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    Zar1 zygote arrest 1 [ Mus musculus (house mouse) ]

    Gene ID: 317755, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zar1provided by MGI
    Official Full Name
    zygote arrest 1provided by MGI
    Primary source
    MGI:MGI:2180337
    See related
    Ensembl:ENSMUSG00000063935 AllianceGenome:MGI:2180337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables RNA sequestering activity; mRNA 3'-UTR binding activity; and molecular condensate scaffold activity. Involved in non-membrane-bounded organelle assembly; oocyte maturation; and post-transcriptional regulation of gene expression. Is active in cytoplasm and intracellular non-membrane-bounded organelle. Is expressed in early conceptus; ovary; and rib. Orthologous to human ZAR1 (zygote arrest 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward ovary adult (RPKM 33.1) See more
    Orthologs
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    Genomic context

    See Zar1 in Genome Data Viewer
    Location:
    5 C3.2; 5 38.44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72734457..72738427, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72577113..72581361, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene nuclear transcription factor, X-box binding-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:72950846-72951147 Neighboring gene predicted gene, 34144 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), pseudogene Neighboring gene cyclic nucleotide gated channel alpha 1 Neighboring gene predicted gene 5297

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Clone Names

    • MGC123986, MGC123987

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA sequestering activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular condensate scaffold activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in membraneless organelle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oocyte maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membraneless organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zygote arrest protein 1
    Names
    oocyte-specific maternal effect factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424683.1NP_001411612.1  zygote arrest protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122733
    2. NM_174877.3NP_777366.1  zygote arrest protein 1 isoform 1

      See identical proteins and their annotated locations for NP_777366.1

      Status: VALIDATED

      Source sequence(s)
      BC099399, DV647930
      Consensus CDS
      CCDS19331.1
      UniProtKB/Swiss-Prot
      Q4FZK8, Q80SU3
      Related
      ENSMUSP00000073221.3, ENSMUST00000073528.4
      Conserved Domains (1) summary
      pfam13695
      Location:262347
      zf-3CxxC; Zinc-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      72734457..72738427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)