Tmprss11b transmembrane protease, serine 11B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmprss11bprovided by MGI
Official Full Name: transmembrane protease, serine 11Bprovided by MGI
Primary source: MGI:MGI:2442893
See related: Ensembl:ENSMUSG00000035861 AllianceGenome:MGI:2442893
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmprss11bnl; 9930019B18Rik
Summary: Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Is expressed in ductus deferens; prostate gland; and testis. Orthologous to human TMPRSS11B (transmembrane serine protease 11B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (86806326..86824221, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86659522..86676298, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane protease serine 11B-like protein

Names: airway trypsin-like protease 5; transmembrane protease, serine 11b N terminal like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177024.5 → NP_795998.2 transmembrane protease serine 11B-like protein

See identical proteins and their annotated locations for NP_795998.2

Status: VALIDATED

Source sequence(s)

AC103930

Consensus CDS

CCDS39126.1

UniProtKB/Swiss-Prot

Q14C59, Q8BZ13, Q8BZ30

Related

ENSMUSP00000042406.7, ENSMUST00000038448.7

Conserved Domains (3) summary

smart00020
Location:184 → 410

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:185 → 413

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:46 → 140

SEA; SEA domain