
      pfam07984
      Location:52371
      NTP_transf_7; Nucleotidyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      133207444..133215251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)