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    Tafa1 TAFA chemokine like family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 320265, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tafa1provided by MGI
    Official Full Name
    TAFA chemokine like family member 1provided by MGI
    Primary source
    MGI:MGI:2443695
    See related
    Ensembl:ENSMUSG00000059187 AllianceGenome:MGI:2443695
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tafa-1; Fam19a1; C630007B19Rik; FAM19A1 TAFA-1
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in cortex adult (RPKM 3.1), CNS E18 (RPKM 2.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tafa1 in Genome Data Viewer
    Location:
    6 D3; 6 44.67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (96090135..96634169)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (96113154..96657204)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060L22 gene Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_16753 Neighboring gene STARR-seq mESC enhancer starr_16754 Neighboring gene calmodulin 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16755 Neighboring gene nucleoporin 50 like Neighboring gene STARR-seq mESC enhancer starr_16758 Neighboring gene STARR-seq mESC enhancer starr_16759 Neighboring gene STARR-seq mESC enhancer starr_16760 Neighboring gene predicted gene, 22971 Neighboring gene STARR-seq mESC enhancer starr_16762 Neighboring gene predicted gene, 26011 Neighboring gene STARR-seq mESC enhancer starr_16763 Neighboring gene STARR-seq mESC enhancer starr_16764 Neighboring gene STARR-seq mESC enhancer starr_16765 Neighboring gene STARR-seq mESC enhancer starr_16766 Neighboring gene TAFA chemokine like family member 4 Neighboring gene STARR-seq mESC enhancer starr_16767 Neighboring gene STARR-seq mESC enhancer starr_16770 Neighboring gene STARR-seq mESC enhancer starr_16771 Neighboring gene STARR-seq mESC enhancer starr_16773 Neighboring gene STARR-seq mESC enhancer starr_16775 Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1. Yong HJ, et al. Cells, 2021 Jul 23. PMID 34440636, Free PMC Article
    2. FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors. Lei X, et al. FASEB J, 2019 Dec. PMID 31689372, Free PMC Article
    3. Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism. Khalaj AJ, et al. J Cell Biol, 2020 Sep 7. PMID 32706374, Free PMC Article
    4. FAM19A1 is a new ligand for GPR1 that modulates neural stem-cell proliferation and differentiation. Zheng C, et al. FASEB J, 2018 May 25. PMID 29799787
    5. The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition. Yong HJ, et al. Sci Rep, 2020 Mar 2. PMID 32123192, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1.
      Title: Alterations in Dendritic Spine Maturation and Neurite Development Mediated by FAM19A1.
    2. Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.
      Title: Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.
    3. In male mice, FAM19A1 deficiency alters food intake patterns during the light and dark cycle. Fam19a1 KO mice are hyperactive, and locomotor hyperactivity is more pronounced in female KO mice.
      Title: FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuroblast differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuroblast differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neuroblast proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemokine-like protein TAFA-1
    Names
    family with sequence similarity 19, member A1
    protein FAM19A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_182808.3 → NP_877960.1  chemokine-like protein TAFA-1 precursor

      See identical proteins and their annotated locations for NP_877960.1

      Status: VALIDATED

      Source sequence(s)
      AC158674, AK049880, AK050001, AY325120
      Consensus CDS
      CCDS39574.1
      UniProtKB/Swiss-Prot
      A2RSN6, Q7TPG8
      Related
      ENSMUSP00000113152.2, ENSMUST00000122120.8
      Conserved Domains (1) summary
      pfam12020
      Location:41 → 129
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      96090135..96634169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321638.3 → XP_017177127.1  chemokine-like protein TAFA-1 isoform X1

      Conserved Domains (1) summary
      pfam12020
      Location:65 → 153
      TAFA; TAFA family

    2. XM_036166225.1 → XP_036022118.1  chemokine-like protein TAFA-1 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:40 → 128
      TAFA; TAFA family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPG8.1 GenPept UniProtKB/Swiss-Prot:Q7TPG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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