Trip6 thyroid hormone receptor interactor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trip6provided by MGI
Official Full Name: thyroid hormone receptor interactor 6provided by MGI
Primary source: MGI:MGI:1343458
See related: Ensembl:ENSMUSG00000023348 AllianceGenome:MGI:1343458
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable interleukin-1 receptor binding activity and kinase binding activity. Involved in chordate embryonic development. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and nucleus. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and skin. Orthologous to human TRIP6 (thyroid hormone receptor interactor 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 46.7), adrenal adult (RPKM 40.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.34 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137308160..137312469, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137309898..137314480, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIP6 promotes neural stem cell maintenance through YAP-mediated Sonic Hedgehog activation.
Title: TRIP6 promotes neural stem cell maintenance through YAP-mediated Sonic Hedgehog activation.
TRIP6 disrupts tight junctions to promote metastasis and drug resistance and is a therapeutic target in colorectal cancer.
Title: TRIP6 disrupts tight junctions to promote metastasis and drug resistance and is a therapeutic target in colorectal cancer.
TRIP6 functions in brain ciliogenesis.
Title: TRIP6 functions in brain ciliogenesis.
The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation.
Title: The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation.
PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.
Title: PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.
Data report that nTRIP6 acts as a co-repressor for MEF2C in myoblasts. nTRIP6 interacts via its N-terminal pre-LIM region with MEF2C in the nucleus of myoblasts, is recruited together with MEF2C to the regulatory regions of MEF2C target genes and represses their expression.
Title: The LIM domain protein nTRIP6 acts as a co-repressor for the transcription factor MEF2C in myoblasts.
Our data suggest that TRIP6 regulates neural stem cell maintenance and it may be a new marker for neural stem cells.
Title: TRIP6 regulates neural stem cell maintenance in the postnatal mammalian subventricular zone.
TRIP6 is an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity. (Review)
Title: TRIP6: an adaptor protein that regulates cell motility, antiapoptotic signaling and transcriptional activity.
Data show that OIP-1 (Trip6) is an important physiologic regulator of osteoclast development and may have therapeutic utility for bone diseases with high bone turnover.
Title: Osteoclast inhibitory peptide-1 binding to the Fc gammaRIIB inhibits osteoclast differentiation.
TRIP6 is a critical downstream regulator of c-Src signaling and its phosphorylation is permissive for its presence in the sealing zone where it plays a positive role in osteoclast bone resorptive capacity
Title: c-Src-mediated phosphorylation of thyroid hormone receptor-interacting protein 6 (TRIP6) promotes osteoclast sealing zone formation.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-1 receptor binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in chordate embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thyroid receptor-interacting protein 6

Names: TR-interacting protein 6; TRIP-6; ZRP-1; zyxin-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417589.1 → NP_001404518.1 thyroid receptor-interacting protein 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC150682
NM_001417590.1 → NP_001404519.1 thyroid receptor-interacting protein 6 isoform 3

Status: VALIDATED

Source sequence(s)

AC150682
NM_011639.4 → NP_035769.1 thyroid receptor-interacting protein 6 isoform 1

See identical proteins and their annotated locations for NP_035769.1

Status: VALIDATED

Source sequence(s)

AC150682

Consensus CDS

CCDS19765.1

UniProtKB/Swiss-Prot

Q3TX74, Q9Z1Y4

UniProtKB/TrEMBL

B2RS30, Q3TMB5

Related

ENSMUSP00000024119.10, ENSMUST00000024119.11

Conserved Domains (3) summary

cd09350
Location:283 → 336

LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)

cd09357
Location:403 → 465

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cl02475
Location:343 → 402

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers